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Best match graphs (BMGs) are vertex-colored digraphs that naturally arise in mathematical phylogenetics to formalize the notion of evolutionary closest genes w.r.t. an a priori unknown phylogenetic tree. BMGs are explained by unique least…

Data Structures and Algorithms · Computer Science 2021-03-12 David Schaller , Manuela Geiß , Marc Hellmuth , Peter F. Stadler

Best match graphs (BMG) are a key intermediate in graph-based orthology detection and contain a large amount of information on the gene tree. We provide a near-cubic algorithm to determine whether a BMG is binary-explainable, i.e., whether…

Data Structures and Algorithms · Computer Science 2021-03-09 David Schaller , Manuela Geiß , Marc Hellmuth , Peter F. Stadler

Quasi-best match graphs (qBMGs) are a hereditary class of directed, properly vertex-colored graphs. They arise naturally in mathematical phylogenetics as a generalization of best match graphs, which formalize the notion of evolutionary…

Combinatorics · Mathematics 2023-01-24 Annachiara Korchmaros , David Schaller , Marc Hellmuth , Peter F. Stadler

Reciprocal best matches play an important role in numerous applications in computational biology, in particular as the basis of many widely used tools for orthology assessment. Nevertheless, very little is known about their mathematical…

Populations and Evolution · Quantitative Biology 2019-08-30 Manuela Geiß , Peter F. Stadler , Marc Hellmuth

Best match graphs (BMGs) are vertex-colored directed graphs that were introduced to model the relationships of genes (vertices) from different species (colors) given an underlying evolutionary tree that is assumed to be unknown. In…

Computational Complexity · Computer Science 2020-12-04 David Schaller , Peter F. Stadler , Marc Hellmuth

Recent investigations in computational biology focus on a family of 2-colored digraphs, called 2-colored best match graphs, which naturally arise from rooted phylogenetic trees. Actually the defining properties of such graphs are…

Combinatorics · Mathematics 2020-06-09 Annachiara Korchmaros

Bipartite best match graphs (BMG) and their generalizations arise in mathematical phylogenetics as combinatorial models describing evolutionary relationships among related genes in a pair of species. In this work, we characterize the class…

Combinatorics · Mathematics 2025-11-06 Annachiara Korchmaros , Guillaume E. Scholz , Peter F. Stadler

Reciprocal best match graphs (RBMGs) are vertex colored graphs whose vertices represent genes and the colors the species where the genes reside. Edges identify pairs of genes that are most closely related with respect to an underlying…

Computational Complexity · Computer Science 2019-07-23 Marc Hellmuth , Manuela Geiß , Peter F. Stadler

Best match graphs (BMGs) are a class of colored digraphs that naturally appear in mathematical phylogenetics and can be approximated with the help of similarity measures between gene sequences, albeit not without errors. The corresponding…

Combinatorics · Mathematics 2021-03-15 David Schaller , Manuela Geiß , Marc Hellmuth , Peter F. Stadler

Recent investigations in computational biology have focused on a family of 2-colored digraphs, called 2-colored best match graphs, which naturally arise from rooted phylogenetic trees. Actually the defining properties of such graphs are…

Combinatorics · Mathematics 2020-12-01 Annachiara Korchmaros

THIS IS A CORRECTED VERSION INCLUDING AN APPENDED CORRIGENDUM. Best match graphs arise naturally as the first processing intermediate in algorithms for orthology detection. Let $T$ be a phylogenetic (gene) tree $T$ and $\sigma$ an…

2-colored quasi best match graphs (2-qBMGs) are directed graphs that arose in phylogenetics. Investigations of 2-qBMGs have mostly focused on computational issues. However, 2-qBMGs also have relevant properties for structural graph theory;…

Combinatorics · Mathematics 2025-02-27 Annachiara Korchmaros

A wide variety of problems in computational biology, most notably the assessment of orthology, are solved with the help of reciprocal best matches. Using an evolutionary definition of best matches that captures the intuition behind the…

2-quasi best match graphs (2-qBMGs) are directed graphs that capture a notion of close relatedness in phylogenetics. Here, we investigate the undirected underlying graph of a 2-qBMG (un-2qBMG) and show that they contain neither a path $P_l$…

Combinatorics · Mathematics 2025-12-08 Annachiara Korchmaros , Peter F. Stadler

Tree representations of (sets of) symmetric binary relations, or equivalently edge-colored undirected graphs, are of central interest, e.g.\ in phylogenomics. In this context symbolic ultrametrics play a crucial role. Symbolic ultrametrics…

Discrete Mathematics · Computer Science 2015-09-18 Marc Hellmuth , Nicolas Wieseke

In phylogenetics, a central problem is to infer the evolutionary relationships between a set of species $X$; these relationships are often depicted via a phylogenetic tree -- a tree having its leaves univocally labeled by elements of $X$…

Data Structures and Algorithms · Computer Science 2016-04-12 Julien Baste , Christophe Paul , Ignasi Sau , Celine Scornavacca

An evolutionary tree (phylogenetic tree) is a binary, rooted, unordered tree that models the evolutionary history of currently living species in which leaves are labeled by species. In this paper, we investigate the problem of finding the…

Populations and Evolution · Quantitative Biology 2013-04-02 Soheil Jahangiri Tazehkand , Seyed Naser Hashemi , Hadi Poormohammadi

Genomes and genes diversify during evolution; however, it is unclear to what extent genes still retain the relationship among species. Model species for molecular phylogenetic studies include yeasts and viruses whose genomes were sequenced…

Genomics · Quantitative Biology 2008-06-09 Yunfeng Shan , Xiu-Qing Li

Choi et. al (2011) introduced a minimum spanning tree (MST)-based method called CLGrouping, for constructing tree-structured probabilistic graphical models, a statistical framework that is commonly used for inferring phylogenetic trees.…

Combinatorics · Mathematics 2017-01-12 Prabhav Kalaghatgi , Thomas Lengauer

We present an algorithm for computing a maximum agreement subtree of two unrooted evolutionary trees. It takes O(n^{1.5} log n) time for trees with unbounded degrees, matching the best known time complexity for the rooted case. Our…

Computational Engineering, Finance, and Science · Computer Science 2007-05-23 Ming-Yang Kao , Tak-Wah Lam , Wing-Kin Sung , Hing-Fung Ting
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