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This paper presents a highly efficient method to obtain high-resolution, near-optimal 3D topologies optimized for minimum compliance on a standard PC. Using an implicit geometry description we derive a single-scale interpretation of optimal…

Computational Engineering, Finance, and Science · Computer Science 2020-04-22 Jeroen Groen , Florian Stutz , Niels Aage , J. Andreas Bærentzen , Ole Sigmund

Molecule generation is a very important practical problem, with uses in drug discovery and material design, and AI methods promise to provide useful solutions. However, existing methods for molecule generation focus either on 2D graph…

Machine Learning · Computer Science 2024-02-07 Chenqing Hua , Sitao Luan , Minkai Xu , Rex Ying , Jie Fu , Stefano Ermon , Doina Precup

Accurate segmentation of tubular structures in medical images, such as vessels and airway trees, is crucial for computer-aided diagnosis, radiotherapy, and surgical planning. However, significant challenges exist in algorithm design when…

Image and Video Processing · Electrical Eng. & Systems 2025-04-11 Yi Huang , Ke Zhang , Wei Liu , Yuanyuan Wang , Vishal M. Patel , Le Lu , Xu Han , Dakai Jin , Ke Yan

Optimization and uncertainty quantification have been playing an increasingly important role in computational hemodynamics. However, existing methods based on principled modeling and classic numerical techniques have faced significant…

Medical Physics · Physics 2022-09-07 Pan Du , Xiaozhi Zhu , Jian-Xun Wang

Both discrete and continuum models have been widely used to study rapid granular flow, discrete model is accurate but computationally expensive, whereas continuum model is computationally efficient but its accuracy is doubtful in many…

Fluid Dynamics · Physics 2015-12-24 Xizhong Chen , Junwu Wang , Jinghai Li

This paper sums up some recent validations of an immersed boundary method for compressible flow simulations. It has been already shown that this method is able to provide accurate results without meshing effort around more or less complex…

Fluid Dynamics · Physics 2019-02-19 Thomas Renaud , Christophe Benoit , Stephanie Péron , Ivan Mary , Nicolas Alferez

This study presents a simplified FEM modeling approach suitable for large structures made of corrugated boards, such as customized packages, based on a homogenization method, which is combined with correction factors for internal…

Applied Physics · Physics 2025-08-05 Ricardo Fitas , Heinz Joachim Schaffrath , Samuel Schabel

We propose an efficient numerical strategy for simulating fluid flow through porous media with highly oscillatory characteristics. Specifically, we consider non-linear diffusion models. This scheme is based on the classical homogenization…

Numerical Analysis · Mathematics 2020-02-04 Manuela Bastidas , Carina Bringedal , Sorin Pop , Florin Radu

We generalize to three dimensions (3D) a recently developed improved multi-component pseudopotential lattice Boltzmann method and analyze its applicability to simulate flows through realistic porous media. The model is validated and…

Fluid Dynamics · Physics 2022-10-04 M. Sedahmed , R. C. V. Coelho , N. A. M. Araújo , E. M. Wahba , H. A. Warda

Mathematical modeling at the level of the full cardiovascular system requires the numerical approximation of solutions to a one-dimensional nonlinear hyperbolic system describing flow in a single vessel. This model is often simulated by…

Computational Physics · Physics 2015-04-22 Sebastian Acosta , Charles Puelz , Beatrice Riviere , Daniel J. Penny , Craig G. Rusin

The rapid advances in 3D scanning and acquisition techniques have given rise to the explosive increase of volumetric digital models in recent years. This dissertation systematically trailblazes a novel volumetric modeling framework to…

Graphics · Computer Science 2013-08-06 Bo Li

Generating high-quality videos that synthesize desired realistic content is a challenging task due to their intricate high-dimensionality and complexity of videos. Several recent diffusion-based methods have shown comparable performance by…

Computer Vision and Pattern Recognition · Computer Science 2024-04-05 Kihong Kim , Haneol Lee , Jihye Park , Seyeon Kim , Kwanghee Lee , Seungryong Kim , Jaejun Yoo

In this paper, we investigate the tumor instability by employing both analytical and numerical techniques to validate previous results and extend the analytical findings presented in a prior study by Feng et al 2023. Building upon the…

Analysis of PDEs · Mathematics 2024-01-11 Jian-Guo Liu , Thomas Witelski , Xiaoqian Xu , Jiaqi Zhang

Currently, most of the basic mechanisms governing tumor-immune system interactions, in combination with modulations of tumor-associated vasculature, are far from being completely understood. Here, we propose a mathematical model of…

Tissues and Organs · Quantitative Biology 2015-10-07 H. Hatzikirou , J. C. L. Alfonso , S. Muhle , C. Stern , S. Weiss , M. Meyer-Hermann

We present a methodology for simulating three-dimensional flow of incompressible viscoplastic fluids modelled by generalised Newtonian rheological equations. It is implemented in a highly efficient framework for massively parallelisable…

Fluid Dynamics · Physics 2019-09-17 Knut Sverdrup , Ann Almgren , Nikolaos Nikiforakis

One of the more promising recent approaches to turbulence modelling is the Variational Multiscale Large Eddy Simulation (VMS LES) method proposed by Hughes et al. [Comp. Visual. Sci., vol. 3, pp. 47-59, 2000]. This method avoids several…

Computational Physics · Physics 2007-05-23 Thor Gjesdal , Carl Erik Wasberg , Bjorn Anders Pettersson Reif , Oyvind Andreassen

Quantitative information on tumor heterogeneity and cell load could assist in designing effective and refined personalized treatment strategies. It was recently shown by us that such information can be inferred from the diffusion parameter…

Image and Video Processing · Electrical Eng. & Systems 2021-03-11 Yi Yin , Kai Breuhahn , Hans-Ulrich Kauczor , Oliver Sedlaczek , Irene E. Vignon-Clementel , Dirk Drasdo

Despite the remarkable generative capabilities of diffusion models, their integration into safety-critical or scientifically rigorous applications remains hindered by the need to ensure compliance with stringent physical, structural, and…

Machine Learning · Computer Science 2025-06-03 Jacob K. Christopher , Michael Cardei , Jinhao Liang , Ferdinando Fioretto

Automated blood vessel segmentation is vital for biomedical imaging, as vessel changes indicate many pathologies. Still, precise segmentation is difficult due to the complexity of vascular structures, anatomical variations across patients,…

This paper introduces a method for estimating the shape and location of an embedded tumor. The approach utilizes shape optimization techniques, applying the coupled complex boundary method. By rewriting the problem -- characterized by a…

Numerical Analysis · Mathematics 2025-05-30 Julius Fergy Tiongson Rabago