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Human pose estimation on medium and small scales has long been a significant challenge in this field. Most existing methods focus on restoring high-resolution feature maps by stacking multiple costly deconvolutional layers or by…
Fluorescence imaging is the most widely used method for unveiling the molecular composition of biological specimens. However, the weak optical emission of fluorescent probes and the tradeoff between imaging speed and sensitivity is…
We demonstrate an electro-optic wide-field method to enable fluorescence lifetime microscopy (FLIM) with high throughput and single-molecule sensitivity. Resonantly driven Pockels cells are used to efficiently gate images at 39 MHz,…
We introduce an efficient and accurate alternative to full hydrodynamic simulations, Hydro-PM (HPM), for the study of the low column density Lyman-alpha forest. It consists of a Particle-Mesh solver, modified to compute, in addition to the…
High-energy, few-cycle laser pulses are essential for numerous applications in the fields of ultrafast optics and strong-field physics, due to their ultrafast temporal resolution and high peak intensity. In this work, different from the…
We present a new approach for electronic control of optical tweezers by using space-time-wavelength mapping (STWM), a technique that uses time-domain modulation to control local intensity values, and hence the resulting optical force, in…
Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical…
Many of the characteristics of Silicon Photomultipliers (SiPMs), such as high Photon Detection Efficiency (PDE), are well matched to the requirements of the cameras of the Small-Sized Telescopes (SSTs) proposed for the Cherenkov Telescope…
Attosecond light sources based on high-order harmonic generation (HHG) constitute to date the only table-top solution for producing coherent broadband radiation covering the spectral range from the extreme ultraviolet to the soft X-rays.…
The current standard for detecting human epidermal growth factor receptor 2 (HER2) status in breast cancer patients relies on HER2 amplification, identified through fluorescence in situ hybridization (FISH) or immunohistochemistry (IHC).…
Ising machines are emerging as a powerful physical alternative to digital processors for solving combinatorial optimization problems. Among them, spatial photonic Ising machines (SPIMs) offer compact, room-temperature hardware with…
Image enhancement aims at processing an input image so that the visual content of the output image is more pleasing or more useful for certain applications. Although histogram equalization is widely used in image enhancement due to its…
In the past decades, absorption modalities have emerged as powerful tools for label-free functional and structural imaging of cells and tissues. Many biomolecules present unique absorption spectra providing chromophore-specific information…
Photonic integrated circuits provide a compact platform for ultrafast and energy-efficient matrix-vector multiplications (MVMs) in the optical domain. Recently, schemes based on time-division multiplexing (TDM) have been proposed as…
We describe the design, operation, and performance of a new high-speed infrared photometer using the Solid-State Photomultiplier (SSPM) detector. The SSPM was developed by Rockwell International Science Center and has single-photon counting…
Label-Free Multiphoton Microscopy is a very powerful optical microscopy that can be applied to study samples with no need for exogenous fluorescent probes, keeping the main benefits of a Multiphoton approach, like longer penetration depths…
We demonstrate, for the first time, the application of rare-gas filled hollow-core photonic crystal fibres (HC-PCFs) as tuneable ultraviolet light sources in femtosecond pump-probe spectroscopy. The time-resolved photoelectron imaging…
The rapid development of digital pathology and modern deep learning has facilitated the emergence of pathology foundation models that are expected to solve general pathology problems under various disease conditions in one unified model,…
Beam shaping - the ability to engineer the phase and the amplitude of massive and massless particles - has long interested scientists working on communication, imaging and the foundations of quantum mechanics. In light optics, the shaping…
The different algorithms appropriate for point source photometry on data from the SPIRE instrument on-board the Herschel Space Observatory, within the Herschel Interactive Processing Environment (HIPE) are compared. Point source photometry…