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Modern life sciences research is increasingly relying on artificial intelligence approaches to model biological systems, primarily centered around the use of machine learning (ML) models. Although ML is undeniably useful for identifying…

Predicting high-fidelity future human poses, from a historically observed sequence, is decisive for intelligent robots to interact with humans. Deep end-to-end learning approaches, which typically train a generic pre-trained model on…

Computer Vision and Pattern Recognition · Computer Science 2023-04-14 Qiongjie Cui , Huaijiang Sun , Jianfeng Lu , Bin Li , Weiqing Li

Autoregressive Sequence-To-Sequence models are the foundation of many Deep Learning achievements in major research fields such as Vision and Natural Language Processing. Despite that, they still present significant limitations. For…

Computation and Language · Computer Science 2024-08-27 Jia Cheng Hu , Roberto Cavicchioli , Alessandro Capotondi

The impressive performance exhibited by modern machine learning models hinges on the ability to train such models on a very large amounts of labeled data. However, since access to large volumes of labeled data is often limited or expensive,…

Machine Learning · Computer Science 2021-04-27 Neta Shoham , Haim Avron

Artificial intelligence (AI)-driven methods can vastly improve the historically costly drug design process, with various generative models already in widespread use. Generative models for de novo drug design, in particular, focus on the…

Biomolecules · Quantitative Biology 2024-06-27 Xiangru Tang , Howard Dai , Elizabeth Knight , Fang Wu , Yunyang Li , Tianxiao Li , Mark Gerstein

In drug discovery, highly automated high-throughput laboratories are used to screen a large number of compounds in search of effective drugs. These experiments are expensive, so one might hope to reduce their cost by only experimenting on a…

Machine Learning · Computer Science 2025-04-15 Ihor Neporozhnii , Julien Roy , Emmanuel Bengio , Jason Hartford

Generative AI models hold great potential in creating synthetic brain MRIs that advance neuroimaging studies by, for example, enriching data diversity. However, the mainstay of AI research only focuses on optimizing the visual quality (such…

Image and Video Processing · Electrical Eng. & Systems 2023-10-10 Wei Peng , Tomas Bosschieter , Jiahong Ouyang , Robert Paul , Ehsan Adeli , Qingyu Zhao , Kilian M. Pohl

Deep learning models in medical imaging often encounter challenges when adapting to new clinical settings unseen during training. Test-time adaptation offers a promising approach to optimize models for these unseen domains, yet its…

Machine Learning · Computer Science 2024-10-28 Sameer Ambekar , Julia A. Schnabel , Cosmin I. Bercea

Declarative modeling uses symbolic expressions to represent models. With such expressions one can formalize high-level mathematical computations on models that would be difficult or impossible to perform directly on a lower-level simulation…

Quantitative Methods · Quantitative Biology 2019-07-02 Eric Mjolsness

Directed evolution is a molecular biology technique that is transforming protein engineering by creating proteins with desirable properties and functions. However, it is experimentally impossible to perform the deep mutational scanning of…

Biomolecules · Quantitative Biology 2023-06-09 Yuchi Qiu , Guo-Wei Wei

The design of high-performance optical systems remains a specialized domain gated by the limited availability of expert engineers, creating a bottleneck that stalls innovation despite the growing demand for imaging hardware. While deep…

Optics · Physics 2026-02-17 Roy Maman , David Ohana , Jacob Engelberg , Uriel Levy

Biological engineering, the convergence between engineering and biology, is at the forefront of significant advances in healthcare, agriculture, and environmental sustainability, making it highly relevant to current scientific and societal…

Other Quantitative Biology · Quantitative Biology 2026-02-17 Ulrike A. Nuber , Viktor Stein

In meta-learning approaches, it is difficult for a practitioner to make sense of what kind of representations the model employs. Without this ability, it can be difficult to both understand what the model knows as well as to make meaningful…

Machine Learning · Computer Science 2022-04-05 Pedro Sandoval-Segura , Wallace Lawson

The research of metamaterials has achieved enormous success in the manipulation of light in an artificially prescribed manner using delicately designed sub-wavelength structures, so-called meta-atoms. Even though modern numerical methods…

Optics · Physics 2019-01-31 Wei Ma , Feng Cheng , Yihao Xu , Qinlong Wen , Yongmin Liu

This paper presents ExplainableFold, an explainable AI framework for protein structure prediction. Despite the success of AI-based methods such as AlphaFold in this field, the underlying reasons for their predictions remain unclear due to…

Artificial Intelligence · Computer Science 2023-06-12 Juntao Tan , Yongfeng Zhang

Deep learning offers transformative potential in medical imaging, yet its clinical adoption is frequently hampered by challenges such as data scarcity, distribution shifts, and the need for robust task generalization. Prompt-based…

Image and Video Processing · Electrical Eng. & Systems 2025-07-03 Hao Yang , Xinlong Liang , Zhang Li , Yue Sun , Zheyu Hu , Xinghe Xie , Behdad Dashtbozorg , Jincheng Huang , Shiwei Zhu , Luyi Han , Jiong Zhang , Shanshan Wang , Ritse Mann , Qifeng Yu , Tao Tan

Deep learning has redefined the field of artificial intelligence (AI) thanks to the rise of artificial neural networks, which are architectures inspired by their neurological counterpart in the brain. Through the years, this dualism between…

Machine Learning · Computer Science 2023-02-21 Tommaso Salvatori , Yuhang Song , Thomas Lukasiewicz , Rafal Bogacz , Zhenghua Xu

We propose an automated genomic interpretation module that transforms raw DNA sequences into actionable, interpretable decisions suitable for integration into medical automation and robotic systems. Our framework combines Chaos Game…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Zijun Li , Jinchang Zhang , Ming Zhang , Guoyu Lu

Meaning has been called the "holy grail" of a variety of scientific disciplines, ranging from linguistics to philosophy, psychology and the neurosciences. The field of Artifical Intelligence (AI) is very much a part of that list: the…

Artificial Intelligence · Computer Science 2016-10-25 Douwe Kiela , Luana Bulat , Anita L. Vero , Stephen Clark

Deep learning techniques have been widely used in autonomous driving systems for the semantic understanding of urban scenes. However, they need a huge amount of labeled data for training, which is difficult and expensive to acquire. A…

Computer Vision and Pattern Recognition · Computer Science 2020-03-03 Umberto Michieli , Matteo Biasetton , Gianluca Agresti , Pietro Zanuttigh