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We analyze an optimal control version of a simple SIRS epidemiology model. The policy maker can adopt policies to diminish the contact rate between infected and susceptible individuals, at a specific economic cost. The arrival of a vaccine…
We use a stochastic Markovian dynamics approach to describe the spreading of vector-transmitted diseases, like dengue, and the threshold of the disease. The coexistence space is composed by two structures representing the human and mosquito…
In this paper, we study a novel control method for a generalized SIS epidemic process. In particular, we use predictive control to design optimal protective resource distribution strategies which balance the need to eliminate the epidemic…
In this paper, we study an optimal control problem of a communicable disease in a prison population. In order to control the spread of the disease inside a prison, we consider an active case-finding strategy, consisting on screening a…
We study first order necessary conditions for an optimal control problem of a Susceptible-Infected-Recovered (SIR) model with limitations on the duration of the quarantine. The control is done by means of the reproduction number, i.e., the…
We consider a behavioral-feedback SIR epidemic model, in which the infection rate depends in feedback on the fractions of susceptible and infected agents, respectively. The considered model allows one to account for endogenous adaptation…
Dengue is a vector borne infectious disease. The disease is transmitted byAedes mosquitoes. In the present work, SEIR - SEI compartmental epidemiological model is used to describe dengue disease transmission dynamics. The human population…
We study the impact of model parameter uncertainty on optimally mitigating the spread of epidemics. We capture the epidemic spreading process using a susceptible-infected-removed (SIR) epidemic model and consider testing for isolation as…
This paper is about numerical control of HIV propagation. The contribution of the paper is threefold: first, a novel model of HIV propagation is proposed; second, the methods from numerical optimal control are successfully applied to the…
Aedes aegypti is a known vector of Dengue, Chikungunya and Zika and the goal of this study is to propose the first mathematical model to describe the dynamic transmission of these three diseases. We present two preliminary models that…
Dengue, a mosquito-borne disease, continues to pose a persistent public health challenge in urban areas, particularly in tropical regions such as Singapore. Effective and affordable control requires anticipating where transmission risks are…
In mathematical epidemiology, epidemic control often aims at driving the number of infected individuals to zero, asymptotically. However , during the transitory phase, the number of infected can peak at high values. In this paper, we…
Optimal control problems reflecting the finding of effective quarantine strategies are considered for two control SEIR~type models describing the spread of the COVID-19 virus in the human population. The properties of the corresponding…
Every year, the Aedes aegypti mosquito infects millions of people with diseases such as dengue, zika, chikungunya, and urban yellow fever. The main form to combat these diseases is to avoid mosquito reproduction by searching for and…
Mosquito vector competence is usually represented as a process in which once virus is detected in saliva, mosquitoes are assumed to remain infectious for life, implying an irreversible transition to the transmitting state. However, some…
We propose and investigate a delayed model that studies the relationship between HIV and the immune system during the natural course of infection and in the context of antiviral treatment regimes. Sufficient criteria for local asymptotic…
We investigate the time-optimal control problem in SIR (Susceptible-Infected-Recovered) epidemic models, focusing on different control policies: vaccination, isolation, culling, and reduction of transmission. Applying the Pontryagin's…
Dengue is a vector-borne disease transmitted by Aedes mosquitoes. The worldwide spread of these mosquitoes and the increasing disease burden have emphasized the need for a spatio-temporal risk map capable of assessing dengue outbreak…
As offered by the World Health Organisation (WHO), close to half of the population in the world's resides in dengue-risk zones. Dengue viruses are transmitted to individuals by Aedes mosquito species infected bite (Ae. Albopictus of Ae.…
In social networks, control of rumor spread is an active area of research. SIR model is generally used to study the rumor dynamics in network while considering the rumor as an epidemic. In disease spreading model, epidemic is controlled by…