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Large Language Models (LLMs) with their strong task-handling capabilities have shown remarkable advancements across a spectrum of fields, moving beyond natural language understanding. However, their proficiency within the chemistry domain…

Computer Vision and Pattern Recognition · Computer Science 2026-02-02 Khiem Le , Zhichun Guo , Kaiwen Dong , Xiaobao Huang , Bozhao Nan , Roshni Iyer , Xiangliang Zhang , Olaf Wiest , Wei Wang , Ting Hua , Nitesh V. Chawla

Artificial Intelligence (AI) is revolutionizing scientific research, yet its growing integration into laboratory environments presents critical safety challenges. Large language models (LLMs) and vision language models (VLMs) now assist in…

The response time of a biosensor is a crucial metric in safety-critical applications such as medical diagnostics where an earlier diagnosis can markedly improve patient outcomes. However, the speed at which a biosensor reaches a final…

Machine Learning · Computer Science 2024-09-30 Simon J. Ward , Muhamed Baljevic , Sharon M. Weiss

The rapid adoption of LLMs in both research and industry highlights the challenges of deploying them safely and reveals a gap in the systematic evaluation of toxicity benchmarks. As organizations increasingly rely on these benchmarks to…

Artificial Intelligence · Computer Science 2026-05-12 Regina Gugg , Selina Niederländer , Andreas Stöckl , Martin Flechl

The United States is experiencing an opioid epidemic, and there were more than 10 million opioid misusers aged 12 or older each year. Identifying patients at high risk of Opioid Use Disorder (OUD) can help to make early clinical…

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

In recent decades, financial quantification has emerged and matured rapidly. For financial institutions such as funds, investment institutions are increasingly dissatisfied with the situation of passively constructing investment portfolios…

Computational Engineering, Finance, and Science · Computer Science 2024-04-03 Qishuo Cheng

Using generative deep learning models and reinforcement learning together can effectively generate new molecules with desired properties. By employing a multi-objective scoring function, thousands of high-scoring molecules can be generated,…

In the intersection of molecular science and deep learning, tasks like virtual screening have driven the need for a high-throughput molecular representation generator on large chemical databases. However, as SMILES strings are the most…

Computational Engineering, Finance, and Science · Computer Science 2021-12-28 Wenhao Zhu , Ziyao Li , Lingsheng Cai , Guojie Song

Representing molecular structures effectively in chemistry remains a challenging task. Language models and graph-based models are extensively utilized within this domain, consistently achieving state-of-the-art results across an array of…

Machine Learning · Computer Science 2025-05-27 Nikolai Rekut , Alexey Orlov , Klea Ziu , Elizaveta Starykh , Martin Takac , Aleksandr Beznosikov

Toxic content detection is crucial for online services to remove inappropriate content that violates community standards. To automate the detection process, prior works have proposed varieties of machine learning (ML) approaches to train…

Computation and Language · Computer Science 2023-12-14 Jiang Zhang , Qiong Wu , Yiming Xu , Cheng Cao , Zheng Du , Konstantinos Psounis

Physicians considering clinical trials for their patients are met with the laborious process of checking many text based eligibility criteria. Large Language Models (LLMs) have shown to perform well for clinical information extraction and…

Machine Learning · Computer Science 2023-06-30 Danny M. den Hamer , Perry Schoor , Tobias B. Polak , Daniel Kapitan

The potential number of drug like small molecules is estimated to be between 10^23 and 10^60 while current databases of known compounds are orders of magnitude smaller with approximately 10^8 compounds. This discrepancy has led to an…

Machine Learning · Computer Science 2017-05-18 Esben Jannik Bjerrum , Richard Threlfall

Identification of high affinity drug-target interactions is a major research question in drug discovery. Proteins are generally represented by their structures or sequences. However, structures are available only for a small subset of…

Machine Learning · Computer Science 2020-12-22 Rıza Özçelik , Hakime Öztürk , Arzucan Özgür , Elif Ozkirimli

Behavioral model diagrams, e.g., sequence diagrams, are an essential form of documentation that are typically designed by system engineers from requirements documentation, either fully manually or assisted by design tools. With the growing…

Software Engineering · Computer Science 2025-09-03 Khaled Ahmed , Jialing Song , Boqi Chen , Ou Wei , Bingzhou Zheng

Retrosynthesis, the process of breaking down a target molecule into simpler precursors through a series of valid reactions, stands at the core of organic chemistry and drug development. Although recent machine learning (ML) research has…

Artificial Intelligence · Computer Science 2026-05-12 Haorui Wang , Jeff Guo , Lingkai Kong , Rampi Ramprasad , Philippe Schwaller , Yuanqi Du , Chao Zhang

Recent work has demonstrated robust mechanisms by which attacks can be orchestrated on machine learning models. In contrast to adversarial examples, backdoor or trojan attacks embed surgically modified samples with targeted labels in the…

Cryptography and Security · Computer Science 2019-03-19 Zhaoyuan Yang , Naresh Iyer , Johan Reimann , Nurali Virani

One of the most important challenges in the field of software code audit is the presence of vulnerabilities in software source code. These flaws are highly likely ex-ploited and lead to system compromise, data leakage, or denial of…

Machine Learning · Computer Science 2023-03-15 Mst Shapna Akter , Hossain Shahriar , Zakirul Alam Bhuiya

Suicide is a pressing global issue, demanding urgent and effective preventive interventions. Among the various strategies in place, psychological support hotlines had proved as a potent intervention method. Approximately two million people…

Computation and Language · Computer Science 2024-09-11 Yining Chen , Jianqiang Li , Changwei Song , Qing Zhao , Yongsheng Tong , Guanghui Fu

Game semantics is a powerful method of semantic analysis for programming languages. It gives mathematically accurate models ("fully abstract") for a wide variety of programming languages. Game semantic models are combinatorial…

Programming Languages · Computer Science 2017-12-04 Dan R. Ghica , Khulood Alyahya