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Carbon ion therapy is one of the most advanced forms of radiotherapy, promising improved efficacy against resistant cancers. However, the high precision offered by the carbon ion Bragg peak requires precise knowledge of the beam range…

In the present paper we introduce a new accelerator concept for ions. The accelerator is nano-structured and can consist of a range of materials. It is capable of generating large ionic currents at moderate ion energies. The nano-structures…

Accelerator Physics · Physics 2022-12-27 Hartmut Ruhl , Georg Korn

Laser ion acceleration is a promising concept for generation of fast ions using a compact laser-solid interaction setup. In this study, we theoretically investigate the feasibility of ion acceleration from the interaction of petawatt-scale…

Plasma Physics · Physics 2022-01-19 K. V. Lezhnin , S. V. Bulanov

We investigate by particle-in-cell simulations in two and three dimensions the laser-plasma interaction and the proton acceleration in multilayer targets where a low density "near-critical" layer of a few micron thickness is added on the…

Plasma Physics · Physics 2015-06-03 Andrea Sgattoni , Pasquale Londrillo , Andrea Macchi , Matteo Passoni

We consider methods of charged particle acceleration by means of high-intensity lasers. As an application we discuss a laser booster for heavy ion beams provided, e.g. by the Dubna nuclotron. Simple estimates show that a cascade of crossed…

Accelerator Physics · Physics 2008-12-18 I. A. Egorova , A. V. Filatov , A. V. Prozorkevich , S. A. Smolyansky , D. B. Blaschke , M. Chubaryan

Laser-driven ion accelerators have the advantages of compact size, high density, and short bunch duration over conventional accelerators. Nevertheless, it is still challenging to simultaneously enhance the yield and quality of laser-driven…

Plasma Physics · Physics 2016-11-22 S. M. Weng , M. Liu , Z. M. Sheng , M. Murakami , M. Chen , L. L. Yu , J. Zhang

Charged particle therapy, or so-called hadrontherapy, is developing very rapidly. There is large pressure on the scientific community to deliver dedicated accelerators, providing the best possible treatment modalities at the lowest cost. In…

Accelerator Physics · Physics 2014-11-21 A. Garonna , U. Amaldi , R. Bonomi , D. Campo , A. Degiovanni , M. Garlasché , I. Mondino , V. Rizzoglio , S. Verdú Andrés

We report on an experimental study of proton acceleration by intense laser irradiation of micrometric bar targets, whose dimensions are transversely immersed in the laser focal volume and are longitudinally smaller than half its wavelength.…

We are in a golden age of progress in artificial intelligence (AI). Radiotherapy, due to its technology-intensive nature as well as direct human-machine interactions, is perfectly suited for benefitting from AI to enhance accuracy and…

Medical Physics · Physics 2022-11-21 Hao Peng , Chao Wu , Dan Nguyen , Jan Schuemann , Andrea Mairani , Yuehu Pu , Steve Jiang

Charged Particle Therapy is a technique for cancer treatment that exploits hadron beams, mostly protons and carbons. A critical issue is the monitoring of the dose released by the beam to the tumor and to the surrounding tissues. We present…

Proton therapy is a cancer treatment technique currently in growth worldwide. It offers advantages with respect to conventional X-ray and $\gamma$-ray radiotherapy, in particular, a better control of the dose deposition allowing to reach a…

Ion sources are a critical component of all particle accelerators. They create the initial beam that is accelerated by the rest of the machine. This paper will introduce the many methods of creating a beam for high-power hadron…

Accelerator Physics · Physics 2013-02-18 Dan Faircloth

The radiation pressure acceleration (RPA) of charged particles has been considered a challenging task in laser particle acceleration. Laser-driven proton/ion acceleration has attracted considerable interests due to its underlying physics…

To this day the interaction of high-intensity lasers with matter is considered to be a possible candidate for next generation particle accelerators. Within the LIGHT collaboration crucial work for the merging of a high-intensity laser…

Accelerator Physics · Physics 2018-12-26 J. Ding , D. Schumacher , D. Jahn , A. Blazevic , M. Roth

A superintense laser pulse illuminating a thin solid-density foil can, in principle, accelerate the entire foil, therefore yielding dense, collimated, and quasi-monoenergetic ion beams. These unique features render radiation pressure…

Plasma Physics · Physics 2020-02-27 Maitreyi Sangal , Matteo Tamburini

Understanding how the electronic excitation of DNA changes in response to different high-energy particles is central to advancing ion beam cancer therapy. While protons have been the predominant ion of choice in beam cancer therapy, heavier…

Soft Condensed Matter · Physics 2024-01-10 Christopher Shepard , Yosuke Kanai

The `Laser-hybrid Accelerator for Radiobiological Applications', LhARA, is conceived as a novel, uniquely-flexible facility dedicated to the study of radiobiology. The technologies demonstrated in LhARA, which have wide application, will be…

Protontherapy is hadrontherapy fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct…

Radiation damage induced by ion beams is traditionally treated at different levels of theoretical approaches, for the different scales and mechanisms involved.We present here details of a combined approach that, from a method at a…

FLASH radiotherapy (FLASH-RT) is a new modality of radiotherapy by delivering doses with ultra-high dose rates. FLASH-RT has the ability to suppress tumor growth while sparing normal tissues, known as the FLASH effect. Although FLASH effect…