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This paper introduces a new optimal control model to describe and control the dynamics of infectious diseases. In the present model, the average time of isolation (i.e. hospitalization) of infectious population is the main time-dependent…

Optimization and Control · Mathematics 2015-05-06 Robin J. Evans , Musa Mammadov

The aim of this paper is to provide a rigorous mathematical analysis of an optimal control problem with SIR dynamics. The main feature of our study is the presence of state constraints (related to intensive care units ICU capacity) and…

Optimization and Control · Mathematics 2021-08-25 Florin Avram , Lorenzo Freddi , Dan Goreac

Susceptibility governs the dynamics of contagion. The classical SIR model is one of the simplest compartmental models of contagion spread, assuming a single shared susceptibility level. However, variation in susceptibility over a population…

Populations and Evolution · Quantitative Biology 2020-09-22 Christopher Rose , Andrew J. Medford , C. Franklin Goldsmith , Tejs Vegge , Joshua Weitz , Andrew A. Peterson

We propose a stochastic SIR model, specified as a system of stochastic differential equations, to analyse the data of the Italian COVID-19 epidemic, taking also into account the under-detection of infected and recovered individuals in the…

Populations and Evolution · Quantitative Biology 2021-02-22 Sara Pasquali , Antonio Pievatolo , Antonella Bodini , Fabrizio Ruggeri

In this work we analyze mathematically the consequences and effectiveness of strategies to control an epidemic in the framework of classical SEIR models with multiple parallel infectious stages. We define the mathematical concept of a…

Dynamical Systems · Mathematics 2023-08-17 Annibal Figueiredo , Tarcısio Marciano da Rocha Filho

Covid-19 is one of the most dreaded pandemics/epidemics in the world threatening the human population. The dynamics of this pandemic is quite complicated and prediction of pandemic states often fails. In this work, we study and correlate…

Populations and Evolution · Quantitative Biology 2021-10-06 Jyoti Bhadana , R. K. Brojen Singh

The worldwide spread of COVID-19 has called for fast advancement of new modelling strategies to estimate its unprecedented spread. Here, we introduce a model based on the fundamental SIR equations with a stochastic disorder by a random…

Physics and Society · Physics 2020-04-28 Suman Dutta

Multiple viruses are widely studied because of their negative effect on the health of host as well as on whole population. The dynamics of coinfection is important in this case. We formulated a SIR model that describes the coinfection of…

Dynamical Systems · Mathematics 2019-05-14 Samia Ghersheen , Vladimir Kozlov , Vladimir G. Tkachev , Uno Wennergren

In this article, we model and study the spread of COVID-19 in Germany, Japan, India and highly impacted states in India, i.e., in Delhi, Maharashtra, West Bengal, Kerala and Karnataka. We consider recorded data published in Worldometers and…

Physics and Society · Physics 2022-03-15 Ian Cooper , Argha Mondal , Chris G. Antonopoulos , Arindam Mishra

The last decade saw the advent of increasingly realistic epidemic models that leverage on the availability of highly detailed census and human mobility data. Data-driven models aim at a granularity down to the level of households or single…

Populations and Evolution · Quantitative Biology 2011-08-10 Nicola Perra , Duygu Balcan , Bruno Gonçalves , Alessandro Vespignani

We propose a dynamical model for describing the spread of epidemics. This model is an extension of the SIQR (susceptible-infected-quarantined-recovered) and SIRP (susceptible-infected-recovered-pathogen) models used earlier to describe…

Physics and Society · Physics 2022-12-08 S. P. Lukyanets , I. S. Gandzha , O. V. Kliushnichenko

While many epidemiological models have being proposed to understand and handle COVID-19, too little has been invested to understand how the virus replicates in the human body and potential antiviral can be used to control the replication…

This article considers the optimal control of the SIR model with both transmission and treatment uncertainty. It follows the model presented in Gatto and Schellhorn (2021). We make four significant improvements on the latter paper. First,…

Optimization and Control · Mathematics 2021-05-20 Yujia Ding , Henry Schellhorn

This paper analyses the optimal control of infectious disease propagation using a classic susceptible-infected-recovered (SIR) model characterised by permanent immunity and the absence of available vaccines. The control is performed over a…

Optimization and Control · Mathematics 2024-06-12 Rocío Balderrama , Mariana Inés Prieto , Constanza Sánchez de la Vega , Federico Vazquez

Stochastic models are widely used to investigate the spread of epidemics in a complex environment. This paper extends a deterministic SAIRS epidemic model to a stochastic case with limited patient capacity and exposure. We first study the…

Probability · Mathematics 2024-05-20 Xiaohui Zhang , Zhiming Li , Shenglong Chen , Jikai Yang

We consider the problem of controlling an SIR-model epidemic by temporarily reducing the rate of contact within a population. The control takes the form of a multiplicative reduction in the contact rate of infectious individuals. The…

Optimization and Control · Mathematics 2021-06-29 David I. Ketcheson

This paper is concerned with the well-posedness and optimal control problem of a reaction-diffusion system for an epidemic Susceptible-Infected-Recovered-Susceptible (SIRS) mathematical model in which the dynamics develops in a spatially…

Optimization and Control · Mathematics 2023-04-24 Pierluigi Colli , Gianni Gilardi , Gabriela Marinoschi , Elisabetta Rocca

For preventing the spread of epidemics such as the coronavirus disease COVID-19, social distancing and the isolation of infected persons are crucial. However, existing reaction-diffusion equations for epidemic spreading are incapable of…

Populations and Evolution · Quantitative Biology 2020-11-18 Michael te Vrugt , Jens Bickmann , Raphael Wittkowski

This paper presents a detailed mathematical investigation into the dynamics of COVID-19 infections through extended Susceptible-Infected-Recovered (SIR) and Susceptible-Exposed-Infected-Recovered (SEIR) epidemiological models. By…

Populations and Evolution · Quantitative Biology 2025-05-21 Caleb Traxler , Minh Ton , Nameer Ahmed , Sasha Prostota , Annie Cheng

Different countries -- and sometimes different regions within the same countries -- have adopted different strategies in trying to contain the ongoing COVID-19 epidemic; these mix in variable parts social confinement, early detection and…

Populations and Evolution · Quantitative Biology 2020-07-17 Giuseppe Gaeta