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We consider the problem of two-sample testing in a semi-supervised setting with abundant unlabeled covariate data. Standard two-sample tests neglect covariate information, which has the potential to significantly boost performance. However,…

Machine Learning · Statistics 2026-05-05 Gyumin Lee , Shubhanshu Shekhar , Ilmun Kim

Motivated by the ongoing pandemic COVID-19, we propose a closed-loop framework that combines inference from testing data, learning the parameters of the dynamics and optimal resource allocation for controlling the spread of the…

Physics and Society · Physics 2021-04-27 Ashish R. Hota , Jaydeep Godbole , Philip E Paré

Using recent data from voluntary mass testing, I provide credible bounds on prevalence of SARS-CoV-2 for Austrian counties in early December 2020. When estimating prevalence, a natural missing data problem arises: no test results are…

General Economics · Economics 2020-12-23 Gabriel Ziegler

During an ongoing epidemic, especially in the case of a new agent, data are partial and sparse, also affected by external factors as for example climatic effects or preparedness and response capability of healthcare structures. Despite that…

Methodology · Statistics 2021-04-26 Filippo Carone Fabiani

The COVID-19 crisis highlighted the importance of non-medical interventions, such as testing and isolation of infected individuals, in the control of epidemics. Here, we show how to minimize testing needs while maintaining the number of…

Systems and Control · Electrical Eng. & Systems 2024-07-04 D. Acemoglu , A. Fallah , A. Giometto , D. Huttenlocher , A. Ozdaglar , F. Parise , S. Pattathil

We introduce a comprehensive screening platform for the COVID-19 (a.k.a., SARS-CoV-2) pneumonia. The proposed AI-based system works on chest x-ray (CXR) images to predict whether a patient is infected with the COVID-19 disease. Although the…

Pooled testing is widely used for screening for viral or bacterial infections with low prevalence when individual testing is not cost-efficient. Pooled testing with qualitative assays that give binary results has been well-studied. However,…

Methodology · Statistics 2020-11-03 Tao Liu , Joseph W Hogan , Wanning Su , Yizhen Xu , Michael J Daniels , Kantor Rami

Studies using assays to quantify the expression of thousands of genes on tens to thousands of cell samples have been carried out for over 20 years. Such assays are based on microarrays, DNA sequencing or other molecular technologies. All…

Statistics Theory · Mathematics 2025-06-18 Jiming Jiang , Johann A. Gagnon-Bartsch , Terence P. Speed

Without a cure, vaccine, or proven long-term immunity against SARS-CoV-2, test-trace-and-isolate (TTI) strategies present a promising tool to contain its spread. For any TTI strategy, however, mitigation is challenged by pre- and…

Crossover designs are an extremely useful tool to investigators, whilst group sequential methods have proven highly proficient at improving the efficiency of parallel group trials. Yet, group sequential methods and crossover designs have…

Methodology · Statistics 2017-10-11 Michael Grayling , James Wason , Adrian Mander

Testing individuals for pathogens can affect the spread of epidemics. Understanding how individual-level processes of sampling and reporting test results can affect community- or population-level spread is a dynamical modeling question. The…

Populations and Evolution · Quantitative Biology 2021-07-20 Ali Gharouni , F. M. Abdelmalek , David J. D. Earn , Jonathan Dushoff , Benjamin M. Bolker

The outbreak of the novel coronavirus (COVID-19) is unfolding as a major international crisis whose influence extends to every aspect of our daily lives. Effective testing allows infected individuals to be quarantined, thus reducing the…

Machine Learning · Computer Science 2020-07-28 Rahul Singh , Fang Liu , Ness B. Shroff

Among the challenges that the COVID-19 pandemic outbreak revealed is the problem to reduce the number of tests required for identifying the virus carriers in order to contain the viral spread while preserving the tests reliability. To cope…

Information Theory · Computer Science 2021-12-24 Catherine A. Haddad-Zaaknoon

Assuming that data are collected sequentially from independent streams, we consider the simultaneous testing of multiple binary hypotheses under two general setups; when the number of signals (correct alternatives) is known in advance, and…

Statistics Theory · Mathematics 2017-02-14 Yanglei Song , Georgios Fellouris

The first part of the paper presents a review of the gold-standard testing protocol for Covid-19, real-time, reverse transcriptase PCR, and its properties and associated measurement data such as amplification curves that can guide the…

Quantitative Methods · Quantitative Biology 2021-06-08 Ryan Gabrys , Srilakshmi Pattabiraman , Vishal Rana , João Ribeiro , Mahdi Cheraghchi , Venkatesan Guruswami , Olgica Milenkovic

Long-term care facilities have been widely affected by the COVID-19 pandemic. Retirement homes are particularly vulnerable due to the higher mortality risk of infected elderly individuals. Once an outbreak occurs, suppressing the spread of…

Optimization and Control · Mathematics 2022-04-06 Mansoor Davoodi , Ana Batista , Abhishek Senapati , Weronika Schlechte-Welnicz , Birgit Wagner , Justin M. Calabrese

This paper is a short extension of our previous paper [arXiv:2004.06033] about the use of the Test-Negative design to study risk factors for COVID-19 [See: PubMed and ArXiv reference below] Reason for the extension is that the conditions…

Populations and Evolution · Quantitative Biology 2021-06-08 Jan P Vandenbroucke , Elizabeth B Brickley , Christina M. J. E. Vandenbroucke-Grauls , Neil Pearce

Currently, the world seeks to find appropriate mitigation techniques to control and prevent the spread of the new SARS-CoV-2. In our paper herein, we present a peculiar Multi-Task Learning framework that jointly predicts the effect of…

Machine Learning · Computer Science 2021-08-24 Bonaventure Chidube Molokwu , Shaon Bhatta Shuvo , Ziad Kobti , Anne Snowdon

The fundamental task of group testing is to recover a small distinguished subset of items from a large population while efficiently reducing the total number of tests (measurements). The key contribution of this paper is in adopting a new…

Information Theory · Computer Science 2015-03-13 George Kamal Atia , Venkatesh Saligrama

During the SARS-CoV-2 pandemic, polymerase chain reaction (PCR) and lateral flow device (LFD) tests were frequently deployed to detect the presence of SARS-CoV-2. Many of these tests were singleplex, and only tested for the presence of a…

Applications · Statistics 2024-09-02 Martyn Fyles , Christopher E. Overton , Tom Ward , Emma Bennett , Tom Fowler , Ian Hall