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Markov state models (MSMs) have been demonstrated to be a powerful method for computationally studying intramolecular processes such as protein folding and macromolecular conformational changes. In this article, we present a new approach to…

Biological Physics · Physics 2015-06-18 Matthew R. Perkett , Michael F. Hagan

As a relatively new field, network neuroscience has tended to focus on aggregate behaviours of the brain averaged over many successive experiments or over long recordings in order to construct robust brain models. These models are limited…

Neurons and Cognition · Quantitative Biology 2022-05-19 James Wilsenach , Katie Warnaby , Charlotte M. Deane , Gesine Reinert

We propose a new flexible tensor model for multiple-equation regression that accounts for latent regime changes. The model allows for dynamic coefficients and multi-dimensional covariates that vary across equations. We assume the…

Methodology · Statistics 2024-07-02 Roberto Casarin , Radu Craiu , Qing Wang

This paper investigates the role of high-dimensional information sets in the context of Markov switching models with time varying transition probabilities. Markov switching models are commonly employed in empirical macroeconomic research…

Econometrics · Economics 2019-05-07 Gregor Zens , Maximilian Böck

A stochastic hybrid system, also known as a switching diffusion, is a continuous-time Markov process with state space consisting of discrete and continuous parts. We consider parametric estimation of theQmatrix for the discrete state…

Probability · Mathematics 2020-10-14 Masaaki Fukasawa

In this paper, we consider linear state-space models with compressible innovations and convergent transition matrices in order to model spatiotemporally sparse transient events. We perform parameter and state estimation using a dynamic…

Machine Learning · Statistics 2016-10-21 Abbas Kazemipour , Ji Liu , Patrick Kanold , Min Wu , Behtash Babadi

State space models (SSMs) have recently achieved strong performance on long sequence modeling tasks while offering improved memory and computational efficiency compared to transformer based architectures. However, their evaluation has been…

Machine Learning · Computer Science 2026-03-13 Fatemeh Valeh , Monika Farsang , Radu Grosu , Gerhard Schütz

Modeling the dynamics of non-stationary stochastic systems requires balancing the representational power of deep learning with the mathematical transparency of classical models. While classical Markov transition operators provide explicit,…

Machine Learning · Computer Science 2026-05-07 Jan Rovirosa , Jesse Schmolze

As one of the most effective methods for cardiovascular disease (CVD) diagnosis, multi-lead Electrocardiogram (ECG) signals present a characteristic multi-sensor information fusion challenge that has been continuously researched in deep…

Signal Processing · Electrical Eng. & Systems 2025-09-04 Huaicheng Zhang , Ruoxin Wang , Chenlian Zhou , Jiguang Shi , Yue Ge , Zhoutong Li , Sheng Chang , Hao Wang , Jin He , Qijun Huang

We study the class of state-space models and perform maximum likelihood estimation for the model parameters. We consider a stochastic approximation expectation-maximization (SAEM) algorithm to maximize the likelihood function with the…

Computation · Statistics 2017-10-25 Umberto Picchini , Adeline Samson

Interval-censored multi-state data arise in many studies of chronic diseases, where the health status of a subject can be characterized by a finite number of disease states and the transition between any two states is only known to occur…

Methodology · Statistics 2022-09-19 Yu Gu , Donglin Zeng , Gerardo Heiss , D. Y. Lin

State Space Model (SSM) is a mathematical model used to describe and analyze the behavior of dynamic systems. This model has witnessed numerous applications in several fields, including control theory, signal processing, economics and…

Computer Vision and Pattern Recognition · Computer Science 2024-05-08 Xiao Liu , Chenxu Zhang , Lei Zhang

When clustering molecular dynamics (MD) trajectories into a few metastable conformational states, the Markov state models (MSMs) assumption of timescale separation between fast intrastate fluctuations and rarely occurring interstate…

Soft Condensed Matter · Physics 2025-01-17 Sofia Sartore , Franziska Teichmann , Gerhard Stock

Large Audio Language Models (LALM) combine the audio perception models and the Large Language Models (LLM) and show a remarkable ability to reason about the input audio, infer the meaning, and understand the intent. However, these systems…

Audio and Speech Processing · Electrical Eng. & Systems 2024-11-26 Saurabhchand Bhati , Yuan Gong , Leonid Karlinsky , Hilde Kuehne , Rogerio Feris , James Glass

The electricity sector is undergoing substantial transformations due to the rising electrification of demand, enhanced integration of renewable energy resources, and the emergence of new technologies. These changes are rendering the…

Machine Learning · Computer Science 2025-12-23 Ali Menati , Fatemeh Doudi , Dileep Kalathil , Le Xie

Forecasting in the real world requires integrating structured time-series data with unstructured textual information, but existing methods are architecturally limited by fixed input/output horizons and are unable to model or quantify…

Machine Learning · Computer Science 2025-10-27 Sungjun Cho , Changho Shin , Suenggwan Jo , Xinya Yan , Shourjo Aditya Chaudhuri , Frederic Sala

We propose a Bayesian hidden Markov model for analyzing time series and sequential data where a special structure of the transition probability matrix is embedded to model explicit-duration semi-Markovian dynamics. Our formulation allows…

Methodology · Statistics 2022-05-23 Beniamino Hadj-Amar , Jack Jewson , Mark Fiecas

State-space modeling has emerged as a powerful paradigm for sequence analysis in various tasks such as natural language processing, time-series forecasting, and signal processing. In this work, we propose an \emph{Adaptive State-Space…

Machine Learning · Computer Science 2025-07-31 Alice Zhang , Chao Li

Emerging applications such as AR are driving demands for machine intelligence capable of processing continuous and/or long-context inputs on local devices. However, currently dominant models based on Transformer architecture suffers from…

Hardware Architecture · Computer Science 2026-03-24 Saptarshi Mitra , Rachid Karami , Haocheng Xu , Sitao Huang , Hyoukjun Kwon

We propose a deep generative Markov State Model (DeepGenMSM) learning framework for inference of metastable dynamical systems and prediction of trajectories. After unsupervised training on time series data, the model contains (i) a…

Machine Learning · Statistics 2019-01-14 Hao Wu , Andreas Mardt , Luca Pasquali , Frank Noe