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Particle therapy is a well established clinical treatment of tumors. More than one hundred particle therapy centers are in operation world wide. The advantage of using hadrons like protons or carbon ions as particles for tumor irradiation…

Ion acceleration driven by superintense laser pulses is attracting an impressive and steadily increasing effort. Motivations can be found in the potential for a number of foreseen applications and in the perspective to investigate novel…

Plasma Physics · Physics 2015-06-15 Andrea Macchi , Marco Borghesi , Matteo Passoni

The acceleration of ions from ultra-thin foils has been investigated using 250 TW, sub-ps laser pulses, focused on target at intensities up to $3\times10^{20} \Wcm2$. The ion spectra show the appearance of narrow band features for proton…

Proton acceleration by using a 620-TW, 18-J laser pulse of peak intensity of $5\times 10^{21}$ W/cm$^{2}$ irradiating a disk target is examined using three-dimensional particle-in-cell simulations. It is shown that protons are accelerated…

Plasma Physics · Physics 2015-06-15 Toshimasa Morita

In particle therapy with protons a cyclotron is one of the most used particle accelerators. Here it will be explained how a cyclotron works, some beam dynamics aspects, its major subsystems, as well as the advantages and disadvantages of a…

Medical Physics · Physics 2018-04-24 Jacobus Maarten Schippers

Radiotherapy is one of the main methods in the successful treatment of cancer. The tumor is irradiated with photons or charged particles (e.g. protons), and in the case of massive charged particles, the treatment results in less unnecessary…

Medical Physics · Physics 2019-03-20 Monika Varga-Kofarago

Laser-driven ion acceleration is an attractive technique for compact high-energy ion sources. Currently, among various physical and technical issues to be solved, the boost of ion energy and the reduction of energy spread represent the key…

Plasma Physics · Physics 2022-07-19 Xing-Long Zhu , Wei-Yuan Liu , Min Chen , Su-Ming Weng , Paul McKenna , Zheng-Ming Sheng , Jie Zhang

The radiotherapy of malignant diseases has reached much progress during the past decade. Thus, intensity modulated radiation therapy (IMRT) and VMAT (Rapidarc) now belong to the standard modalities of tumor treatment with high energy…

Medical Physics · Physics 2016-11-15 W. Ulmer , A. Carabe-Fernandez

During the past decade, the interaction of high-intensity lasers with solid targets has attracted much interest, regarding its potential in accelerating charged particles. In spite of tremendous progress in laser-plasma based acceleration,…

Accelerator Physics · Physics 2010-12-01 Benjamin J. Galow , Zoltán Harman , Christoph H. Keitel

Proton acceleration by high-intensity laser pulses from ultra-thin foils for hadron therapy is discussed. With the improvement of the laser intensity contrast ratio to 10-11 achieved on Hercules laser at the University of Michigan, it…

Conventional cancer therapies include surgery, radiation therapy, chemotherapy, and, more recently, immunotherapy. These modalities are often combined to improve the therapeutic index. The general concept of radiation therapy is to increase…

Laser accelerated protons can be a complimentary source for treatment of oncological diseases to the existing hadron therapy facilities. We demonstrate how the protons, accelerated from near-critical density plasmas by laser pulses having…

Efficient laser ion acceleration requires high laser intensities, which can only be obtained by tightly focusing laser radiation. In the radiation pressure acceleration regime, where the tightly focused laser driver leads to the appearance…

Ion beam analysis techniques are among the most powerful tools for advanced material characterization. Despite their growing relevance in a widening number of fields, most ion beam analysis facilities still rely on the oldest accelerator…

Plasma Physics · Physics 2019-03-06 Matteo Passoni , Luca Fedeli , Francesco Mirani

Direct laser acceleration of ions by short frequency-chirped laser pulses is investigated theoretically. We demonstrate that intense beams of ions with a kinetic energy broadening of about 1 % can be generated. The chirping of the laser…

Accelerator Physics · Physics 2015-02-10 Jian-Xing Li , Benjamin Galow , Christoph H. Keitel , Zoltán Harman

Laser-driven ion acceleration provides ultra-short, high-charge, low-emittance beams, which are desirable for a wide range of high-impact applications. Yet after decades of research, a significant increase in maximum ion energy is still…

A theory for laser ion acceleration is presented to evaluate the maximum ion energy in the interaction of ultrahigh contrast (UHC) intense laser with a nanometer-scale foil. In this regime the energy of ions may be directly related to the…

Plasma Physics · Physics 2015-05-13 X. Q. Yan , T. Tajima , M. Hegelich , L. Yin , D. Habs

Radiation therapy with carbon ions is a novel technique of cancer radiotherapy, applicable in particular to treating radioresistant tumours at difficult localisations. Therapy planning, where the medical physicist, following the medical…

Medical Physics · Physics 2014-10-07 Leszek Grzanka

We demonstrate generation of 10-20 MeV/u ions with a compact 4 TW laser using a gas target mixed with submicron clusters, corresponding to tenfold increase in the ion energies compared to previous experiments with solid targets. It is…

Proton and carbon ion therapy is an emerging technique used for the treatment of solid cancers. The monitoring of the dose delivered during such treatments is still a matter of research. A possible technique exploits the information…