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Personalized virtual heart models have demonstrated increasing potential for clinical use, although the estimation of their parameters given patient-specific data remain a challenge. Traditional physics-based modeling approaches are…

Signal Processing · Electrical Eng. & Systems 2024-03-26 Xiajun Jiang , Sumeet Vadhavkar , Yubo Ye , Maryam Toloubidokhti , Ryan Missel , Linwei Wang

In the present chapter we focus on the fundamentals of non-grid-conforming numerical approaches to simulating particulate flows, implementation issues and grid convergence vs. available reference data. The main idea is to avoid adapting the…

Fluid Dynamics · Physics 2024-12-11 Markus Uhlmann , Jos Derksen , Anthony Wachs , Lian-Ping Wang , Manuel Moriche

3D motion estimation from cine cardiac magnetic resonance (CMR) images is important for the assessment of cardiac function and the diagnosis of cardiovascular diseases. Current state-of-the art methods focus on estimating dense…

Image and Video Processing · Electrical Eng. & Systems 2023-09-26 Qingjie Meng , Wenjia Bai , Declan P O'Regan , and Daniel Rueckert

The purpose of this study is to present a new semi-automated methodology for three-dimensional (3D) reconstruction of coronary arteries and their plaque morphology using Computed Tomography Angiography (CTA) images. The methodology is…

In this paper, we first propose a filter-based continuous Ensemble Eddy Viscosity (EEV) model for stochastic turbulent flow problems. We then propose a generic algorithm for a family of fully discrete, grad-div regularized, efficient…

Numerical Analysis · Mathematics 2025-08-15 Brandiece N. Berry , Md Mahmudul Islam , Muhammad Mohebujjaman , Neethu Suma Raveendran

This study performs parameter inference in a partial differential equations system of pulmonary circulation. We use a fluid dynamics network model that takes selected parameter values and mimics the behaviour of the pulmonary haemodynamics…

Computational fluid dynamics (CFD) based simulation of coronary blood flow provides valuable hemodynamic markers, such as pressure gradients, for diagnosing coronary artery disease (CAD). However, CFD is computationally expensive,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-12 Rene Lisasi , Michele Esposito , Chen Zhao

Non-invasive assessment of the electrical activation pattern can significantly contribute to the diagnosis and treatment of cardiac arrhythmias, due to faster and safer diagnosis, improved surgical planning and easier follow-up. One…

Medical Physics · Physics 2024-01-09 Nathan Dermul , Hans Dierckx

In this paper we will address the problem of developing mathematical models for the numerical simulation of the human circulatory system. In particular, we will focus our attention on the problem of haemodynamics in large human arteries.

Dynamical Systems · Mathematics 2007-05-23 Alfio Quarteroni

Accurate reconstruction of multi-chamber cardiac anatomy from medical images is a cornerstone for patient-specific modeling, physiological simulation, and interventional planning. However, current reconstruction pipelines fundamentally rely…

Computer Vision and Pattern Recognition · Computer Science 2025-12-16 Chenyu Zhang , Yihao Luo , Lei Zhu , Martyn G Boutelle , Choon Hwai Yap , Guang Yang

- Modeling Human cardiovascular system is always an important issue. One of the most effective methods is using lumped model to reach to a complete model of human cardiovascular system. Such modeling with advanced considerations is used in…

In this work, we introduce an algorithmic approach to generate microvascular networks starting from larger vessels that can be reconstructed without noticeable segmentation errors. Contrary to larger vessels, the reconstruction of…

Computational Engineering, Finance, and Science · Computer Science 2020-07-10 Tobias Köppl , Ettore Vidotto , Barbara Wohlmuth

We are interested in a reduced order method for the efficient simulation of blood flow in arteries. The blood dynamics is modeled by means of the incompressible Navier-Stokes equations. Our algorithm is based on an approximated…

Numerical Analysis · Mathematics 2021-04-07 Luca Pegolotti , Martin Pfaller , Alison Marsden , Simone Deparis

Convolutional neural networks (CNN) have demonstrated their ability to segment 2D cardiac ultrasound images. However, despite recent successes according to which the intra-observer variability on end-diastole and end-systole images has been…

Image and Video Processing · Electrical Eng. & Systems 2022-05-09 Nathan Painchaud , Nicolas Duchateau , Olivier Bernard , Pierre-Marc Jodoin

Electrocardiographic imaging (ECGI) seeks to reconstruct cardiac electrical activity from body-surface potentials noninvasively. However, the associated inverse problem is severely ill-posed and requires robust regularization. While…

Numerical Analysis · Mathematics 2026-02-16 Manuel Haas , Thomas Grandits , Thomas Pinetz , Thomas Beiert , Simone Pezzuto , Alexander Effland

Advances in computational science offer a principled pipeline for predictive modeling of cardiovascular flows and aspire to provide a valuable tool for monitoring, diagnostics and surgical planning. Such models can be nowadays deployed on…

Machine Learning · Computer Science 2019-09-19 Georgios Kissas , Yibo Yang , Eileen Hwuang , Walter R. Witschey , John A. Detre , Paris Perdikaris

Personalized cardiac diagnostics require accurate reconstruction of myocardial displacement fields from sparse clinical imaging data, yet current methods often demand intrusive access to computational models. In this work, we apply the…

Purpose: Echocardiography is commonly used as a non-invasive imaging tool in clinical practice for the assessment of cardiac function. However, delineation of the left ventricle is challenging due to the inherent properties of ultrasound…

Image and Video Processing · Electrical Eng. & Systems 2021-09-07 Deepa Krishnaswamy , Abhilash R. Hareendranathan , Tan Suwatanaviroj , Pierre Boulanger , Harald Becher , Michelle Noga , Kumaradevan Punithakumar

Time-resolved three-dimensional flow MRI (4D flow MRI) provides a unique non-invasive solution to visualize and quantify hemodynamics in blood vessels such as the aortic arch. However, most current analysis methods for arterial 4D flow MRI…

Computer Vision and Pattern Recognition · Computer Science 2024-07-31 Simone Garzia , Patryk Rygiel , Sven Dummer , Filippo Cademartiri , Simona Celi , Jelmer M. Wolterink

Rigorous computer simulations of propagating electromagnetic fields have become an important tool for optical metrology and optics design of nanostructured components. As has been shown in previous benchmarks some of the presently used…

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