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Biological and biomedical samples are routinely examined using focused two-photon (2P) fluorescence microscopy due to its intrinsic axial sectioning and reduced out-of-focus bleaching. However, 2P imaging often requires excitation…

We demonstrate fast counting and multiphoton detection abilities of a Silicon Photo Multiplier (SiPM). In fast counting mode we are able to detect two consecutive photons separated by only 2.3 ns corresponding to 430 MHz. The counting…

Quantum Physics · Physics 2009-11-13 P. Eraerds , M. Legre , A. Rochas , H. Zbinden , N. Gisin

We report the cell biological applications of a recently developed multiphoton fluorescence lifetime imaging microscopy system using a streak camera (StreakFLIM). The system was calibrated with standard fluorophore specimens and was shown…

Cell Behavior · Quantitative Biology 2009-11-10 R. V. Krishnan , Eva Biener , Jian-Hua Zhang , Robert Heckel , Brian Herman

Two-color lasers with high coherence are paramount in precision measurement, accurate light-matter interaction, and low-noise photonic microwave generation. However, conventional two-color lasers often suffer from low coherence,…

Holographic multimode fibre endoscopes have recently shown their ability to unveil and monitor deep brain structures with sub-micrometre resolution, establishing themselves as a minimally-invasive technology with promising applications in…

Ultra-fast and multi-dimensional spectroscopy gives a powerful looking glass into the dynamics of molecular systems. In particular two-dimensional electronic spectroscopy (2DES) provides a probe of coherence and the flow of energy within…

Quantum Physics · Physics 2021-03-31 André Anda , Jared H. Cole

Optical micro-spectroscopy is an invaluable tool for studying and characterizing samples ranging from classical semiconductors to low-dimensional materials and heterostructures. To date, most implementations are based on point-scanning…

Super-resolution fluorescence microscopy is of great interest in life science studies for visualizing subcellular structures at the nanometer scale. Among various kinds of super-resolution approaches, image scanning microscopy (ISM) offers…

Hong-Ou-Mandel (HOM) interference is a quantum optics laboratory experiment that has recently become more accessible to undergraduate students. The experiment consists of two identical photons simultaneously entering a non-polarizing beam…

Physics Education · Physics 2024-09-06 Cyrus Bjurlin , Theresa Chmiel

Silicon photomultipliers (SiPMs) have a few advantages over conventional photomultiplier tubes (PMTs) used in imaging atmospheric Cherenkov telescopes. The first notable characteristic is their higher photon detection efficiency (PDE) of up…

Instrumentation and Methods for Astrophysics · Physics 2023-09-19 Akira Okumura , Junya Haga , Chiaki Inoue , Keiji Nishimoto , Kazuhiro Furuta , Hiroyasu Tajima

Characterizing and controlling electronic properties of quantum materials require direct measurements of non-equilibrium electronic band structures over large regions of momentum space. Here, we demonstrate an experimental apparatus for…

The progress of designing organic semiconductors is extensively dependent on the quality of prepared organic molecular assemblies, since the charge transport mechanism is strongly efficient in highly ordered crystals compared to amorphous…

Materials Science · Physics 2025-10-07 Moha Naeimi , Katharina Engster , Waqas Pervez , Ingo Barke , Sylvia Speller

Recent developments in integrated optics have made it possible to fabricate high-bandwidth electro-optic modulators (EOMs). Here we show cascaded operation of two of such modulators driven by custom-built electronics delivering on-demand…

A silicon photomultiplier (SiPM) array has been developed at FBK-irst having 32 channels and a dimension of 8.0 x 1.1 mm^2. Each 250 um wide channel is subdivided into 5 x 22 rectangularly arranged pixels. These sensors are developed to…

Instrumentation and Detectors · Physics 2010-03-04 R. Greim , H. Gast , T. Kirn , J. Olzem , G. Roper Yearwood , S. Schael , N. Zimmermann , G. Ambrosi , P. Azzarello , R. Battiston , C. Piemonte

A single-pixel digital holography system with phase-encoded illumination using a digital micromirror device (DMD) as a spatial light modulator (SLM) is presented. The enhanced switching rate of DMDs, far exceeding the stringent frame-rate…

Microscopy is an essential tool in scientific research, enabling the visualization of structures at micro- and nanoscale resolutions. However, the field of microscopy often encounters limitations in field-of-view (FOV), restricting the…

Image and Video Processing · Electrical Eng. & Systems 2025-03-17 Huanhuan Zhao , Ruben Millan-Solsona , Marti Checa , Spenser R. Brown , Jennifer L. Morrell-Falvey , Liam Collins , Arpan Biswas

Histochemical staining is essential for visualizing tissue architecture and cellular morphology but is destructive and limited by the availability of tissue for multiple stains. Virtual staining with label-free microscopy offers a…

In this paper, we review and compare HPM sources operating without a magnetic field to guide the electron beam that are capable of producing high-power microwave (HPM) pulses with a duration of about 100 ns. The proposed analysis summarizes…

Accelerator Physics · Physics 2022-11-11 S. Anishchenko , V. Baryshevsky , A. Gurinovich , E. Gurnevich , P. Molchanov , A. Rouba

Time-of-flight (ToF) 3D imaging has a wealth of applications, from industrial inspection to movement tracking and gesture recognition. Depth information is recovered by measuring the round-trip flight time of laser pulses, which usually…

High-speed signal processing is essential for maximizing data throughput in emerging communication applications, like multiple-input multiple-output (MIMO) systems and radio-frequency (RF) interference cancellation. However, as these…