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The exploitation of large-scale population data has the potential to improve healthcare by discovering and understanding patterns and trends within this data. To enable high throughput analysis of cardiac imaging data automatically, a…

Image and Video Processing · Electrical Eng. & Systems 2019-01-14 Rahman Attar , Marco Pereanez , Ali Gooya , Xenia Alba , Le Zhang , Stefan K. Piechnik , Stefan Neubauer , Steffen E. Petersen , Alejandro F. Frangi

Objective: Exploit accelerometry data for an automatic, reliable, and prompt detection of spontaneous circulation during cardiac arrest, as this is both vital for patient survival and practically challenging. Methods: We developed a machine…

Signal Processing · Electrical Eng. & Systems 2023-02-13 Wolfgang J. Kern , Simon Orlob , Andreas Bohn , Wolfgang Toller , Jan Wnent , Jan-Thorsten Gräsner , Martin Holler

Predicting the electrical behavior of the heart, from the cellular scale to the tissue level, relies on the formulation and numerical approximation of coupled nonlinear dynamical systems. These systems describe the cardiac action potential,…

Computational Physics · Physics 2021-01-27 Stefania Fresca , Andrea Manzoni , Luca Dedè , Alfio Quarteroni

Sharing a common clock signal among the nodes is crucial for communication in synchronized networks. This work presents a heartbeat-based synchronization scheme for body-worn nodes. The principles of this coordination technique combined…

Networking and Internet Architecture · Computer Science 2020-05-13 Robin Benarrouch , Ali Moin , Flavien Solt , Antoine Frappé , Andreia Cathelin , Andreas Kaiser , Jan Rabaey

Graphical processing units (GPUs) promise to revolutionize scientific computing in the near future. Already, they allow almost real-time integration of simplified numerical models of cardiac tissue dynamics. However, the integration methods…

Chaotic Dynamics · Physics 2013-12-10 Christopher D. Marcotte , Roman O. Grigoriev

In this paper we develop a numerical scheme for approximating a $d$-dimensional chemotaxis-Navier-Stokes system, $d=2,3$, modeling cellular swimming in incompressible fluids. This model describes the chemotaxis-fluid interaction in cases…

The cardiovascular system is composed of the heart, blood and blood vessels. Regarding the heart, cardiac conditions are determined by the electrocardiogram, that is a noninvasive medical procedure. In this work, we propose autoregressive…

Optimization and uncertainty quantification have been playing an increasingly important role in computational hemodynamics. However, existing methods based on principled modeling and classic numerical techniques have faced significant…

Medical Physics · Physics 2022-09-07 Pan Du , Xiaozhi Zhu , Jian-Xun Wang

Global single-valued biomarkers of cardiac function typically used in clinical practice, such as ejection fraction, provide limited insight on the true 3D cardiac deformation process and hence, limit the understanding of both healthy and…

Image and Video Processing · Electrical Eng. & Systems 2023-07-21 Marcel Beetz , Abhirup Banerjee , Vicente Grau

The present article proposes a partitioned Dirichlet-Neumann algorithm, that allows to address unique challenges arising from a novel mixed-dimensional coupling of very slender fibers embedded in fluid flow using a regularized mortar-type…

Numerical Analysis · Mathematics 2023-12-04 Nora Hagmeyer , Matthias Mayr , Alexander Popp

In computational modelling of coronary haemodynamics, imposing patient-specific flow conditions is paramount, yet often impractical due to resource and time constraints, limiting the ability to perform a large number of simulations…

Medical Physics · Physics 2025-03-03 Mingzi Zhang , Hamed Keramati , Ramtin Gharleghi , Susann Beier

Finite element analysis (FEA) forms the cornerstone of modeling cardiac biomechanics but is computationally expensive, limiting its clinical application for digital twin creation, which often requires tens to hundreds of simulations to…

Medical Physics · Physics 2025-04-29 Lei Shi , Yurui Chen , Vijay Vedula

Predictive modeling of blood flow and pressure have numerous applications ranging from non-invasive assessment of functional significance of disease to planning invasive procedures. While several such predictive modeling techniques have…

Accurate 3D cardiac reconstruction from cine magnetic resonance imaging (cMRI) is crucial for improved cardiovascular disease diagnosis and understanding of the heart's motion. However, current cardiac MRI-based reconstruction technology…

Image and Video Processing · Electrical Eng. & Systems 2023-08-21 Xiaoxiao He , Chaowei Tan , Ligong Han , Bo Liu , Leon Axel , Kang Li , Dimitris N. Metaxas

Cardiac arrhythmias are a major cause of morbidity and mortality increasing the risk of stroke, heart failure, and sudden cardiac death. Imageless electrocardiographic imaging (ECGI) provides a non invasive alternative to electrical mapping…

Congenital heart disease (CHD) encompasses a spectrum of cardiovascular structural abnormalities, often requiring customized treatment plans for individual patients. Computational modeling and analysis of these unique cardiac anatomies can…

Tissues and Organs · Quantitative Biology 2023-11-09 Fanwei Kong , Sascha Stocker , Perry S. Choi , Michael Ma , Daniel B. Ennis , Alison Marsden

The numerical simulation of the 3D incompressible Euler equation is analyzed with respect to different integration methods. The numerical schemes we considered include spectral methods with different strategies for dealiasing and two…

Fluid Dynamics · Physics 2009-11-13 Tobias Grafke , Holger Homann , Juergen Dreher , Rainer Grauer

This paper presents a projection-based reduced order modelling (ROM) framework for unsteady parametrized optimal control problems (OCP$_{(\mu)}$s) arising from cardiovascular (CV) applications. In real-life scenarios, accurately defining…

We develop two mathematical lumped parameter models for blood pressure distribution in the Fontan blood flow circulation: an ODE based spatially homogeneous model and a PDE based spatially inhomogeneous model. We present numerical…

Analysis of PDEs · Mathematics 2018-06-08 J. P. Keener , M. Chugunova , R. M. Taranets , M. G. Doyle

We present formulations and numerical algorithms for solving diffeomorphic shape matching problems. We formulate shape matching as a variational problem governed by a dynamical system that models the flow of diffeomorphism $f_t \in…

Optimization and Control · Mathematics 2023-07-20 Andreas Mang , Jiwen He , Robert Azencott