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In medical image segmentation across multiple modalities (e.g., MRI, CT, etc.) and heterogeneous data sources (e.g., different hospitals and devices), Domain Generalization (DG) remains a critical challenge in AI-driven healthcare. This…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Yucheng Song , Chenxi Li , Haokang Ding , Zhining Liao , Zhifang Liao

For histopathological tumor assessment, the count of mitotic figures per area is an important part of prognostication. Algorithmic approaches - such as for mitotic figure identification - have significantly improved in recent times,…

Computer Vision and Pattern Recognition · Computer Science 2020-02-20 Marc Aubreville , Christof A. Bertram , Samir Jabari , Christian Marzahl , Robert Klopfleisch , Andreas Maier

The different stain styles of cytopathological images have a negative effect on the generalization ability of automated image analysis algorithms. This article proposes a new framework that normalizes the stain style for cytopathological…

Image and Video Processing · Electrical Eng. & Systems 2019-09-12 Xihao Chen , Jingya Yu , Li Chen , Shaoqun Zeng , Xiuli Liu , Shenghua Cheng

The density of mitotic figures within tumor tissue is known to be highly correlated with tumor proliferation and thus is an important marker in tumor grading. Recognition of mitotic figures by pathologists is known to be subject to a strong…

Self-supervised vision models have achieved notable success in digital pathology. However, their domain-agnostic transformer architectures are not originally designed to account for fundamental biological elements of histopathology images,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Sevda Öğüt , Cédric Vincent-Cuaz , Natalia Dubljevic , Carlos Hurtado , Vaishnavi Subramanian , Pascal Frossard , Dorina Thanou

Digitization techniques for biomedical images yield different visual patterns in radiological exams. These differences may hamper the use of data-driven approaches for inference over these images, such as Deep Neural Networks. Another…

Computer Vision and Pattern Recognition · Computer Science 2019-12-10 Hugo Oliveira , Edemir Ferreira , Jefersson A. dos Santos

Domain shift refers to the well known problem that a model trained in one source domain performs poorly when applied to a target domain with different statistics. {Domain Generalization} (DG) techniques attempt to alleviate this issue by…

Machine Learning · Computer Science 2017-10-11 Da Li , Yongxin Yang , Yi-Zhe Song , Timothy M. Hospedales

Domain generalization aims to develop models that are robust to distribution shifts. Existing methods focus on learning invariance across domains to enhance model robustness, and data augmentation has been widely used to learn invariant…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Yingnan Liu , Yingtian Zou , Rui Qiao , Fusheng Liu , Mong Li Lee , Wynne Hsu

While machine learning is currently transforming the field of histopathology, the domain lacks a comprehensive evaluation of state-of-the-art models based on essential but complementary quality requirements beyond a mere classification…

Image and Video Processing · Electrical Eng. & Systems 2023-05-11 Maximilian Springenberg , Annika Frommholz , Markus Wenzel , Eva Weicken , Jackie Ma , Nils Strodthoff

Despite that the performance of image-to-image translation has been significantly improved by recent progress in generative models, current methods still suffer from severe degradation in training stability and sample quality when applied…

Computer Vision and Pattern Recognition · Computer Science 2019-04-16 Jie Cao , Huaibo Huang , Yi Li , Jingtuo Liu , Ran He , Zhenan Sun

The lack of out-of-domain generalization is a critical weakness of deep networks for semantic segmentation. Previous studies relied on the assumption of a static model, i. e., once the training process is complete, model parameters remain…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Sherwin Bahmani , Oliver Hahn , Eduard Zamfir , Nikita Araslanov , Daniel Cremers , Stefan Roth

Deep learning-based medical image segmentation faces significant challenges arising from limited labeled data and domain shifts. While prior approaches have primarily addressed these issues independently, their simultaneous occurrence is…

Computer Vision and Pattern Recognition · Computer Science 2025-06-30 Zanting Ye , Ke Wang , Wenbing Lv , Qianjin Feng , Lijun Lu

Deep learning (DL) applied to breast tissue segmentation in magnetic resonance imaging (MRI) has received increased attention in the last decade, however, the domain shift which arises from different vendors, acquisition protocols, and…

We focus on the problem of training convolutional neural networks on gigapixel histopathology images to predict image-level targets. For this purpose, we extend Neural Image Compression (NIC), an image compression framework that reduces the…

Image and Video Processing · Electrical Eng. & Systems 2020-04-16 David Tellez , Diederik Hoppener , Cornelis Verhoef , Dirk Grunhagen , Pieter Nierop , Michal Drozdzal , Jeroen van der Laak , Francesco Ciompi

Supervised semantic segmentation normally assumes the test data being in a similar data domain as the training data. However, in practice, the domain mismatch between the training and unseen data could lead to a significant performance…

Computer Vision and Pattern Recognition · Computer Science 2019-09-26 Xianxu Hou , Jingxin Liu , Bolei Xu , Bozhi Liu , Xin Chen , Mohammad Ilyas , Ian Ellis , Jon Garibaldi , Guoping Qiu

Visual microscopic study of diseased tissue by pathologists has been the cornerstone for cancer diagnosis and prognostication for more than a century. Recently, deep learning methods have made significant advances in the analysis and…

Image and Video Processing · Electrical Eng. & Systems 2022-09-30 Puria Azadi Moghadam , Sanne Van Dalen , Karina C. Martin , Jochen Lennerz , Stephen Yip , Hossein Farahani , Ali Bashashati

We propose an approach to domain adaptation for semantic segmentation that is both practical and highly accurate. In contrast to previous work, we abandon the use of computationally involved adversarial objectives, network ensembles and…

Computer Vision and Pattern Recognition · Computer Science 2021-05-04 Nikita Araslanov , Stefan Roth

We tackle the challenging problem of single-source domain generalization (DG) for medical image segmentation, where we train a network on one domain (e.g., CT) and directly apply it to a different domain (e.g., MR) without adapting the…

Computer Vision and Pattern Recognition · Computer Science 2026-04-29 Franz Thaler , Martin Urschler , Mateusz Kozinski , Matthias AF Gsell , Gernot Plank , Darko Stern

Motivation: Medical image analysis involves tasks to assist physicians in qualitative and quantitative analysis of lesions or anatomical structures, significantly improving the accuracy and reliability of diagnosis and prognosis.…

Computer Vision and Pattern Recognition · Computer Science 2022-06-30 Mingzhe Hu , Jiahan Zhang , Luke Matkovic , Tian Liu , Xiaofeng Yang

Recognition of mitotic figures in histologic tumor specimens is highly relevant to patient outcome assessment. This task is challenging for algorithms and human experts alike, with deterioration of algorithmic performance under shifts in…