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Mitochondria instance segmentation from electron microscopy (EM) images has seen notable progress since the introduction of deep learning methods. In this paper, we propose two advanced deep networks, named Res-UNet-R and Res-UNet-H, for 3D…

Computer Vision and Pattern Recognition · Computer Science 2022-05-10 Mingxing Li , Chang Chen , Xiaoyu Liu , Wei Huang , Yueyi Zhang , Zhiwei Xiong

Recent successes in deep learning have started to impact neuroscience. Of particular significance are claims that current segmentation algorithms achieve "super-human" accuracy in an area known as connectomics. However, as we will show,…

Computer Vision and Pattern Recognition · Computer Science 2020-01-20 Drew Linsley , Junkyung Kim , David Berson , Thomas Serre

Electron tomography offers important three-dimensional (3D) structural information which cannot be observed by two-dimensional imaging. By combining annular dark field scanning transmission electron microscopy (ADF-STEM) with aberration…

Materials Science · Physics 2023-06-29 Juhyeok Lee , Moosung Lee , YongKeun Park , Colin Ophus , Yongsoo Yang

The promise of extracting connectomes and performing useful analysis on large electron microscopy (EM) datasets has been an elusive dream for many years. Tracing in even the smallest portions of neuropil requires copious human annotation,…

Automatic detection and segmentation of objects in 2D and 3D microscopy data is important for countless biomedical applications. In the natural image domain, spatial embedding-based instance segmentation methods are known to yield…

Image and Video Processing · Electrical Eng. & Systems 2021-04-30 Manan Lalit , Pavel Tomancak , Florian Jug

To investigate the processing of speech in the brain, simple linear models are commonly used to establish a relationship between brain signals and speech features. However, these linear models are ill-equipped to model a highly dynamic and…

Signal Processing · Electrical Eng. & Systems 2024-09-24 Xiran Xu , Bo Wang , Yujie Yan , Haolin Zhu , Zechen Zhang , Xihong Wu , Jing Chen

Seeing is believing, however, the underlying mechanism of how human visual perceptions are intertwined with our cognitions is still a mystery. Thanks to the recent advances in both neuroscience and artificial intelligence, we have been able…

Image and Video Processing · Electrical Eng. & Systems 2023-08-17 Yu-Ting Lan , Kan Ren , Yansen Wang , Wei-Long Zheng , Dongsheng Li , Bao-Liang Lu , Lili Qiu

Surface-based analysis of the cerebral cortex is ubiquitous in human neuroimaging with MRI. It is crucial for cortical registration, parcellation, and thickness estimation. Traditionally, these analyses require high-resolution, isotropic…

Image and Video Processing · Electrical Eng. & Systems 2024-09-09 Karthik Gopinath , Douglas N. Greve , Colin Magdamo , Steve Arnold , Sudeshna Das , Oula Puonti , Juan Eugenio Iglesias

We present a computational imaging mode for large scale electron microscopy data, which retrieves a complex wave from noisy/sparse intensity recordings using a deep learning approach and subsequently reconstructs an image of the specimen…

Materials Science · Physics 2022-02-28 Thomas Friedrich , Chu-Ping Yu , Johan Verbeek , Timothy Pennycook , Sandra Van Aert

Artificial Neural Networks (ANNs) are a promising approach to the decoding problem of Quantum Error Correction (QEC), but have observed consistent difficulty when generalising performance to larger QEC codes. Recent scalability-focused…

Quantum Physics · Physics 2026-05-08 Spiro Gicev , Lloyd C. L. Hollenberg , Muhammad Usman

The tracing of neural pathways through large volumes of image data is an incredibly tedious and time-consuming process that significantly encumbers progress in neuroscience. We are exploring deep learning's potential to automate…

Computer Vision and Pattern Recognition · Computer Science 2018-09-05 Ishtar Nyawira , Kristi Bushman , Iris Qian , Annie Zhang

Brain science is an evolving research area inviting great enthusiasm with its potential for providing insights and thereby, preventing, and treating multiple neuronal disorders affecting millions of patients. Discovery of relationships,…

Neurons and Cognition · Quantitative Biology 2016-03-17 Bisakha Ray , Alexander V. Alekseyenko , Sisi Ma , Alexander Statnikov , Constantin Aliferis

We present a method for estimating intravoxel parameters from a DW-MRI based on deep learning techniques. We show that neural networks (DNNs) have the potential to extract information from diffusion-weighted signals to reconstruct cerebral…

Image and Video Processing · Electrical Eng. & Systems 2022-01-02 Hanna Ehrlich , Mariano Rivera

This short paper briefly presents our methodology details of automatic intracranial aneurysms segmentation from brain MR scans. We use ensembles of multiple models trained from different loss functions. Our method ranked first place in the…

Image and Video Processing · Electrical Eng. & Systems 2021-01-27 Jun Ma

One of the critical steps in improving accurate single neuron reconstruction from three-dimensional (3D) optical microscope images is the neuronal structure segmentation. However, they are always hard to segment due to the lack in quality.…

Image and Video Processing · Electrical Eng. & Systems 2021-01-25 Heng Wang , Yang Song , Chaoyi Zhang , Jianhui Yu , Siqi Liu , Hanchuan Peng , Weidong Cai

Semantic segmentation is a crucial task in biomedical image processing, which recent breakthroughs in deep learning have allowed to improve. However, deep learning methods in general are not yet widely used in practice since they require…

Computer Vision and Pattern Recognition · Computer Science 2019-07-12 Melanie Lubrano di Scandalea , Christian S. Perone , Mathieu Boudreau , Julien Cohen-Adad

Cryo-electron microscopy (cryo-EM) is an indispensable technique for determining the 3D structures of dynamic biomolecular complexes. While typically applied to image a single molecular species, cryo-EM has the potential for structure…

Computer Vision and Pattern Recognition · Computer Science 2026-03-23 Jeffrey Gu , Minkyu Jeon , Ambri Ma , Serena Yeung-Levy , Ellen D. Zhong

While functional magnetic resonance imaging (fMRI) offers valuable insights into brain activity, it is limited by high operational costs and significant infrastructural demands. In contrast, electroencephalography (EEG) provides…

Computer Vision and Pattern Recognition · Computer Science 2025-04-29 Kristofer Grover Roos , Atsushi Fukuda , Quan Huu Cap

Reconstructing multiple molecularly defined neurons from individual brains and across multiple brain regions can reveal organizational principles of the nervous system. However, high resolution imaging of the whole brain is a technically…

Computer Vision and Pattern Recognition · Computer Science 2019-03-19 James Gornet , Kannan Umadevi Venkataraju , Arun Narasimhan , Nicholas Turner , Kisuk Lee , H. Sebastian Seung , Pavel Osten , Uygar Sümbül

Human's perception of the visual world is shaped by the stereo processing of 3D information. Understanding how the brain perceives and processes 3D visual stimuli in the real world has been a longstanding endeavor in neuroscience. Towards…

Computer Vision and Pattern Recognition · Computer Science 2025-08-06 Zhanqiang Guo , Jiamin Wu , Yonghao Song , Jiahui Bu , Weijian Mai , Qihao Zheng , Wanli Ouyang , Chunfeng Song
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