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Protein language models (PLMs) have shown promise in improving the understanding of protein sequences, contributing to advances in areas such as function prediction and protein engineering. However, training these models from scratch…

Machine Learning · Computer Science 2024-12-19 Shivasankaran Vanaja Pandi , Bharath Ramsundar

Protein language models (PLMs) have advanced computational protein science through large-scale pretraining and scalable architectures. In parallel, reinforcement learning (RL) has broadened exploration and enabled precise multi-objective…

Unsupervised multitask pre-training has been the critical method behind the recent success of language models (LMs). However, supervised multitask learning still holds significant promise, as scaling it in the post-training stage trends…

Computation and Language · Computer Science 2024-12-02 Daixuan Cheng , Yuxian Gu , Shaohan Huang , Junyu Bi , Minlie Huang , Furu Wei

This paper introduces diffusion protein language model (DPLM), a versatile protein language model that demonstrates strong generative and predictive capabilities for protein sequences. We first pre-train scalable DPLMs from…

Machine Learning · Computer Science 2024-10-17 Xinyou Wang , Zaixiang Zheng , Fei Ye , Dongyu Xue , Shujian Huang , Quanquan Gu

Learning to generalise from limited data is a fundamental challenge for both artificial and biological systems. A common strategy is to extract reusable structure from abundant unlabelled data, enabling efficient adaptation to new tasks…

Machine Learning · Computer Science 2026-05-20 Valentina Njaradi , Clémentine Dominé , Rachel Swanson , Marco Mondelli , Andrew Saxe

We present an efficient method of utilizing pretrained language models, where we learn selective binary masks for pretrained weights in lieu of modifying them through finetuning. Extensive evaluations of masking BERT and RoBERTa on a series…

Computation and Language · Computer Science 2020-10-13 Mengjie Zhao , Tao Lin , Fei Mi , Martin Jaggi , Hinrich Schütze

With the development of next generation sequencing techniques, it is fast and cheap to determine protein sequences but relatively slow and expensive to extract useful information from protein sequences because of limitations of traditional…

Quantitative Methods · Quantitative Biology 2017-10-20 Renzhi Cao , Colton Freitas , Leong Chan , Miao Sun , Haiqing Jiang , Zhangxin Chen

News recommendation aims to predict click behaviors based on user behaviors. How to effectively model the user representations is the key to recommending preferred news. Existing works are mostly focused on improvements in the supervised…

Information Retrieval · Computer Science 2023-10-31 Guangyuan Ma , Hongtao Liu , Xing Wu , Wanhui Qian , Zhepeng Lv , Qing Yang , Songlin Hu

How can we extend a pre-trained model to many language understanding tasks, without labeled or additional unlabeled data? Pre-trained language models (PLMs) have been effective for a wide range of NLP tasks. However, existing approaches…

Computation and Language · Computer Science 2023-05-29 Xuandong Zhao , Siqi Ouyang , Zhiguo Yu , Ming Wu , Lei Li

In many real-world scenarios, labeled data for a specific machine learning task is costly to obtain. Semi-supervised training methods make use of abundantly available unlabeled data and a smaller number of labeled examples. We propose a new…

Computer Vision and Pattern Recognition · Computer Science 2017-06-06 Philip Häusser , Alexander Mordvintsev , Daniel Cremers

Many tasks in natural language processing can be viewed as multi-label classification problems. However, most of the existing models are trained with the standard cross-entropy loss function and use a fixed prediction policy (e.g., a…

Computation and Language · Computer Science 2019-09-11 Jiawei Wu , Wenhan Xiong , William Yang Wang

Self-training is one of the earliest and simplest semi-supervised methods. The key idea is to augment the original labeled dataset with unlabeled data paired with the model's prediction (i.e. the pseudo-parallel data). While self-training…

Machine Learning · Computer Science 2020-10-20 Junxian He , Jiatao Gu , Jiajun Shen , Marc'Aurelio Ranzato

Multi-role dialogue understanding comprises a wide range of diverse tasks such as question answering, act classification, dialogue summarization etc. While dialogue corpora are abundantly available, labeled data, for specific learning…

Computation and Language · Computer Science 2020-03-12 Tianyi Wang , Yating Zhang , Xiaozhong Liu , Changlong Sun , Qiong Zhang

Pretext training followed by task-specific fine-tuning has been a successful approach in vision and language domains. This paper proposes a self-supervised pretext training framework tailored to event sequence data. We introduce a novel…

Machine Learning · Computer Science 2024-02-19 Yimu Wang , He Zhao , Ruizhi Deng , Frederick Tung , Greg Mori

Dataset pruning reduces the storage and training costs of deep learning by selecting an informative subset from a large dataset. However, most existing pruning methods require fully labeled data, which limits their applicability in…

Machine Learning · Computer Science 2026-05-25 Yeseul Cho , Baekrok Shin , Changmin Kang , Chulhee Yun

Large-scale visual language models are widely used as pre-trained models and then adapted for various downstream tasks. While humans are known to efficiently learn new tasks from a few examples, deep learning models struggle with adaptation…

Computer Vision and Pattern Recognition · Computer Science 2023-05-04 Chuhan Zhang , Antoine Miech , Jiajun Shen , Jean-Baptiste Alayrac , Pauline Luc

Pre-trained Large Language Models (LLMs) often struggle on out-of-domain datasets like healthcare focused text. We explore specialized pre-training to adapt smaller LLMs to different healthcare datasets. Three methods are assessed:…

Computation and Language · Computer Science 2024-04-01 Niall Taylor , Dan Schofield , Andrey Kormilitzin , Dan W Joyce , Alejo Nevado-Holgado

Given the complexity of combinations of tasks, languages, and domains in natural language processing (NLP) research, it is computationally prohibitive to exhaustively test newly proposed models on each possible experimental setting. In this…

Computation and Language · Computer Science 2020-05-05 Mengzhou Xia , Antonios Anastasopoulos , Ruochen Xu , Yiming Yang , Graham Neubig

Leveraging task-aware annotated data as supervised signals to assist with self-supervised learning on large-scale unlabeled data has become a new trend in pre-training language models. Existing studies show that multi-task learning with…

Computation and Language · Computer Science 2022-10-13 Zhuosheng Zhang , Shuohang Wang , Yichong Xu , Yuwei Fang , Wenhao Yu , Yang Liu , Hai Zhao , Chenguang Zhu , Michael Zeng

Language-image pre-training is an effective technique for learning powerful representations in general domains. However, when directly turning to person representation learning, these general pre-training methods suffer from unsatisfactory…

Computer Vision and Pattern Recognition · Computer Science 2024-05-30 Jialong Zuo , Jiahao Hong , Feng Zhang , Changqian Yu , Hanyu Zhou , Changxin Gao , Nong Sang , Jingdong Wang