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The brain's biological age has been considered as a promising candidate for a neurologically significant biomarker. However, recent results based on longitudinal magnetic resonance imaging data have raised questions on its interpretation. A…

Neurons and Cognition · Quantitative Biology 2023-10-12 Lukas AW Gemein , Robin T Schirrmeister , Joschka Boedecker , Tonio Ball

Brain disorders in the early and late life of humans potentially share pathological alterations in brain functions. However, the key evidence from neuroimaging data for pathological commonness remains unrevealed. To explore this hypothesis,…

Artificial Intelligence · Computer Science 2023-02-24 Mianxin Liu , Jingyang Zhang , Yao Wang , Yan Zhou , Fang Xie , Qihao Guo , Feng Shi , Han Zhang , Qian Wang , Dinggang Shen

Important applications of advancements in machine learning, are in the area of healthcare, more so for neurological disorder detection. A crucial step towards understanding the neurological status, is to estimate the brain age using…

Image and Video Processing · Electrical Eng. & Systems 2024-07-10 Vamshi Krishna Kancharla , Neelam Sinha

Brain age gap estimation (BrainAGE) is a promising imaging-derived biomarker of neurobiological aging and disease risk, yet current approaches rely predominantly on T1-weighted structural MRI (T1w), overlooking functional vascular changes…

Image and Video Processing · Electrical Eng. & Systems 2025-12-10 Jordan Jomsky , Kay C. Igwe , Zongyu Li , Yiren Zhang , Max Lashley , Tal Nuriel , Andrew Laine , Jia Guo

Computational neuroimaging involves analyzing brain images or signals to provide mechanistic insights and predictive tools for human cognition and behavior. While diffusion models have shown stability and high-quality generation in natural…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Haokai Zhao , Haowei Lou , Lina Yao , Wei Peng , Ehsan Adeli , Kilian M Pohl , Yu Zhang

The surface morphology of the developing mammalian brain is crucial for understanding brain function and dysfunction. Computational modeling offers valuable insights into the underlying mechanisms for early brain folding. Recent findings…

Neurons and Cognition · Quantitative Biology 2024-09-06 Jixin Hou , Zhengwang Wu , Xianyan Chen , Li Wang , Dajiang Zhu , Tianming Liu , Gang Li , Xianqiao Wang

We introduce the Aging Multiverse, a framework for generating multiple plausible facial aging trajectories from a single image, each conditioned on external factors such as environment, health, and lifestyle. Unlike prior methods that model…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Bang Gong , Luchao Qi , Jiaye Wu , Zhicheng Fu , Chunbo Song , David W. Jacobs , John Nicholson , Roni Sengupta

Recently, there has been increased interest in fusing multimodal imaging to better understand brain organization. Specifically, accounting for knowledge of anatomical pathways connecting brain regions should lead to desirable outcomes such…

Applications · Statistics 2018-03-02 Ixavier A. Higgins , Suprateek Kundu , Ying Guo

Brain aging involves structural and functional changes and therefore serves as a key biomarker for brain health. Combining structural magnetic resonance imaging (sMRI) and functional magnetic resonance imaging (fMRI) has the potential to…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Abd Ur Rehman , Azka Rehman , Muhammad Usman , Abdullah Shahid , Sung-Min Gho , Aleum Lee , Tariq M. Khan , Imran Razzak

Predicting brain maturity using noninvasive magnetic resonance images (MRI) can distinguish different age groups and help to assess neurodevelopmental disorders. However, group-wise differences are often less informative for assessing…

Neurons and Cognition · Quantitative Biology 2014-12-17 Cheol E. Han , Luis R. Peraza , John-Paul Taylor , Marcus Kaiser

Chronological age of healthy people is able to be predicted accurately using deep neural networks from neuroimaging data, and the predicted brain age could serve as a biomarker for detecting aging-related diseases. In this paper, a novel 3D…

Image and Video Processing · Electrical Eng. & Systems 2021-06-08 Jian Cheng , Ziyang Liu , Hao Guan , Zhenzhou Wu , Haogang Zhu , Jiyang Jiang , Wei Wen , Dacheng Tao , Tao Liu

Age prediction using brain imaging, such as MRIs, has achieved promising results, with several studies identifying the model's residual as a potential biomarker for chronic disease states. In this study, we developed a brain age predictive…

Machine Learning · Computer Science 2025-04-22 Shahrzad Jamshidi , Arthur Bousquet , Sugata Banerji , Mark F. Conneely , Bita Aslrousta

In this paper, we propose an unsupervised framework based on normalizing flows that harmonizes MR images to mimic the distribution of the source domain. The proposed framework consists of three steps. First, a shallow harmonizer network is…

Computer Vision and Pattern Recognition · Computer Science 2023-01-30 Farzad Beizaee , Christian Desrosiers , Gregory A. Lodygensky , Jose Dolz

Given datasets from multiple domains, a key challenge is to efficiently exploit these data sources for modeling a target domain. Variants of this problem have been studied in many contexts, such as cross-domain translation and domain…

Machine Learning · Computer Science 2019-12-24 Aditya Grover , Christopher Chute , Rui Shu , Zhangjie Cao , Stefano Ermon

Background: We have previously demonstrated that cortical folding across mammalian species follows a universal scaling law that can be derived from a simple theoretical model. The same scaling law has also been shown to hold across brains…

Neurons and Cognition · Quantitative Biology 2020-06-01 Yujiang Wang , Joe Necus , Luis Peraza Rodriguez , Peter Neal Taylor , Bruno Mota

Age progression and regression refers to aesthetically render-ing a given face image to present effects of face aging and rejuvenation, respectively. Although numerous studies have been conducted in this topic, there are two major problems:…

Computer Vision and Pattern Recognition · Computer Science 2019-10-08 Qi Li , Yunfan Liu , Zhenan Sun

In human face-based biometrics, gender classification and age estimation are two typical learning tasks. Although a variety of approaches have been proposed to handle them, just a few of them are solved jointly, even so, these joint methods…

Computer Vision and Pattern Recognition · Computer Science 2016-09-15 Qing Tian , Songcan Chen

The ability to determine if the brain is developing normally is a key component of pediatric neuroradiology and neurology. Brain magnetic resonance imaging (MRI) of infants demonstrates a specific pattern of development beyond simply…

Image and Video Processing · Electrical Eng. & Systems 2020-10-09 M. Shabanian , A. Siddiqui , H. Chen , J. P. DeVincenzo

Brain imaging analysis is fundamental in neuroscience, providing valuable insights into brain structure and function. Traditional workflows follow a sequential pipeline-brain extraction, registration, segmentation, parcellation, network…

Image and Video Processing · Electrical Eng. & Systems 2025-02-27 Yao Su , Keqi Han , Mingjie Zeng , Lichao Sun , Liang Zhan , Carl Yang , Lifang He , Xiangnan Kong

Structural and appearance changes in brain imaging over time are crucial indicators of neurodevelopment and neurodegeneration. The rapid advancement of large-scale generative models provides a promising backbone for modeling these complex…

Graphics · Computer Science 2025-03-14 Gexin Huang , Zhangsihao Yang , Yalin Wang , Guido Gerig , Mengwei Ren , Xiaoxiao Li
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