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We extend the classical SIR model of infectious disease spread to account for time dependence in the parameters, which also include diffusivities. The temporal dependence accounts for the changing characteristics of testing, quarantine and…

Populations and Evolution · Quantitative Biology 2020-07-03 Zhenlin Wang , Xiaoxuan Zhang , Gregory Teichert , Mariana Carrasco-Teja , Krishna Garikipati

When an infection spreads in a community, an individual's probability of becoming infected depends on both her susceptibility and exposure to the contagion through contact with others. While one often has knowledge regarding an individual's…

Social and Information Networks · Computer Science 2017-12-05 Maggie Makar , John Guttag , Jenna Wiens

We recently described a dynamic causal model of a COVID-19 outbreak within a single region. Here, we combine several of these (epidemic) models to create a (pandemic) model of viral spread among regions. Our focus is on a second wave of new…

COVID-19 vaccines are highly efficacious at preventing symptomatic infection, severe disease, and death. Most of the evidence that COVID-19 vaccines also reduce transmission of SARS-CoV-2 is based on retrospective, observational studies.…

Applications · Statistics 2022-06-16 Marlena S. Bannick , Fei Gao , Elizabeth R. Brown , Holly E. Janes

We investigate how the properties of epidemic networks change depending on the availability of different types of data on a disease outbreak. This is achieved by introducing mathematical and computational methods that estimate the…

Computational Physics · Physics 2025-09-03 Oscar Fajardo-Fontiveros , Carl J. E. Suster , Eduardo G. Altmann

During the COVID-19 pandemic, the behavioral response to reported case numbers changed drastically over time. While a few dozen cases were enough to trigger government-induced and voluntary contact reduction in early 2020, less than a year…

Physics and Society · Physics 2023-09-27 Bastian Heinlein , Manlio De Domenico

The coronavirus disease 2019 (COVID-19) pandemic radically impacts our lives, while the transmission/infection and recovery dynamics of COVID-19 remain obscure. A time-dependent Susceptible, Exposed, Infectious, and Recovered (SEIR) model…

Populations and Evolution · Quantitative Biology 2020-04-01 Yong Zhang , Xiangnan Yu , HongGuang Sun , Geoffrey R. Tick , Wei Wei , Bin Jin

Individuals infected with SARS-CoV-2, the virus that causes COVID-19, may shed the virus in stool before developing symptoms, suggesting that measurements of SARS-CoV-2 concentrations in wastewater could be a "leading indicator" of COVID-19…

Other Quantitative Biology · Quantitative Biology 2021-06-25 Scott W. Olesen , Maxim Imakaev , Claire Duvallet

More than any other infectious disease epidemic, the COVID-19 pandemic has been characterized by the generation of large volumes of viral genomic data at an incredible pace due to recent advances in high-throughput sequencing technologies,…

Objective: To conduct a meta-analysis of current studies that examined sex differences in severity and mortality in patients with COVID-19, and identify potential mechanisms underpinning these differences. Methods: We performed a systematic…

Populations and Evolution · Quantitative Biology 2020-03-31 Xiyi Wei , Yu-Tian Xiao , Jian Wang , Rui Chen , Wei Zhang , Yue Yang , Daojun Lv , Chao Qin , Di Gu , Bo Zhang , Weidong Chen , Jianquan Hou , Ninghong Song , Guohua Zeng , Shancheng Ren

Identifying the relative importance of the different transmission routes of the SARS-CoV-2 virus is an urgent research priority. To that end, the different transmission routes, and their role in determining the evolution of the Covid-19…

Populations and Evolution · Quantitative Biology 2020-12-08 Swetaprovo Chaudhuri , Saptarshi Basu , Abhishek Saha

In this paper, we develop an extension of standard epidemiological models, suitable for COVID-19. This extension incorporates the transmission due to pre-symptomatic or asymptomatic carriers of the virus. Furthermore, this model also…

Populations and Evolution · Quantitative Biology 2020-11-20 Anirban Ghatak , Shivshanker Singh Patel , Soham Bonnerjee , Subhrajyoty Roy

After more than 6 million deaths worldwide, the ongoing vaccination to conquer the COVID-19 disease is now competing with the emergence of increasingly contagious mutations, repeatedly supplanting earlier strains. Following the near-absence…

Populations and Evolution · Quantitative Biology 2022-05-09 Fabian Jan Schwarzendahl , Jens Grauer , Benno Liebchen , Hartmut Löwen

Diffusion comes anytime and everywhere. If there is a gradient or a potential difference of a quantity a diffusion process happens and this ends if an equilibrium is reached only. The concentration of a species maybe such quantity, or the…

Physics and Society · Physics 2021-02-02 Guenter Bärwolff

In the first part of this paper, we review old and new results about the influence of host population heterogeneity on (various characteristics of) epidemic outbreaks. In the second part we highlight a modelling issue that so far has…

Populations and Evolution · Quantitative Biology 2024-01-17 Martin Bootsma , Danny Chan , Odo Diekmann , Hisashi Inaba

The dynamics of epidemics depend on how people's behavior changes during an outbreak. At the beginning of the epidemic, people do not know about the virus, then, after the outbreak of epidemics and alarm, they begin to comply with the…

Physics and Society · Physics 2021-11-29 I. A. Kastalskiy , E. V. Pankratova , E. M. Mirkes , V. B. Kazantsev , A. N. Gorban

The infections and fatalities due to SARS-CoV-2 virus for cases specific to India have been studied using a deterministic susceptible-exposed-infected-recovered-dead (SEIRD) compartmental model. One of the most significant epidemiological…

Populations and Evolution · Quantitative Biology 2020-06-09 Vishwajeet Jha

Since 1927, until recently, models describing the spread of disease have mostly been of the SIR-compartmental type, based on the assumption that populations are homogeneous and well-mixed. The focus of these models have typically been on…

Physics and Society · Physics 2014-07-23 Lara Goscé , David A W Barton , Anders Johansson

Modeling epidemic dynamics plays an important role in studying how diseases spread, predicting their future course, and designing strategies to control them. In this letter, we introduce a model of SIR (susceptible-infected-removed) type…

Populations and Evolution · Quantitative Biology 2013-12-17 Li Chen , Fakhteh Ghanbarnejad , Weiran Cai , Peter Grassberger

Pandemics can cause immense disruption and damage to communities and societies. Thus far, modeling of pandemics has focused on either large-scale difference equation models like the SIR and the SEIR models, or detailed micro-level…

Multiagent Systems · Computer Science 2010-07-27 Teruhiko Yoneyama , Sanmay Das , Mukkai Krishnamoorthy