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When a collection of phenotypically diverse organisms compete with each other for limited resources, with competition being strongest amongst the most similar, the population can evolve into tightly localised clusters. This process can be…

Populations and Evolution · Quantitative Biology 2012-05-16 Tim Rogers , Alan J. McKane , Axel G. Rossberg

Deep convolutional neural networks have shown remarkable performance on various computer vision tasks, and yet, they are susceptible to picking up spurious correlations from the training signal. So called `shortcuts' can occur during…

Computer Vision and Pattern Recognition · Computer Science 2022-09-21 Mobarakol Islam , Ben Glocker

Selecting relevant features associated with a given response variable is an important issue in many scientific fields. Quantifying quality and uncertainty of a selection result via false discovery rate (FDR) control has been of recent…

Methodology · Statistics 2020-12-17 Chenguang Dai , Buyu Lin , Xin Xing , Jun S. Liu

We introduce a model of DNA sequence evolution which can account for biases in mutation rates that depend on the identity of the neighboring bases. An analytic solution for this class of non-equilibrium models is developed by adopting…

Biological Physics · Physics 2007-05-23 Peter F. Arndt , Christopher B. Burge , Terence Hwa

Evolution of gene regulation is crucial for our understanding of the phenotypic differences between species, populations and individuals. Sequence-specific binding of transcription factors to the regulatory regions on the DNA is a key…

Populations and Evolution · Quantitative Biology 2015-11-09 Murat Tuğrul , Tiago Paixão , Nicholas H. Barton , Gašper Tkačik

Transcription factors (TFs) exert their regulatory action by binding to DNA with specific sequence preferences. However, different TFs can partially share their binding sequences due to their common evolutionary origin. This `redundancy' of…

Genomics · Quantitative Biology 2018-12-05 Antonio Rosanova , Alberto Colliva , Matteo Osella , Michele Caselle

Selection, the tendency of some traits to become more frequent than others in a population under the influence of some (natural or artificial) agency, is a key component of Darwinian evolution and countless other natural and social…

Populations and Evolution · Quantitative Biology 2017-05-24 Matteo Smerlak , Ahmed Youssef

Density dependence is important in the ecology and evolution of microbial and cancer cells. Typically, we can only measure net growth rates, but the underlying density-dependent mechanisms that give rise to the observed dynamics can…

Populations and Evolution · Quantitative Biology 2025-06-04 Linh Huynh , Jacob G. Scott , Peter J. Thomas

Two major sources of stochasticity in the dynamics of neutral alleles result from resampling of finite populations (genetic drift) and the random genetic background of nearby selected alleles on which the neutral alleles are found (linked…

Populations and Evolution · Quantitative Biology 2013-01-15 Graham Coop , Peter Ralph

Dynamic feature selection (DFS) addresses budget constraints in decision-making by sequentially acquiring features for each instance, making it appealing for resource-limited scenarios. However, existing DFS methods require models…

Machine Learning · Computer Science 2026-02-19 Javier Fumanal-Idocin , Raquel Fernandez-Peralta , Javier Andreu-Perez

Discovering evolutionary traits that are heritable across species on the tree of life (also referred to as a phylogenetic tree) is of great interest to biologists to understand how organisms diversify and evolve. However, the measurement of…

An increasing number of dissident voices claim that the standard neo-Darwinian view of genes as 'leaders' and phenotypes as 'followers' during the process of adaptive evolution should be turned on its head. This idea is older than the…

Populations and Evolution · Quantitative Biology 2015-03-10 Mauro Santos , Eörs Szathmáry , José F. Fontanari

Observed differences in mean phenotypic values across human groups have attracted renewed interest with the rise of large-scale genomic studies and polygenic risk prediction. However, the genetic basis of these differences is far more…

Populations and Evolution · Quantitative Biology 2026-05-25 Nicole Kleman , Meng Lin , Christopher R. Gignoux , Arslan A. Zaidi

Genetic drift is stochastic fluctuations of alleles frequencies in a population due to sampling effects. We consider a model of drift in an equilibrium population, with high mutation rates: few functional mutations per generation. Such…

Populations and Evolution · Quantitative Biology 2017-01-12 Alexey A. Shadrin , Dmitri V. Parkhomchuk

When biological populations expand into new territory, the evolutionary outcomes can be strongly influenced by genetic drift, the random fluctuations in allele frequencies. Meanwhile, spatial variability in the environment can also…

Populations and Evolution · Quantitative Biology 2024-06-27 Jimmy Gonzalez Nuñez , Jayson Paulose , Wolfram Möbius , Daniel A. Beller

Embedding learning has found widespread applications in recommendation systems and natural language modeling, among other domains. To learn quality embeddings efficiently, adaptive learning rate algorithms have demonstrated superior…

Machine Learning · Computer Science 2021-11-24 Yan Li , Dhruv Choudhary , Xiaohan Wei , Baichuan Yuan , Bhargav Bhushanam , Tuo Zhao , Guanghui Lan

While Neutral Theory famously describes the number of discrete genetic differences in populations, we consider the number of genetic backgrounds under which such differences are observed - setting limits to the generalizability of their…

Populations and Evolution · Quantitative Biology 2023-03-21 Andre F. Ribeiro

Predicting the adaptation of populations to a changing environment is crucial to assess the impact of human activities on biodiversity. Many theoretical studies have tackled this issue by modeling the evolution of quantitative traits…

Analysis of PDEs · Mathematics 2022-06-28 Jimmy Garnier , O Cotto , T Bourgeron , E Bouin , T Lepoutre , O Ronce , V Calvez

The statistical regularities in language corpora encode well-known social biases into word embeddings. Here, we focus on gender to provide a comprehensive analysis of group-based biases in widely-used static English word embeddings trained…

Computers and Society · Computer Science 2022-06-08 Aylin Caliskan , Pimparkar Parth Ajay , Tessa Charlesworth , Robert Wolfe , Mahzarin R. Banaji

Stochastic models of evolution (Markov random fields on trivalent trees) generally assume that different characters (different runs of the stochastic process) are independent and identically distributed. In this paper we take the first…

Populations and Evolution · Quantitative Biology 2014-10-28 Deeparnab Chakrabarty , Sampath Kannan , Kevin Tian