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Protein sequence generation for engineering requires samples that are biophysically plausible and, when targeting a family/domain, remain recognizable members while exploring within-family diversity. Current discrete generative models…

Computational Engineering, Finance, and Science · Computer Science 2026-05-25 Langzhang Liang , Ming Yang , Yi Feng , Junfan Li , Shirui Pan , Yinghui Xu , Tianlei Ying , Yizhen Zheng , Zenglin Xu

We present Synthesizer, a fast, flexible, modular and extensible platform for modelling synthetic astrophysical observables. Synthesizer can be used for a number of applications, but is predominantly designed for generating mock observables…

Instrumentation and Methods for Astrophysics · Physics 2025-10-14 Christopher C. Lovell , William J. Roper , Aswin P. Vijayan , Stephen M. Wilkins , Sophie Newman , Louise Seeyave

Computer vision techniques have immense potential for materials design applications. In this work, we introduce an integrated and general-purpose AtomVision library that can be used to generate, curate scanning tunneling microscopy (STM)…

Materials Science · Physics 2023-03-06 Kamal Choudhary , Ramya Gurunathan , Brian DeCost , Adam Biacchi

Programmable Matter (PM) has been widely investigated in recent years. It refers to some kind of matter with the ability to change its physical properties (e.g., shape or color) in a programmable way. One reference model is certainly…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-08-01 Alfredo Navarra , Francesco Piselli

PolyMAPS is an open-source library that helps researchers to initialize LAMMPS molecular dynamics simulations. It introduces an integrated workflow by combining preparation, launching, visualization, and analysis into a single Jupyter…

Chemical Physics · Physics 2023-11-14 Xiaoli Yan , Santanu Chaudhuri

Many disciplines pose natural-language research questions over large document collections whose answers typically require structured evidence, traditionally obtained by manually designing an annotation schema and exhaustively labeling the…

Computation and Language · Computer Science 2026-04-13 Shahar Levy , Eliya Habba , Reshef Mintz , Barak Raveh , Renana Keydar , Gabriel Stanovsky

Due to the complex specifications of current electronic systems, design decisions need to be explored automatically. However, the exploration process is a complex task given the plethora of design choices such as the selection of…

Hardware Architecture · Computer Science 2023-06-22 Sergio Vinagrero Gutiérrez , Giorgio Di Natale , Elena-Ioana Vatajelu

Machine learning interatomic potentials (MLIPs) have become powerful tools to extend molecular simulations beyond the limits of quantum methods, offering near-quantum accuracy at much lower computational cost. Yet, developing reliable MLIPs…

Materials Science · Physics 2025-12-30 Adam Lahouari , Jutta Rogal , Mark E. Tuckerman

Visual programming has the potential of providing novice programmers with a low-code experience to build customized processing pipelines. Existing systems typically require users to build pipelines from scratch, implying that novice users…

Numerical software in computational science and engineering often relies on highly-optimized building blocks from libraries such as BLAS and LAPACK, and while such libraries provide portable performance for a wide range of computing…

Mathematical Software · Computer Science 2019-06-21 Daniele G. Spampinato , Diego Fabregat-Traver , Markus Püschel , Paolo Bientinesi

The development of AI-assisted chemical synthesis tools requires comprehensive datasets covering diverse reaction types, yet current high-throughput experimental (HTE) approaches are expensive and limited in scope. Chemical literature…

Information Retrieval · Computer Science 2025-07-01 Kexin Chen , Yuyang Du , Junyou Li , Hanqun Cao , Menghao Guo , Xilin Dang , Lanqing Li , Jiezhong Qiu , Pheng Ann Heng , Guangyong Chen

Analogy-making is central to human cognition, allowing us to adapt to novel situations -- an ability that current AI systems still lack. Most analogy datasets today focus on simple analogies (e.g., word analogies); datasets including…

Computation and Language · Computer Science 2024-05-15 Oren Sultan , Yonatan Bitton , Ron Yosef , Dafna Shahaf

Machine-learning models are increasingly used to predict properties of atoms in chemical systems. There have been major advances in developing descriptors and regression frameworks for this task, typically starting from (relatively) small…

Chemical Physics · Physics 2022-11-30 John L. A. Gardner , Zoé Faure Beaulieu , Volker L. Deringer

Analysis pipelines commonly use high-level technologies that are popular when created, but are unlikely to be readable, executable, or sustainable in the long term. A set of criteria is introduced to address this problem: Completeness (no…

While Large Language Models (LLMs) have shown exceptional generalization capabilities, their ability to process graph data, such as molecular structures, remains limited. To bridge this gap, this paper proposes Graph2Token, an efficient…

Machine Learning · Computer Science 2025-03-11 Runze Wang , Mingqi Yang , Yanming Shen

Scientific workflows in computational chemistry and materials science typically involve multiple interdependent steps, such as model preparation, system construction, simulation execution, and data analysis, that researchers have refined…

Automated machine learning makes it easier for data scientists to develop pipelines by searching over possible choices for hyperparameters, algorithms, and even pipeline topologies. Unfortunately, the syntax for automated machine learning…

Machine Learning · Computer Science 2020-07-07 Guillaume Baudart , Martin Hirzel , Kiran Kate , Parikshit Ram , Avraham Shinnar

Recent advances in machine learning for molecules exhibit great potential for facilitating drug discovery from in silico predictions. Most models for molecule generation rely on the decomposition of molecules into frequently occurring…

Chemical Physics · Physics 2023-11-08 Leon Hetzel , Johanna Sommer , Bastian Rieck , Fabian Theis , Stephan Günnemann

In this paper, we propose a new compositional tool that will generate a musical outline of speech recorded/provided by the user for use as a musical building block in their compositions. The tool allows any user to use their own speech to…

Sound · Computer Science 2021-08-03 Jason d'Eon , Sri Harsha Dumpala , Chandramouli Shama Sastry , Dani Oore , Sageev Oore

Molecule generation is a challenging open problem in cheminformatics. Currently, deep generative approaches addressing the challenge belong to two broad categories, differing in how molecules are represented. One approach encodes molecular…

Machine Learning · Statistics 2020-11-02 Marco Podda , Davide Bacciu , Alessio Micheli
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