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The measurement of parameters that describe kinetic processes is important in the study of molecular interactions. It enables a deeper understanding of the physical mechanisms underlying how different biological entities interact with each…

Quantum Physics · Physics 2022-05-16 K. T. Mpofu , C. Lee , G. E. M. Maguire , H. G. Kruger , M. S. Tame

Analyzing the kinetics of biological processes plays a significant role in understanding fundamental cellular functions. Many physics-based technologies used to study such processes are limited by the shot noise inherent to the coherent…

Quantum Physics · Physics 2025-04-16 Mrunal Kamble , Evan Humberd , Tian Li , Girish S. Agarwal

We demonstrated a biosensing approach which, for the first time, combines the high-sensitivity of whispering gallery modes (WGM) with a metallic nanoparticle based assay. We provided a computational model based on generalized Mie theory to…

The work done in this paper is an extension of the work done by Mpofu et al in [1]. The motivation for this paper is to show the potential of quantum bio-sensing techniques in applications to complex viruses like the human immunodeficiency…

Quantum Physics · Physics 2022-07-19 K. T. Mpofu , C. Lee , G. E. M. Maguire , H. G. Kruger , M. S. Tame

Reducing the noise below the shot-noise limit in sensing devices is one of the key promises of quantum technologies. Here, we study quantum plasmonic sensing based on an attenuated total reflection configuration with single photons as…

Optical interferometry is amongst the most sensitive techniques for precision measurement. By increasing the light intensity a more precise measurement can usually be made. However, in some applications the sample is light sensitive. By…

The clinical need for ultra-sensitive molecular analysis has motivated the development of several endpoint assay technologies capable of single molecule readout. These endpoint assays are now primarily limited by the affinity and…

Biological Physics · Physics 2019-05-22 Derin Sevenler , Jacob Trueb , M. Selim Ünlü

The extraordinary sensitivity of plasmonic sensors is well known in the optics and photonics community. These sensors exploit simultaneously the enhancement and the localization of electromagnetic fields close to the interface between a…

We have developed a biosensor based on BSA with the help of metal ions binding mechanism to detect and remove inorganic As(III), Cu(II), Pb(II) from water like fishing by hooking system.

Biological Physics · Physics 2014-04-03 Hari Shankar Biswasa , Kausik Gupta , Jagannath Datta , Uday Chand Ghosh , Nihar Ranjan Ray

Bell state analyzer (BSA) is one of the most crucial apparatus in photonic quantum information processing. While linear optics provide a practical way to implement BSA, it provides unavoidable errors when inputs are not ideal single-photon…

A bio-colloidal drying droplet can be used as a pre-diagnostic technique. However, a successful clinical setting requires a fundamental understanding of the final morphology and the way it is related to the initial state of the constituents…

Soft Condensed Matter · Physics 2021-05-14 Anusuya Pal , Amalesh Gope , Germano S. Iannacchione

Quantum probing is the art of exploiting simple quantum systems interacting with a complex environment to extract precise information about some environmental parameters, e.g. the temperature of the environment or its spectral density. Here…

Quantum Physics · Physics 2020-08-26 Dario Tamascelli , Claudia Benedetti , Heinz-Peter Breuer , Matteo G. A. Paris

Atomic-level simulations are widely used to study biomolecules and their dynamics. A common goal in such studies is to compare simulations of a molecular system under several conditions -- for example, with various mutations or bound…

Biomolecules · Quantitative Biology 2025-01-07 Martin Vögele , Neil J. Thomson , Sang T. Truong , Jasper McAvity , Ulrich Zachariae , Ron O. Dror

Accurate measurements of kinetic rate constants for interacting biomolecules is crucial for understanding the mechanisms underlying intracellular signalling pathways. The magnitude of binding rates plays a very important molecular…

Quantitative Methods · Quantitative Biology 2013-12-02 Hugo B. Brandao , Hussain Sangji , Elvis Pandzic , Susanne Bechstedt , Gary J. Brouhard , Paul W. Wiseman

Quantum photonics has demonstrated its potential for enhanced sensing. Current sources of quantum light states tailored to measuring, allow to monitor phenomena evolving on time scales of the order of the second. These are characteristic of…

Sensing of parameters is an important aspect in all disciplines, with applications ranging from fundamental science to medicine. Quantum sensing and metrology is an emerging field that lies at the cross-roads of quantum physics, quantum…

Quantum Physics · Physics 2025-12-30 Keshav Das Agarwal , Sayan Mondal , Ayan Sahoo , Debraj Rakshit , Aditi Sen De , Ujjwal Sen

Naturally occurring paramagnetic species (PS), such as free radicals and paramagnetic metalloproteins, play an essential role in a multitude of critical physiological processes including metabolism, cell signaling and immune response. These…

Quantum sensing harnesses the unique properties of quantum systems to enable precision measurements of physical quantities such as time, magnetic and electric fields, acceleration, and gravitational gradients well beyond the limits of…

Quantum Physics · Physics 2025-07-23 Ivana Nikoloska , Ruud Van Sloun , Osvaldo Simeone

Hybrid quantum mechanical-molecular mechanical (QM/MM) simulations are widely used in enzyme simulation. Over ten convergence studies of QM/MM methods have revealed over the past several years that key energetic and structural properties…

Chemical Physics · Physics 2017-01-11 Maria Karelina , Heather J. Kulik

Quantum sensing utilizes quantum systems as sensors to capture weak signal, and provides new opportunities in nowadays science and technology. The strongest adversary in quantum sensing is decoherence due to the coupling between the sensor…

Quantum Physics · Physics 2020-07-15 Yijin Xie , Jianpei Geng , Huiyao Yu , Xing Rong , Ya Wang , Jiangfeng Du
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