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As real-world datasets become more complex and heterogeneous, supervised learning is often bottlenecked by input representation design. Modeling multimodal data, such as time-series, free text, and structured records, often requires…

Artificial Intelligence · Computer Science 2026-05-22 Ilker Demirel , Lawrence Shi , Zeshan Hussain , David Sontag

One of the key requirements for incorporating machine learning into the drug discovery process is complete reproducibility and traceability of the model building and evaluation process. With this in mind, we have developed an end-to-end…

With the recent advances in machine learning for quantum chemistry, it is now possible to predict the chemical properties of compounds and to generate novel molecules. Existing generative models mostly use a string- or graph-based…

Biomolecules · Quantitative Biology 2020-10-14 Vitali Nesterov , Mario Wieser , Volker Roth

Today's analog/mixed-signal (AMS) integrated circuit (IC) designs demand substantial manual intervention. The advent of multimodal large language models (MLLMs) has unveiled significant potential across various fields, suggesting their…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Zhuofu Tao , Yichen Shi , Yiru Huo , Rui Ye , Zonghang Li , Li Huang , Chen Wu , Na Bai , Zhiping Yu , Ting-Jung Lin , Lei He

The Open Knowledgebase of Interatomic Models (OpenKIM) is an NSF Science Gateway that archives fully functional computer implementations of interatomic models (potentials and force fields) and simulation codes that use them to compute…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-05-31 Daniel S. Karls , Steven M. Clark , Brendon A. Waters , Ryan S. Elliott , Ellad B. Tadmor

This research paper is proposing the idea of pseudo code representation to molecular programming used in designing molecular electronics devices. Already the schematic representation of logical gates like AND, OR, NOT etc.from molecular…

Programming Languages · Computer Science 2010-05-24 Manas Ranjan Pradhan , E. G. Rajan

Recent advancements in large language models (LLMs) have demonstrated impressive performance in molecular generation, which offers potential to accelerate drug discovery. However, the current LLMs overlook a critical requirement for drug…

Machine Learning · Computer Science 2025-02-18 Hyosoon Jang , Yunhui Jang , Jaehyung Kim , Sungsoo Ahn

Generative models hold great promise for small molecule discovery, significantly increasing the size of search space compared to traditional in silico screening libraries. However, most existing machine learning methods for small molecule…

Graphs are ubiquitous data structures for representing interactions between entities. With an emphasis on the use of graphs to represent chemical molecules, we explore the task of learning to generate graphs that conform to a distribution…

Machine Learning · Computer Science 2019-03-08 Qi Liu , Miltiadis Allamanis , Marc Brockschmidt , Alexander L. Gaunt

Designing molecular structures with desired chemical properties is an essential task in drug discovery and material design. However, finding molecules with the optimized desired properties is still a challenging task due to combinatorial…

Biomolecules · Quantitative Biology 2023-02-02 Masatsugu Yamada , Mahito Sugiyama

The rise of social media platforms has brought about a new digital culture called memes. Memes, which combine visuals and text, can strongly influence public opinions on social and cultural issues. As a result, people have become interested…

Computation and Language · Computer Science 2023-12-12 Ming Shan Hee , Aditi Kumaresan , Nguyen Khoi Hoang , Nirmalendu Prakash , Rui Cao , Roy Ka-Wei Lee

Generating a novel and optimized molecule with desired chemical properties is an essential part of the drug discovery process. Failure to meet one of the required properties can frequently lead to failure in a clinical test which is costly.…

Machine Learning · Computer Science 2020-10-28 Bonggun Shin , Sungsoo Park , JinYeong Bak , Joyce C. Ho

Polymers play a crucial role in the development of engineering materials, with applications ranging from mechanical to biomedical fields. However, the limited polymerization processes constrain the variety of organic building blocks that…

Soft Condensed Matter · Physics 2024-12-13 Debasish Mohanty , V Shreyas , Akshaya Palai , Bharath Ramsundar

Motivation: Modern genomics laboratories generate massive volumes of sequencing data, often resulting in significant storage costs. Genomics storage consists of duplicate files, temporary processing files, and redundant intermediate data.…

Genomics · Quantitative Biology 2025-11-27 Margot Celerie , Andrew Oldfield , William Ritchie

In this work we describe a simple MATLAB based language which allows to create randomized multiple choice questions with minimal effort. This language has been successfully tested at Flinders University by the author in a number of…

Computers and Society · Computer Science 2020-07-01 Nurulla Azamov

Recent approaches in skill matching, employing synthetic training data for classification or similarity model training, have shown promising results, reducing the need for time-consuming and expensive annotations. However, previous…

Computation and Language · Computer Science 2024-02-06 Antoine Magron , Anna Dai , Mike Zhang , Syrielle Montariol , Antoine Bosselut

AMDAT (Amorphous Molecular Dynamics Analysis Toolkit) is an open-source C++ toolkit for post-processing molecular dynamics trajectories, focused on high-performance static and dynamic analyses of amorphous, glassy, and polymer materials,…

Materials Science · Physics 2026-02-06 Pierre Kawak , William F. Drayer , David S. Simmons

Fully automated astronomical data calibration and imaging pipelines are difficult to develop without a good prototyping method which permits to bridge the time between observatory commissioning and the moment when the special features and…

Instrumentation and Methods for Astrophysics · Physics 2021-12-21 Dirk Petry

DScribe is a software package for machine learning that provides popular feature transformations ("descriptors") for atomistic materials simulations. DScribe accelerates the application of machine learning for atomistic property prediction…

We present work flows and a software module for machine learning model building in surface science and heterogeneous catalysis. This includes fingerprinting atomic structures from 3D structure and/or connectivity information, it includes…