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In the field of multiple hypothesis testing, combining p-values represents a fundamental statistical method. The Cauchy combination test (CCT) (Liu and Xie, 2020) excels among numerous methods for combining p-values with powerful and…

Methodology · Statistics 2024-10-17 Yanyan Ouyang , Xingwei Liu , Lixing Zhu , Wangli Xu

Combining dependent p-values poses a long-standing challenge in statistical inference, particularly when aggregating findings from multiple methods to enhance signal detection. Recently, p-value combination tests based on regularly…

Methodology · Statistics 2025-04-22 Lin Gui , Yuchao Jiang , Jingshu Wang

It is often of interest to test a global null hypothesis using multiple, possibly dependent $p$-values by combining their strengths while controlling the type-I error. Recently, several heavy-tailed combination tests, such as the harmonic…

Statistics Theory · Mathematics 2026-03-25 Parijat Chakraborty , F. Richard Guo , Kerby Shedden , Stilian Stoev

Heavy-tailed combination tests, such as the Cauchy combination test and harmonic mean p-value method, are widely used for testing global null hypotheses by aggregating dependent p-values. However, their theoretical guarantees under general…

Statistics Theory · Mathematics 2025-08-11 Lin Gui , Tiantian Mao , Jingshu Wang , Ruodu Wang

The issue of combining individual $p$-values to aggregate multiple small effects is prevalent in many scientific investigations and is a long-standing statistical topic. Many classical methods are designed for combining independent and…

Methodology · Statistics 2021-09-08 Yusi Fang , George C. Tseng , Chung Chang

Aggregating multiple effects is often encountered in large-scale data analysis where the fraction of significant effects is generally small. Many existing methods cannot handle it effectively because of lack of computational accuracy for…

Methodology · Statistics 2022-08-03 Mingya Long , Zhengbang Li , Wei Zhang , Qizhai Li

The Cauchy combination test (CCT) is a $p$-value combination method used in multiple-hypothesis testing and is robust under dependence structures. This study aims to evaluate the CCT for independent and correlated count data where the…

Methodology · Statistics 2025-04-22 Huda Alsulami , Silvia Liverani

Combining individual p-values to aggregate multiple small effects has a long-standing interest in statistics, dating back to the classic Fisher's combination test. In modern large-scale data analysis, correlation and sparsity are common…

Methodology · Statistics 2018-11-30 Yaowu Liu , Jun Xie

Cauchy combination test has been widely used for combining correlated p-values, but it may fail to work under certain scenarios. We propose a truncated Cauchy combination test (TCCT) which focus on combining p-values with arbitrary…

Methodology · Statistics 2025-06-17 Bo Chen , Wei Xu , Xin Gao

Handling multiplicity without losing much power has been a persistent challenge in various fields that often face the necessity of managing numerous statistical tests simultaneously. Recently, $p$-value combination methods based on…

Statistics Theory · Mathematics 2024-02-06 Yeonwoo Rho

We leverage recent advances in heavy-tail approximations for global hypothesis testing with dependent studies to construct approximate confidence regions without modeling or estimating their dependence structures. A non-rejection region is…

Methodology · Statistics 2025-10-06 Tianle Liu , Xiao-Li Meng , Natesh S. Pillai

The Cauchy combination test (CCT) is widely used because it gives a closed-form combined $p$-value and is known to be asymptotically valid as the nominal level $\alpha\downarrow0$ under broad dependence structures. We study a different…

Statistics Theory · Mathematics 2026-03-25 Hirofumi Ota

We introduce a novel meta-analysis framework to combine dependent tests under a general setting, and utilize it to synthesize various microbiome association tests that are calculated from the same dataset. Our development builds upon the…

Methodology · Statistics 2024-04-16 Xiufan Yu , Linjun Zhang , Arun Srinivasan , Min-ge Xie , Lingzhou Xue

This paper proposes a stable combination test, which is a natural extension of Cauchy combination tests by Liu and Xie (2020). Similarly to the Cauchy combination test, our stable combination test is simple to compute, enjoys good sizes,…

Methodology · Statistics 2021-08-19 Xing Ling , Yeonwoo Rho

In this article, we consider the problem of simultaneous testing of hypotheses when the individual test statistics are not necessarily independent. Specifically, we consider the problem of simultaneous testing of point null hypotheses…

Statistics Theory · Mathematics 2018-07-17 Prasenjit Ghosh , Arijit Chakrabarti

Recent work has proposed the use of a composite hypothesis Hoeffding test for statistical anomaly detection. Setting an appropriate threshold for the test given a desired false alarm probability involves approximating the false alarm…

Information Theory · Computer Science 2016-09-19 Jing Zhang , Ioannis Ch. Paschalidis

Testing high-dimensional quantile regression coefficients is crucial, as tail quantiles often reveal more than the mean in many practical applications. Nevertheless, the sparsity pattern of the alternative hypothesis is typically unknown in…

Methodology · Statistics 2025-12-29 Ping Zhao , Zhenyu Liu , Dan Zhuang

This paper develops a novel methodology for testing the goodness-of-fit of sparse parametric regression models based on projected empirical processes and p-value combination, where the covariate dimension may substantially exceed the sample…

Statistics Theory · Mathematics 2026-01-05 Falong Tan , Shan Tang , Lixing Zhu

This paper proposes general methods for the problem of multiple testing of a single hypothesis, with a standard goal of combining a number of p-values without making any assumptions about their dependence structure. An old result by…

Statistics Theory · Mathematics 2019-10-09 Vladimir Vovk , Ruodu Wang

We introduce a rigorous and sensitive significance test for hyperuniformity that yields reliable results even from a single sample. Our approach is based on a detailed analysis of the empirical Fourier transform of a stationary point…

Statistics Theory · Mathematics 2026-03-23 Michael A. Klatt , Günter Last , Norbert Henze
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