Related papers: Answering some questions about structured illumina…
Light-sheet microscopes must compromise between field of view, optical sectioning, resolution, and detection efficiency. High-numerical-aperture (NA) detection objective lenses provide high resolution but their narrow depth of field fails…
In a previous paper we described a method of estimating the single-measurement bias to be expected in astrometric observations of targets in crowded fields with the future Space Interferometry Mission (SIM). That study was based on a…
This thesis centres on the development of multidimensional fluorescence imaging tools, with a particular emphasis on fluorescence lifetime imaging (FLIM) microscopy for application to biological research. The key aspects of this thesis are…
Single-image super-resolution (SISR) is a canonical problem with diverse applications. Leading methods like SRGAN produce images that contain various artifacts, such as high-frequency noise, hallucinated colours and shape distortions, which…
We present a multimodal approach for measuring the three-dimensional (3D) refractive index (RI) and fluorescence distributions of live cells by combining optical diffraction tomography (ODT) and 3D structured illumination microscopy (SIM).…
In digital imaging, enhancing visual content in poorly lit environments is a significant challenge, as images often suffer from inadequate brightness, hidden details, and an overall reduction in quality. This issue is especially critical in…
Given an image, we wish to produce an image of larger size with significantly more pixels and higher image quality. This is generally known as the Single Image Super-Resolution (SISR) problem. The idea is that with sufficient training data…
The use of the structural similarity index (SSIM) is widespread. For almost two decades, it has played a major role in image quality assessment in many different research disciplines. Clearly, its merits are indisputable in the research…
Many microscopy applications are limited by the total amount of usable light and are consequently challenged by the resulting levels of noise in the acquired images. This problem is often addressed via (supervised) deep learning based…
Biological and biomedical samples are routinely examined using focused two-photon (2P) fluorescence microscopy due to its intrinsic axial sectioning and reduced out-of-focus bleaching. However, 2P imaging often requires excitation…
Diffusion-weighted magnetic resonance imaging (DW-MRI) can be used to characterise the microstructure of the nervous tissue, e.g. to delineate brain white matter connections in a non-invasive manner via fibre tracking. Magnetic Resonance…
Fluorescence microscopy is an important and extensively utilised tool for imaging biological systems. However, the image resolution that can be obtained has a limit as defined through the laws of diffraction. Demand for improved resolution…
Super-resolution microscopy overcomes the diffraction limit of conventional light microscopy in spatial resolution. By providing novel spatial or spatio-temporal information on biological processes at nanometer resolution with molecular…
Stacked intelligent metasurface (SIM) has emerged as a technology enabling wave domain beamforming through multiple stacked reconfigurable intelligent surfaces (RISs). SIM has been implemented so far with diagonal RIS (D-RIS), while SIM…
In this paper, a method for increasing the temporal resolution of a temporal imaging system has been developed. Analogously to the conventional spatial imaging systems in which resolution limit is due to the finite aperture of the lens, in…
We report a new coherent imaging technique, termed ptychographic structured modulation (PSM), for quantitative super-resolution microscopy. In this technique, we place a thin diffuser (i.e., a scattering lens) in between the sample and the…
We introduce a structured illumination technique for dark-field x-ray microscopy optimized for three-dimensional imaging of ordered materials at sub-micrometer length scales. Our method utilizes a coded aperture to spatially modulate the…
The Structural Similarity Index (SSIM) is generally considered to be a milestone in the recent history of Image Quality Assessment (IQA). Alas, SSIM's accepted development from the product of three heuristic factors continues to obscure…
Imaging is indispensable for nearly every field of science, engineering, technology, and medicine. However, measurement noise and stochastic distortions pose fundamental limits to accessible spatiotemporal information despite impressive…
We present a computational method for full-range interferometric synthetic aperture microscopy (ISAM) under dispersion encoding. With this, one can effectively double the depth range of optical coherence tomography (OCT), whilst…