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Microtubules (MTs) are filamentous protein polymers roughly 25 nm in diameter. Ubiquitous in eukaryotes, MTs are well known for their structural role but also act as actuators, sensors, and, in association with other proteins, checkpoint…

Optics · Physics 2017-08-01 Q. Tyrell Davis

WIMP-nucleon cross sections below 10^(-9) pb may be probed by ton-scale experiments with low thresholds and background rates ~20 events per year. An array of cryogenic detectors ("CryoArray") could perform well enough to reach this goal.…

Astrophysics · Physics 2009-11-07 R. W. Schnee , D. S. Akerib , R. J. Gaitskell

Total internal reflection fluorescence microscopy (TIRF) has enabled low-background, live-cell friendly imaging of cell surfaces and other thin samples thanks to the shallow penetration of the evanescent light field into the sample. The…

Shortwave-infrared(SWIR) spectral information, ranging from 1 {\mu}m to 2.5{\mu}m, overcomes the limitations of traditional color cameras in acquiring scene information. However, conventional SWIR hyperspectral imaging systems face…

Computer Vision and Pattern Recognition · Computer Science 2024-07-25 Linqiang Li , Jinglei Hao , Yongqiang Zhao , Pan Liu , Haofang Yan , Ziqin Zhang , Seong G. Kong

We devise a new detection technique for mid-infrared multi-heterodyne spectroscopy. As an experimental implementation, mid-infrared light interrogates a gas sample in the 3-$\mu$m region of the fundamental CH, OH, NH stretch in molecules…

Optics · Physics 2020-03-17 Zaijun Chen , Theodor W. Hänsch , Nathalie Picqué

Non-degenerate two-photon absorption (NTA) offers an attractive route for wide-field mid-infrared (MIR) imaging by mapping long wavelength information into the spectral detection windows of mature near-infrared detector technologies.…

Partial occlusion effects are a phenomenon that blurry objects near a camera are semi-transparent, resulting in partial appearance of occluded background. However, it is challenging for existing bokeh rendering methods to simulate realistic…

Computer Vision and Pattern Recognition · Computer Science 2022-07-19 Juewen Peng , Jianming Zhang , Xianrui Luo , Hao Lu , Ke Xian , Zhiguo Cao

Ground-based thermal-infrared observations have a unique scientific potential, but are also extremely challenging due to the need to accurately subtract the high thermal background. Since the established techniques of chopping and nodding…

We present a wide-field homodyne imaging system capable of recovering intensity and phase images of an object from a single camera frame at an illumination intensity significantly below the noise floor of the camera. By interfering a weak…

The resolving ability of widefield fluorescence microscopy is fundamentally limited by out-of-focus background owing to its low axial resolution, particularly for densely labeled biological samples. Although total internal reflection…

Understanding the biophysical and biochemical properties of molecular nanocarriers under physiological conditions and with minimal interference is crucial for advancing nanomedicine, photopharmacology, drug delivery, nanotheranostics and…

Structured illumination microscopy (SIM) enables live cell, super-resolution imaging at high speeds. SIM uses sophisticated optical systems to generate pre-determined excitation light patterns, and reconstruction algorithms to enhance the…

We introduce a new, highly sensitive, and simple heterodyne optical method for imaging individual nonfluorescent nanoclusters and nanocrystals. A 2 order of magnitude improvement of the signal is achieved compared to previous methods. This…

Optics · Physics 2007-05-23 Stéphane Berciaud , Laurent Cognet , Gerhard A Blab , Brahim Lounis

Snapshot spectral imaging is rapidly gaining interest for remote sensing applications. Acquiring spatial and spectral data within one image promotes fast measurement times, and reduces the need for stabilized scanning imaging systems. Many…

Image and Video Processing · Electrical Eng. & Systems 2018-12-05 Rebecca French , Sylvain Gigan , Otto L. Muskens

This paper proposes a non-computational method of counteracting the effect of image degradation introduced by the diffraction phenomenon in lensless microscopy. All the optical images (whether focused by lenses or not) are diffraction…

Optics · Physics 2021-04-08 Sanjeev Kumar , Manjunatha Mahadevappa , Pranab Kumar Dutta

Multispectral imaging (MSI) captures data across multiple spectral bands, offering enhanced informational depth compared to standard RGB imaging and benefiting diverse fields such as agriculture, medical diagnostics, and industrial…

Instrumentation and Detectors · Physics 2025-08-29 Muchen Zhu , Baolei Liu , Yao Wang , Linjun Zhai , Jiaqi Song , Nana Liu , Zhaohua Yang , Lei Ding , Fan Wang

Broadband mid-infrared (mid-IR) spectroscopy applications could greatly benefit from today's well-developed, highly scalable silicon photonics technology; however, this platform lacks broadband transparency due to its reliance on absorptive…

Labelfree nanoscopy encompasses optical imaging with resolution in the 100 nm range using visible wavelengths. Here, we present a labelfree nanoscopy method that combines Fourier ptychography with waveguide microscopy to realize a…

Fourier ptychographic microscopy (FPM) is a powerful computational imaging modality that achieves high space-bandwidth product imaging for biomedical samples. However, its adoption is limited by slow data acquisition due to the need for…

Optics · Physics 2025-09-09 Shi Zhao , Haowen Zhou , Changhuei Yang

We present a compact, noise-resilient reconstructive spectrometer-on-a-chip that achieves high-resolution hyperspectral imaging across an extended near-infrared (NIR) range up to 1100nm. The device integrates monolithically fabricated…

Optics · Physics 2025-08-26 Ahasan Ahamed , Htet Myat , Amita Rawat , Lisa N McPhillips , M Saif Islam