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Deep Neural Network (DNN) inference is emerging as the fundamental bedrock for a multitude of utilities and services. CPUs continue to scale up their raw compute capabilities for DNN inference along with mature high performance libraries to…

Due to reduced manufacturing yields, traditional monolithic chips cannot keep up with the compute, memory, and communication demands of data-intensive applications, such as rapidly growing deep neural network (DNN) models. Chiplet-based…

Hardware Architecture · Computer Science 2025-10-31 Lukas Pfromm , Alish Kanani , Harsh Sharma , Janardhan Rao Doppa , Partha Pratim Pande , Umit Y. Ogras

Genome sequence analysis plays a pivotal role in enabling many medical and scientific advancements in personalized medicine, outbreak tracing, and forensics. However, the analysis of genome sequencing data is currently bottlenecked by the…

Hardware Architecture · Computer Science 2021-11-04 Damla Senol Cali

Raw nanopore signal analysis is a common approach in genomics to provide fast and resource-efficient analysis without translating the signals to bases (i.e., without basecalling). However, existing solutions cannot interpret raw signals…

Large Language Model (LLM) inference requires substantial computational resources, yet CPU-based inference remains essential for democratizing AI due to the widespread availability of CPUs compared to specialized accelerators. However,…

Hardware Architecture · Computer Science 2025-10-01 Jingyao Zhang , Jaewoo Park , Jongeun Lee , Elaheh Sadredini

Basecalling, an essential step in many genome analysis studies, relies on large Deep Neural Networks (DNNs) to achieve high accuracy. Unfortunately, these DNNs are computationally slow and inefficient, leading to considerable delays and…

Hardware Architecture · Computer Science 2023-11-28 Taha Shahroodi , Gagandeep Singh , Mahdi Zahedi , Haiyu Mao , Joel Lindegger , Can Firtina , Stephan Wong , Onur Mutlu , Said Hamdioui

DNA sequencing is the physical/biochemical process of identifying the location of the four bases (Adenine, Guanine, Cytosine, Thymine) in a DNA strand. As semiconductor technology revolutionized computing, modern DNA sequencing technology…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-05-06 S. Karen Khatamifard , Zamshed Chowdhury , Nakul Pande , Meisam Razaviyayn , Chris Kim , Ulya R. Karpuzcu

DNA data storage is rapidly emerging as a promising solution for long-term data archiving, largely due to its exceptional durability. However, the synthesis of DNA strands remains a significant bottleneck in terms of cost and speed. To…

Other Computer Science · Computer Science 2025-07-11 Parv Agarwal , Nimesh Pinnamaneni , Thomas Heinis

The widespread adoption of cloud-based solutions introduces privacy and security concerns. Techniques such as homomorphic encryption (HE) mitigate this problem by allowing computation over encrypted data without the need for decryption.…

Cryptography and Security · Computer Science 2024-12-13 Mpoki Mwaisela , Joel Hari , Peterson Yuhala , Jämes Ménétrey , Pascal Felber , Valerio Schiavoni

DNNs are widely used but face significant computational costs due to matrix multiplications, especially from data movement between the memory and processing units. One promising approach is therefore Processing-in-Memory as it greatly…

Hardware Architecture · Computer Science 2024-01-19 Lorenzo Sonnino , Shaswot Shresthamali , Yuan He , Masaaki Kondo

With the rapid growth of deep neural networks (DNNs), compute-in-memory (CIM) has emerged as a promising energy-efficient paradigm for accelerating multiply-and-accumulate (MAC) operations. Yet, current CIM architectures are largely limited…

Hardware Architecture · Computer Science 2026-04-16 Subhradip Chakraborty , Ankur Singh , Akhilesh R. Jaiswal

Processing in-memory (PIM) is promising to accelerate neural networks (NNs) because it minimizes data movement and provides large computational parallelism. Similar to machine learning accelerators, application mapping, which determines the…

Hardware Architecture · Computer Science 2024-07-02 Xuan Wang , Minxuan Zhou , Tajana Rosing

Dynamic programming (DP) algorithms, such as All-Pairs Shortest Path (APSP) and genomic sequence alignment, are fundamental to many scientific domains but are severely bottlenecked by data movement on conventional architectures. While…

Hardware Architecture · Computer Science 2026-03-02 Tsung-Han Lu , Weihong Xu , Tajana Rosing

As DNNs are widely adopted in various application domains while demanding increasingly higher compute and memory requirements, designing efficient and performant NPUs (Neural Processing Units) is becoming more important. However, existing…

Hardware Architecture · Computer Science 2024-06-13 Hyungkyu Ham , Wonhyuk Yang , Yunseon Shin , Okkyun Woo , Guseul Heo , Sangyeop Lee , Jongse Park , Gwangsun Kim

The 3D point cloud perception has emerged as a fundamental role for a wide range of applications. In particular, with the rapid development of neural networks, the voxel-based networks attract great attention due to their excellent…

Hardware Architecture · Computer Science 2024-10-01 Xipeng Lin , Shanshi Huang , Hongwu Jiang

Edge computing must be capable of executing computationally intensive algorithms, such as Deep Neural Networks (DNNs) while operating within a constrained computational resource budget. Such computations involve Matrix Vector…

Hardware Architecture · Computer Science 2023-10-24 Arani Roy , Kaushik Roy

Processing-in-memory (PIM) has emerged as an enabler for the energy-efficient and high-performance acceleration of deep learning (DL) workloads. Resistive random-access memory (ReRAM) is one of the most promising technologies to implement…

Hardware Architecture · Computer Science 2024-03-29 Harsh Sharma , Gaurav Narang , Janardhan Rao Doppa , Umit Ogras , Partha Pratim Pande

Resistive Random Access Memory (ReRAM) based Processing In Memory (PIM) Accelerator has emerged as a promising computing architecture for memory intensive applications, such as Deep Neural Networks (DNNs). However, due to its immaturity,…

Emerging Technologies · Computer Science 2023-12-19 Je-Woo Jang , Thai-Hoang Nguyen , Joon-Sung Yang

Although deep learning-based personalized recommendation systems provide qualified recommendations, they strain data center resources. The main bottleneck is the embedding layer, which is highly memory-intensive due to its sparse, irregular…

Hardware Architecture · Computer Science 2025-11-26 Youngsuk Kim , Junghwan Lim , Hyuk-Jae Lee , Chae Eun Rhee

Analog processing-using-memory (PUM; a.k.a. in-memory computing) makes use of electrical interactions inside memory arrays to perform bulk matrix-vector multiplication (MVM) operations. However, many popular matrix-based kernels need to…

Hardware Architecture · Computer Science 2026-05-06 Ryan Wong , Ben Feinberg , Saugata Ghose