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Controlling an epidemiological model is often performed using optimal control theory techniques for which the solution depends on the equations of the control system, objective functional and possible state and/or control constraints. In…

Optimization and Control · Mathematics 2021-11-25 Loïc Michel , Cristiana J. Silva , Delfim F. M. Torres

We provide easy and readable GNU Octave/MATLAB code for the simulation of mathematical models described by ordinary differential equations and for the solution of optimal control problems through Pontryagin's maximum principle. For that, we…

Optimization and Control · Mathematics 2019-12-23 Carlos Campos , Cristiana J. Silva , Delfim F. M. Torres

We consider the problem of the optimal allocation of vaccination and protection measures for the Susceptible-Infected-Recovered-Infected (SIRI) epidemiological model, which generalizes the classical Susceptible-Infected-Recovered (SIR) and…

Optimization and Control · Mathematics 2025-05-09 Urmee Maitra , Ashish R. Hota , Rohit Gupta , Alfred O. Hero

Social distancing strategies have been adopted by governments to manage the COVID-19 pandemic, since the first outbreak began. However, further epidemic waves keep out the return of economic and social activities to their standard levels of…

Optimization and Control · Mathematics 2021-06-07 J. E. Sereno , A. D' Jorge , A. Ferramosca , E. A. Hernandez-Vargas , A. H. Gonzalez

Mosquito-borne diseases cause several hundred thousand deaths every year. Deciphering mosquito host-seeking behavior is essential to prevent disease transmission through mosquito capture and surveillance. Despite recent substantial…

Biological Physics · Physics 2025-05-22 Christopher Zuo , Chenyi Fei , Alexander E. Cohen , Soohwan Kim , Ring T. Carde , Jörn Dunkel , David L. Hu

This paper presents a vaccination-based control strategy for a SEIR (susceptible plus infected plus infectious plus removed populations) propagation disease model. The model takes into account the total population amounts as a refrain for…

Dynamical Systems · Mathematics 2011-03-28 M. De la Sen , A. Ibeas , S. Alonso-Quesada

Wolbachia is a genus of endosymbiotic bacteria that can infect mosquitoes and reduce their ability to transmit dengue virus. Although the bacterium is transmitted vertically from infected mothers to their offspring, it can be difficult to…

Populations and Evolution · Quantitative Biology 2015-10-06 Ling Xue , Carrie A. Manore , Panpim Thongsripong , James M. Hyman

We study the problem of optimal control of the stochastic SIR model. Models of this type are used in mathematical epidemiology to capture the time evolution of highly infectious diseases such as COVID-19. Our approach relies on…

Populations and Evolution · Quantitative Biology 2020-05-04 Andrew Lesniewski

This study presents a deterministic model to investigate rabies transmission dynamics, incorporating environmental effects and control strategies using optimal control theory. Qualitative and quantitative analyses reveal that the…

Optimization and Control · Mathematics 2025-09-05 Mfano Charles , Sayoki G. Mfinanga , G. A. Lyakurwa , Delfim F. M. Torres , Verdiana G. Masanja

Information spreading in a population can be modeled as an epidemic. Campaigners (e.g. election campaign managers, companies marketing products or movies) are interested in spreading a message by a given deadline, using limited resources.…

Systems and Control · Computer Science 2014-01-28 Kundan Kandhway , Joy Kuri

In this letter, we present a constraint-driven optimal control framework that achieves emergent cluster flocking within a constrained 2D environment. We formulate a decentralized optimal control problem that includes safety, flocking, and…

Optimization and Control · Mathematics 2022-03-22 Logan E. Beaver , Andreas A. Malikopoulos

We study the discrete-time dynamical systems associated to a stage-structured wild and sterile mosquito population. We describe all fixed points of the evolution operator (which depends on five parameters) of mosquito population and show…

Dynamical Systems · Mathematics 2020-02-28 Z. S. Boxonov , U. A. Rozikov

In this paper, we consider an optimal distributed control problem for a reaction-diffusion-based SIR epidemic model with human behavioral effects. We develop a model wherein non-pharmaceutical intervention methods are implemented, but a…

Analysis of PDEs · Mathematics 2025-02-11 Marcelo Bongarti , Christian Parkinson , Weinan Wang

This research introduces a new approach utilizing optimal control theory (OCT) to assess the Social Optimum (SO) of a vaccination game, navigating the intricate considerations of cost, availability, and distribution policies. By integrating…

Optimization and Control · Mathematics 2025-01-14 Md. Mamun-Ur-Rashid Khan , Jun Tanimoto

In this paper, we present a mathematical model for the interaction between honey bees and mites. The dynamics of a mite-infested honey bee colony and the evaluation of the commonly used mite-control strategies (traditional, mechanical and…

Populations and Evolution · Quantitative Biology 2022-05-26 A. Ssenoga , H. Ddumba , J. Y. T. Mugisha

Mass campaigns with antimalarial drugs are potentially a powerful tool for local elimination of malaria, yet current diagnostic technologies are insufficiently sensitive to identify all individuals who harbor infections. At the same time,…

Populations and Evolution · Quantitative Biology 2016-02-17 Jaline Gerardin , Caitlin A. Bever , Busiku Hamainza , John M. Miller , Philip A. Eckhoff , Edward A. Wenger

OBJECTIVE: To propose a new approach to analyze the age-distribution of reported cases for vector-transmitted infections. METHODS: Using officially reported number of cases of dengue, Zika, chikungunya, malaria and leishmaniasis for…

Populations and Evolution · Quantitative Biology 2026-03-18 Francisco Antonio Bezerra Coutinho , Marcos Amaku , Esper Georges Kallas , Eduardo Massad

Dengue is a mosquito-borne disease that threatens more than half of the world's population. Despite being endemic to over 100 countries, government-led efforts and mechanisms to timely identify and track the emergence of new infections are…

Applications · Statistics 2016-12-09 Shihao Yang , S. C. Kou , Fred Lu , John S. Brownstein , Nicholas Brooke , Mauricio Santillana

In this study, we develop and analyze a deterministic two-strain host-vector model for dengue transmission that incorporates key immuno-epidemiological mechanisms, including temporary cross-immunity, antibody-dependent enhancement (ADE),…

Dynamical Systems · Mathematics 2026-01-13 Burcu Gürbüz , Aytül Gökçe , Joseph Páez Chávez , Thomas Götz

Microbial pesticides can avoid many of negative effects of traditional chemical pesticides. To modelling the inhibiting effect, in this paper we propose a model of entomopathogenic nematodes killing the target insects, and inhibiting the…

Dynamical Systems · Mathematics 2022-09-13 Xiaoxiao Cui , Yonghui Xia
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