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The current advances in generative AI for learning large neural network models with the capability to produce essays, images, music and even 3D assets from text prompts create opportunities for a manifold of disciplines. In the present…
Machine learning methods adapt the parameters of a model, constrained to lie in a given model class, by using a fixed learning procedure based on data or active observations. Adaptation is done on a per-task basis, and retraining is needed…
We consider the problem of learning structures and parameters of Continuous-time Bayesian Networks (CTBNs) from time-course data under minimal experimental resources. In practice, the cost of generating experimental data poses a bottleneck,…
This paper surveys foundation models for AI-enabled biological design, focusing on recent developments in applying large-scale, self-supervised models to tasks such as protein engineering, small molecule design, and genomic sequence design.…
The field of meta-learning seeks to improve the ability of today's machine learning systems to adapt efficiently to small amounts of data. Typically this is accomplished by training a system with a parametrized update rule to improve a…
Directed evolution is an iterative laboratory process of designing proteins with improved function by iteratively synthesizing new protein variants and evaluating their desired property with expensive and time-consuming biochemical…
The unification of statistical (data-driven) and symbolic (knowledge-driven) methods is widely recognised as one of the key challenges of modern AI. Recent years have seen large number of publications on such hybrid neuro-symbolic AI…
As modern software systems expand in scale and complexity, the challenges associated with their modeling and formulation grow increasingly intricate. Traditional approaches often fall short in effectively addressing these complexities,…
Deep learning has transformed protein design, enabling accurate structure prediction, sequence optimization, and de novo protein generation. Advances in single-chain protein structure prediction via AlphaFold2, RoseTTAFold, ESMFold, and…
Over the past decade, data science and machine learning has grown from a mysterious art form to a staple tool across a variety of fields in academia, business, and government. In this paper, we introduce the concept of tree-based pipeline…
Generative AI, specifically text-to-image models, have revolutionized interior architectural design by enabling the rapid translation of conceptual ideas into visual representations from simple text prompts. While generative AI can produce…
Producing an artificial general intelligence (AGI) has been an elusive goal in artificial intelligence (AI) research for some time. An AGI would have the capability, like a human, to be exposed to a new problem domain, learn about it and…
This paper asks whether our relationship with nature can move from human dominance to genuine interdependence, and whether artificial intelligence (AI) can mediate that shift. We examine a new ecological-design paradigm in which AI…
Large language models (LLMs) such as ChatGPT have recently demonstrated significant potential in mathematical abilities, providing valuable reasoning paradigm consistent with human natural language. However, LLMs currently have difficulty…
Numerical simulations have revolutionized the industrial design process by reducing prototyping costs, design iterations, and enabling product engineers to explore the design space more efficiently. However, the growing scale of simulations…
In the present article, we propose a paradigm shift on evolving Artificial Neural Networks (ANNs) towards a new bio-inspired design that is grounded on the structural properties, interactions, and dynamics of protein networks (PNs): the…
Computational models have emerged as powerful tools for multi-scale energy modeling research at the building and urban scale, supporting data-driven analysis across building and urban energy systems. However, these models require large…
The potential of synthetic biology techniques for designing complex cellular circuits able to solve complicated computations opens a whole domain of exploration, beyond experiments and theory. Such cellular circuits could be used to carry…
Engineering design research integrating artificial intelligence (AI) into computer-aided design (CAD) and computer-aided engineering (CAE) is actively being conducted. This study proposes a deep learning-based CAD/CAE framework in the…
As advancements in artificial intelligence (AI) propel progress in the life sciences, they may also enable the weaponisation and misuse of biological agents. This article differentiates two classes of AI tools that could pose such…