Recent successes in deep learning have started to impact neuroscience. Of particular significance are claims that current segmentation algorithms achieve "super-human" accuracy in an area known as connectomics. However, as we will show, these algorithms do not effectively generalize beyond the particular source and brain tissues used for training -- severely limiting their usability by the broader neuroscience community. To fill this gap, we describe a novel connectomics challenge for source- and tissue-agnostic reconstruction of neurons (STAR), which favors broad generalization over fitting specific datasets. We first demonstrate that current state-of-the-art approaches to neuron segmentation perform poorly on the challenge. We further describe a novel convolutional recurrent neural network module that combines short-range horizontal connections within a processing stage and long-range top-down connections between stages. The resulting architecture establishes the state of the art on the STAR challenge and represents a significant step towards widely usable and fully-automated connectomics analysis.
@article{arxiv.1811.11356,
title = {Robust neural circuit reconstruction from serial electron microscopy with convolutional recurrent networks},
author = {Drew Linsley and Junkyung Kim and David Berson and Thomas Serre},
journal= {arXiv preprint arXiv:1811.11356},
year = {2020}
}