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Determining the 3D structures of biological molecules is a key problem for both biology and medicine. Electron Cryomicroscopy (Cryo-EM) is a promising technique for structure estimation which relies heavily on computational methods to…

Machine Learning · Statistics 2015-01-29 Ali Punjani , Marcus A. Brubaker

Half of wavefunction information is undetected by conventional transmission electron microscopy (CTEM) as only the intensity, and not the phase, of an image is recorded. Following successful applications of deep learning to optical hologram…

Image and Video Processing · Electrical Eng. & Systems 2020-01-31 Jeffrey M. Ede , Jonathan J. P. Peters , Jeremy Sloan , Richard Beanland

Planning of radiotherapy involves accurate segmentation of a large number of organs at risk, i.e. organs for which irradiation doses should be minimized to avoid important side effects of the therapy. We propose a deep learning method for…

Image and Video Processing · Electrical Eng. & Systems 2019-07-04 Pawel Mlynarski , Hervé Delingette , Hamza Alghamdi , Pierre-Yves Bondiau , Nicholas Ayache

Analysis and visualization of 3D microscopy images pose challenges due to anisotropic axial resolution, demanding volumetric super-resolution along the axial direction. While training a learning-based 3D super-resolution model seems to be a…

Image and Video Processing · Electrical Eng. & Systems 2024-08-19 Kyungryun Lee , Won-Ki Jeong

Structured illumination microscopy (SIM) is a pivotal technique for dynamic subcellular imaging in live cells. Conventional SIM reconstruction algorithms depend on accurately estimating the illumination pattern and can introduce artefacts…

One primary technical challenge in photoacoustic microscopy (PAM) is the necessary compromise between spatial resolution and imaging speed. In this study, we propose a novel application of deep learning principles to reconstruct…

Image and Video Processing · Electrical Eng. & Systems 2020-06-02 Anthony DiSpirito , Daiwei Li , Tri Vu , Maomao Chen , Dong Zhang , Jianwen Luo , Roarke Horstmeyer , Junjie Yao

Fetal cortical plate segmentation is essential in quantitative analysis of fetal brain maturation and cortical folding. Manual segmentation of the cortical plate, or manual refinement of automatic segmentations is tedious and…

Computer Vision and Pattern Recognition · Computer Science 2021-04-05 Haoran Dou , Davood Karimi , Caitlin K. Rollins , Cynthia M. Ortinau , Lana Vasung , Clemente Velasco-Annis , Abdelhakim Ouaalam , Xin Yang , Dong Ni , Ali Gholipour

Despite advances in deep learning, robustness under domain shift remains a major bottleneck in medical imaging settings. Findings on natural images suggest that deep neural models can show a strong textural bias when carrying out image…

Image and Video Processing · Electrical Eng. & Systems 2021-06-29 Seoin Chai , Daniel Rueckert , Ahmed E. Fetit

This study investigates the impact of self-supervised pretraining of 3D semantic segmentation models on a large-scale, domain-specific dataset. We introduce BRAINS-45K, a dataset of 44,756 brain MRI volumes from public sources, the largest…

Image and Video Processing · Electrical Eng. & Systems 2024-08-16 Asbjørn Munk , Jakob Ambsdorf , Sebastian Llambias , Mads Nielsen

Nowadays, modern electron microscopes deliver images at atomic scale. The precise atomic structure encodes information about material properties. Thus, an important ingredient in the image analysis is to locate the centers of the atoms…

Computer Vision and Pattern Recognition · Computer Science 2017-09-13 Benjamin Berkels , Benedikt Wirth

Modeling the 3D structures of cells and tissues is crucial in biology. Sequential cross-sectional images from electron microscopy provide high-resolution intracellular structure information. The segmentation of complex cell structures…

Quantitative Methods · Quantitative Biology 2025-02-14 Jin Kousaka , Atsuko H. Iwane , Yuichi Togashi

Brain magnetic resonance (MR) segmentation for hydrocephalus patients is considered as a challenging work. Encoding the variation of the brain anatomical structures from different individuals cannot be easily achieved. The task becomes even…

Image and Video Processing · Electrical Eng. & Systems 2020-01-14 Xuhua Ren , Jiayu Huo , Kai Xuan , Dongming Wei , Lichi Zhang , Qian Wang

Decoding the human brain has been a hallmark of neuroscientists and Artificial Intelligence researchers alike. Reconstruction of visual images from brain Electroencephalography (EEG) signals has garnered a lot of interest due to its…

Computer Vision and Pattern Recognition · Computer Science 2023-10-26 Prajwal Singh , Dwip Dalal , Gautam Vashishtha , Krishna Miyapuram , Shanmuganathan Raman

Network science has been extensively developed to characterize structural properties of complex systems, including brain networks inferred from neuroimaging data. As a result of the inference process, networks estimated from experimentally…

Neurons and Cognition · Quantitative Biology 2017-03-10 Catalina Obando , Fabrizio De Vico Fallani

Motivation: Cellular Electron CryoTomography (CECT) enables 3D visualization of cellular organization at near-native state and in sub-molecular resolution, making it a powerful tool for analyzing structures of macromolecular complexes and…

Quantitative Methods · Quantitative Biology 2017-04-14 Min Xu , Xiaoqi Chai , Hariank Muthakana , Xiaodan Liang , Ge Yang , Tzviya Zeev-Ben-Mordehai , Eric Xing

AI-based in silico methods have improved protein structure prediction but often struggle with large protein complexes (PCs) involving multiple interacting proteins due to missing 3D spatial cues. Experimental techniques like Cryo-EM are…

Region-based methods have proven necessary for improving segmentation accuracy of neuronal structures in electron microscopy (EM) images. Most region-based segmentation methods use a scoring function to determine region merging. Such…

Computer Vision and Pattern Recognition · Computer Science 2018-04-04 Ting Liu , Miaomiao Zhang , Mehran Javanmardi , Nisha Ramesh , Tolga Tasdizen

Precise segmentation of brain structures in magnetic resonance imaging (MRI) is essential for reliable neuroimaging analysis, yet voxel-wise deep models often yield anatomically inconsistent results that diverge from expert-defined…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Ahmed Rekik , R. Jarrett Rushmore , Sylvain Bouix , Linda Marrakchi-Kacem

Electroencephalography (EEG) is a non-invasive technique for recording brain activity, widely used in brain-computer interfaces, clinic, and healthcare. Traditional EEG deep models typically focus on specific dataset and task, limiting…

Signal Processing · Electrical Eng. & Systems 2025-09-03 Ang Li , Zikai Wang , Liuyin Yang , Zhenyu Wang , Tianheng Xu , Honglin Hu , Marc M. Van Hulle

We present ENSAM (Equivariant, Normalized, Segment Anything Model), a lightweight and promptable model for universal 3D medical image segmentation. ENSAM combines a SegResNet-based encoder with a prompt encoder and mask decoder in a…

Computer Vision and Pattern Recognition · Computer Science 2025-09-22 Elias Stenhede , Agnar Martin Bjørnstad , Arian Ranjbar