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Nanophotonics offers a promising range of applications spanning from the development of efficient solar cells to quantum communications and biosensing. However, the ability to efficiently couple fluorescent emitters with nanostructured…

Fluorescence imaging is an essential diagnostic tool in many fields, but diffraction-limited optical imaging at depth is limited by scattering. Here, we present a method based on multiple random illuminations, combined with a computational…

Optics · Physics 2026-03-30 Lei Zhu , Tengfei Wu , Bernhard Rauer , Hilton B. de Aguiar , Sylvain Gigan

Molecule-surface interaction is key to many physical and chemical processes at interfaces. Here, we show that the dynamics of single molecules on a surface under ultrahigh vacuum can be resolved using fluorescence imaging. By adapting…

Chemical Physics · Physics 2021-10-19 Tianyu Fang , Florian Elsen , Nick Vogeley , Daqing Wang

In this paper, we review spatial light interference microscopy (SLIM), a common-path, phase-shifting interferometer, built onto a phase-contrast microscope, with white-light illumination. As one of the most sensitive quantitative phase…

Optics · Physics 2020-12-17 Xi Chen , Mikhail E. Kandel , Gabriel Popescu

We demonstrate a new computational illumination technique that achieves large space-bandwidth-time product, for quantitative phase imaging of unstained live samples in vitro. Microscope lenses can have either large field of view (FOV) or…

Optics · Physics 2015-10-16 Lei Tian , Ziji Liu , Li-Hao Yeh , Michael Chen , Jingshan Zhong , Laura Waller

We demonstrate fluorescence microscopy of individual fermionic potassium atoms in a 527-nm-period optical lattice. Using electromagnetically induced transparency (EIT) cooling on the 770.1-nm D$_1$ transition of $^{40}$K, we find that atoms…

Quantum Gases · Physics 2015-12-15 G. J. A. Edge , R. Anderson , D. Jervis , D. C. McKay , R. Day , S. Trotzky , J. H. Thywissen

We introduce a imaging modality that works by transiently masking image-subregions during a single exposure of a CCD frame. By offsetting subregion exposure time, temporal information is embedded within each stored frame, allowing…

Quantitative Methods · Quantitative Biology 2016-09-08 Gil Bub , Matthias Tecza , Michiel Helmes , Peter Lee , Peter Kohl

A sparsity-exploiting algorithm intended for few-view Single Photon Emission Computed Tomography (SPECT) reconstruction is proposed and characterized. The algorithm models the object as piecewise constant subject to a blurring operation. To…

Medical Physics · Physics 2012-12-05 Paul A Wolf , Jakob H Jørgensen , Taly G Schmidt , Emil Y Sidky

Improving the resolution of fluorescence microscopy beyond the diffraction limit can be achievedby acquiring and processing multiple images of the sample under different illumination conditions.One of the simplest techniques, Random…

Near-infrared (NIR) hyperspectral imaging is widely used to reveal morphological and chemical information. However, conventional spectral imagers usually rely on costly focal plane arrays and suffer from data redundancy and inefficiencies…

Optics · Physics 2026-05-26 Ben Sun , Kun Huang , Zhibin Zhao , Beibei Dong , Jianan Fang , Heping Zeng

We introduce a single-frame diffractive imaging method called randomized probe imaging (RPI). In RPI, a sample is illuminated by a structured probe field containing speckles smaller than the sample's typical feature size. Quantitative…

Single-pixel imaging leverages a single-pixel detector and structured illumination patterns to reconstruct images, offering a cost-effective solution for imaging across a wide range of wavelengths, such as x-ray and terahertz. However, the…

Optics · Physics 2025-02-07 Hamidreza Oliaei-Moghadam

We have developed a single-shot imaging technique that can capture ultrafast events occurring on femtosecond to picosecond time scales. The technique is based on an optical pump-probe method, in which multiple time-delayed femtosecond…

Instrumentation and Detectors · Physics 2018-11-14 Sarang Yeola , Donghoon Kuk , Ki-Yong Kim

In traditional optical imaging systems, the spatial resolution is limited by the physics of diffraction, which acts as a low-pass filter. The information on sub-wavelength features is carried by evanescent waves, never reaching the camera,…

Optics · Physics 2018-12-13 Oren Solomon , Yonina C. Eldar , Maor Mutzafi , Mordechai Segev

Fluorescence molecular tomography (FMT) is a promising modality for non-invasive imaging of internal fluorescence agents in biological tissues especially in small animal models, with applications in diagnosis, therapy, and drug design. In…

Optics · Physics 2023-08-09 Wenxiang Cong , Ge Wang

Capturing ultrafast transient phenomena conventionally requires streak cameras or computational imaging based on compressed sensing, which lead to complex and costly systems. In this Letter, we demonstrate, to the best of our knowledge, the…

Optics · Physics 2026-05-01 Dilem Eşlik , Bahadır Utku Kesgin , Uğur Teğin

Previous attempts to integrate Neural Radiance Fields (NeRF) into the Simultaneous Localization and Mapping (SLAM) framework either rely on the assumption of static scenes or require the ground truth camera poses, which impedes their…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Chengyao Duan , Zhiliu Yang

Recent technological advances in cutting-edge ultrasensitive fluorescence microscopy have allowed single-molecule imaging experiments in living cells across all three domains of life to become commonplace. Single-molecule live-cell data is…

Biomolecules · Quantitative Biology 2015-04-15 Mark Leake

Efficient simulation of photon registrations in single-photon LiDAR (SPL) is essential for applications such as depth estimation under high-flux conditions, where hardware dead time significantly distorts photon measurements. However, the…

Signal Processing · Electrical Eng. & Systems 2025-06-02 Weijian Zhang , Hashan K. Weerasooriya , Stanley Chan

A method is proposed for assessing the temporal resolution of Structured Illumination Microscopy (SIM), by tracking the amplitude of different spatial frequency components over time, and comparing them to a temporally-oscillating…

Optics · Physics 2020-08-05 Abderrahim Boualam , Christopher J Rowlands