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Image normalization is a building block in medical image analysis. Conventional approaches are customarily utilized on a per-dataset basis. This strategy, however, prevents the current normalization algorithms from fully exploiting the…

Machine Learning · Computer Science 2020-10-06 Pierre-Luc Delisle , Benoit Anctil-Robitaille , Christian Desrosiers , Herve Lombaert

Histopathology image analysis plays a critical role in cancer diagnosis and treatment. To automatically segment the cancerous regions, fully supervised segmentation algorithms require labor-intensive and time-consuming labeling at the pixel…

Image and Video Processing · Electrical Eng. & Systems 2019-08-29 Gang Xu , Zhigang Song , Zhuo Sun , Calvin Ku , Zhe Yang , Cancheng Liu , Shuhao Wang , Jianpeng Ma , Wei Xu

Histopathology images; microscopy images of stained tissue biopsies contain fundamental prognostic information that forms the foundation of pathological analysis and diagnostic medicine. However, diagnostics from histopathology images…

Computer Vision and Pattern Recognition · Computer Science 2019-10-30 Aïcha BenTaieb , Ghassan Hamarneh

Deep learning has been extensively used in various fields, such as phase imaging, 3D imaging reconstruction, phase unwrapping, and laser speckle reduction, particularly for complex problems that lack analytic models. Its data-driven nature…

Machine Learning · Computer Science 2024-10-16 Xuyu Zhang , Haofan Huang , Dawei Zhang , Songlin Zhuang , Shensheng Han , Puxiang Lai , Honglin Liu

Breast cancer is the most common cancer type in women worldwide. Early detection and appropriate treatment can significantly reduce its impact. While histopathology examinations play a vital role in rapid and accurate diagnosis, they often…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Nematollah Saeidi , Hossein Karshenas , Bijan Shoushtarian , Sepideh Hatamikia , Ramona Woitek , Amirreza Mahbod

Domain adaptation (DA) is a quickly expanding area in machine learning that involves adjusting a model trained in one domain to perform well in another domain. While there have been notable progressions, the fundamental concept of numerous…

Computer Vision and Pattern Recognition · Computer Science 2026-02-11 Yihang Wu , Ahmad Chaddad

It is commonly recognized that color variations caused by differences in stains is a critical issue for histopathology image analysis. Existing methods adopt color matching, stain separation, stain transfer or the combination of them to…

Image and Video Processing · Electrical Eng. & Systems 2022-08-09 Hai-Li Ye , Da-Han Wang

Domain generalisation in computational histopathology is challenging because the images are substantially affected by differences among hospitals due to factors like fixation and staining of tissue and imaging equipment. We hypothesise that…

Image and Video Processing · Electrical Eng. & Systems 2024-11-15 Dhananjay Tomar , Alexander Binder , Andreas Kleppe

Histopathology image analysis is the golden standard of clinical diagnosis for Cancers. In doctors daily routine and computer-aided diagnosis, the Whole Slide Image (WSI) of histopathology tissue is used for analysis. Because of the…

Computer Vision and Pattern Recognition · Computer Science 2023-11-23 Honglin Li , Yunlong Zhang , Chenglu Zhu , Jiatong Cai , Sunyi Zheng , Lin Yang

Despite domain generalization (DG) has significantly addressed the performance degradation of pre-trained models caused by domain shifts, it often falls short in real-world deployment. Test-time adaptation (TTA), which adjusts a learned…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Xingguo Lv , Xingbo Dong , Liwen Wang , Jiewen Yang , Lei Zhao , Bin Pu , Zhe Jin , Xuejun Li

Automatic and accurate Gleason grading of histopathology tissue slides is crucial for prostate cancer diagnosis, treatment, and prognosis. Usually, histopathology tissue slides from different institutions show heterogeneous appearances…

Computer Vision and Pattern Recognition · Computer Science 2018-06-08 Jian Ren , Ilker Hacihaliloglu , Eric A. Singer , David J. Foran , Xin Qi

Mammography-based screening has helped reduce the breast cancer mortality rate, but has also been associated with potential harms due to low specificity, leading to unnecessary exams or procedures, and low sensitivity. Digital breast…

Computer Vision and Pattern Recognition · Computer Science 2020-01-24 Sadanand Singh , Thomas Paul Matthews , Meet Shah , Brent Mombourquette , Trevor Tsue , Aaron Long , Ranya Almohsen , Stefano Pedemonte , Jason Su

Supervised deep learning relies on the assumption that enough training data is available, which presents a problem for its application to several fields, like medical imaging. On the example of a binary image classification task (breast…

Computer Vision and Pattern Recognition · Computer Science 2019-02-22 Lukas Jendele , Ondrej Skopek , Anton S. Becker , Ender Konukoglu

Fine-grained and instance-level recognition methods are commonly trained and evaluated on specific domains, in a model per domain scenario. Such an approach, however, is impractical in real large-scale applications. In this work, we address…

Data augmentation has proved extremely useful by increasing training data variance to alleviate overfitting and improve deep neural networks' generalization performance. In medical image analysis, a well-designed augmentation policy usually…

Computer Vision and Pattern Recognition · Computer Science 2021-03-31 Yunhe Gao , Zhiqiang Tang , Mu Zhou , Dimitris Metaxas

With the increasing utilization of deep learning in outdoor settings, its robustness needs to be enhanced to preserve accuracy in the face of distribution shifts, such as compression artifacts. Data augmentation is a widely used technique…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Shohei Enomoto , Monikka Roslianna Busto , Takeharu Eda

Meta-learning has recently been an emerging data-efficient learning technique for various medical imaging operations and has helped advance contemporary deep learning models. Furthermore, meta-learning enhances the knowledge generalization…

Image and Video Processing · Electrical Eng. & Systems 2023-07-14 Sriprabha Ramanarayanan , Arun Palla , Keerthi Ram , Mohanasankar Sivaprakasam

We propose a segmentation framework that uses deep neural networks and introduce two innovations. First, we describe a biophysics-based domain adaptation method. Second, we propose an automatic method to segment white and gray matter, and…

Computer Vision and Pattern Recognition · Computer Science 2018-10-16 Amir Gholami , Shashank Subramanian , Varun Shenoy , Naveen Himthani , Xiangyu Yue , Sicheng Zhao , Peter Jin , George Biros , Kurt Keutzer

Widely used traditional supervised deep learning methods require a large number of training samples but often fail to generalize on unseen datasets. Therefore, a more general application of any trained model is quite limited for medical…

Computer Vision and Pattern Recognition · Computer Science 2022-02-01 Rabindra Khadga , Debesh Jha , Steven Hicks , Vajira Thambawita , Michael A. Riegler , Sharib Ali , Pål Halvorsen

Foundation models have transformed vision and language by learning general-purpose representations from large-scale unlabeled data, yet 3D medical imaging lacks analogous approaches. Existing self-supervised methods rely on low-level…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Yunhe Gao , Yabin Zhang , Chong Wang , Jiaming Liu , Maya Varma , Jean-Benoit Delbrouck , Akshay Chaudhari , Curtis Langlotz