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Individualized treatment regimes (ITRs) aim to improve clinical outcomes by assigning treatment based on patient-specific characteristics. However, existing methods often struggle with high-dimensional covariates, limiting accuracy,…

Machine Learning · Statistics 2026-01-13 Sungtaek Son , Eardi Lila , Kwun Chuen Gary Chan

We propose a novel method, termed the M-learner, for estimating heterogeneous indirect and total treatment effects and identifying relevant subgroups within a mediation framework. The procedure comprises four key steps. First, we compute…

Machine Learning · Statistics 2025-08-14 Xingyu Li , Qing Liu , Tony Jiang , Hong Amy Xia , Brian P. Hobbs , Peng Wei

Decision support systems based on clinical notes have the potential to improve patient care by pointing doctors towards overseen risks. Predicting a patient's outcome is an essential part of such systems, for which the use of deep neural…

Computation and Language · Computer Science 2021-12-01 Betty van Aken , Sebastian Herrmann , Alexander Löser

Estimating heterogeneous treatment effects (HTEs) is crucial for precision medicine. While multiple studies can improve the generalizability of results, leveraging them for estimation is statistically challenging. Existing approaches often…

Methodology · Statistics 2025-12-22 Cathy Shyr , Boyu Ren , Prasad Patil , Giovanni Parmigiani

Implicit Neural Representations (INRs) have emerged as a paradigm in knowledge representation, offering exceptional flexibility and performance across a diverse range of applications. INRs leverage multilayer perceptrons (MLPs) to model…

Computer Vision and Pattern Recognition · Computer Science 2025-02-19 Amer Essakine , Yanqi Cheng , Chun-Wun Cheng , Lipei Zhang , Zhongying Deng , Lei Zhu , Carola-Bibiane Schönlieb , Angelica I Aviles-Rivero

Mental health disorders remain a significant challenge in modern healthcare, with diagnosis and treatment often relying on subjective patient descriptions and past medical history. To address this issue, we propose a personalized mental…

Machine Learning · Computer Science 2023-07-12 Manan Shukla , Oshani Seneviratne

This study investigates the identification of marginal treatment responses within multi-valued treatment models. Extending the hyper-rectangle model introduced by Lee and Salanie (2018), this paper relaxes restrictive assumptions, including…

Econometrics · Economics 2025-09-08 Xunkang Tian

Recent advances in remote health monitoring systems have significantly benefited patients and played a crucial role in improving their quality of life. However, while physiological health-focused solutions have demonstrated increasing…

Machine Learning · Computer Science 2023-03-28 Shayan Fazeli , Lionel Levine , Mehrab Beikzadeh , Baharan Mirzasoleiman , Bita Zadeh , Tara Peris , Majid Sarrafzadeh

Implicit neural representations (INRs) have gained prominence as a powerful paradigm in scene reconstruction and computer graphics, demonstrating remarkable results. By utilizing neural networks to parameterize data through implicit…

Image and Video Processing · Electrical Eng. & Systems 2023-08-01 Amirali Molaei , Amirhossein Aminimehr , Armin Tavakoli , Amirhossein Kazerouni , Bobby Azad , Reza Azad , Dorit Merhof

Multimodal (MM) learning is emerging as a promising paradigm in biomedical artificial intelligence (AI) applications, integrating complementary modality, which highlight different aspects of patient health. The scarcity of large…

Artificial Intelligence · Computer Science 2025-12-01 Niccolo Marini , Zhaohui Liang , Sivaramakrishnan Rajaraman , Zhiyun Xue , Sameer Antani

We regularly consider answering counterfactual questions in practice, such as "Would people with diabetes take a turn for the better had they choose another medication?". Observational studies are growing in significance in answering such…

Machine Learning · Computer Science 2022-08-16 Guanglin Zhou , Lina Yao , Xiwei Xu , Chen Wang , Liming Zhu

Multi-task learning (MTL) is useful for domains in which data originates from multiple sources that are individually under-sampled. MTL methods are able to learn classification models that have higher performance as compared to learning a…

Computer Vision and Pattern Recognition · Computer Science 2016-08-02 Bilal Ahmed , Thomas Thesen , Karen E. Blackmon , Ruben Kuzniecky , Orrin Devinsky , Jennifer G. Dy , Carla E. Brodley

Social media platforms provide valuable insights into mental health trends by capturing user-generated discussions on conditions such as depression, anxiety, and suicidal ideation. Machine learning (ML) and deep learning (DL) models have…

Computation and Language · Computer Science 2025-04-28 Zhanyi Ding , Zhongyan Wang , Yeyubei Zhang , Yuchen Cao , Yunchong Liu , Xiaorui Shen , Yexin Tian , Jianglai Dai

Estimating treatment effects conditional on observed covariates can improve the ability to tailor treatments to particular individuals. Doing so effectively requires dealing with potential confounding, and also enough data to adequately…

Recent advancements in the acquisition of various brain data sources have created new opportunities for integrating multimodal brain data to assist in early detection of complex brain disorders. However, current data integration approaches…

Image and Video Processing · Electrical Eng. & Systems 2023-05-26 Reza Shirkavand , Liang Zhan , Heng Huang , Li Shen , Paul M. Thompson

Randomized controlled trials typically analyze the effectiveness of treatments with the goal of making treatment recommendations for patient subgroups. With the advance of electronic health records, a great variety of data has been…

Machine Learning · Computer Science 2021-03-31 Zhiliang Wu , Yinchong Yang , Yunpu Ma , Yushan Liu , Rui Zhao , Michael Moor , Volker Tresp

Due to individual heterogeneity, performance gaps are observed between generic (one-size-fits-all) models and person-specific models in data-driven health applications. However, in real-world applications, generic models are usually more…

Machine Learning · Computer Science 2022-11-23 Zhaoyang Cao , Han Yu , Huiyuan Yang , Akane Sano

The modular structure of brain networks supports specialized information processing, complex dynamics, and cost-efficient spatial embedding. Inter-individual variation in modular structure has been linked to differences in performance,…

Inverse problems in imaging are typically ill-posed and are usually solved by employing regularized optimization techniques. The usage of appropriate constraints can restrict the solution space, thus making it feasible for a reconstruction…

Image and Video Processing · Electrical Eng. & Systems 2025-11-14 Jasleen Birdi , Tamal Majumder , Debanjan Halder , Muskan Kularia , Kedar Khare

Most efforts in interpretability in deep learning have focused on (1) extracting explanations of a specific downstream task in relation to the input features and (2) imposing constraints on the model, often at the expense of predictive…

Machine Learning · Computer Science 2022-02-22 Marco Bertolini , Djork-Arné Clevert , Floriane Montanari
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