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We investigate the spread of diseases, computer viruses or information on complex networks and also immunization strategies to prevent or control the spread. When an entire population cannot be immunized and the effect of immunization is…

Physics and Society · Physics 2011-04-14 Shinji Tanimoto

Clinical trials of a vaccine during an epidemic face particular challenges, such as the pressure to identify an effective vaccine quickly to control the epidemic, and the effect that time-space-varying infection incidence has on the power…

Populations and Evolution · Quantitative Biology 2021-05-21 Rob Johnson , Chris Jackson , Anne Presanis , Sofia S. Villar , Daniela De Angelis

Understanding how the network topology affects the spread of an epidemic is a main concern in order to develop efficient immunization strategies. While there is a great deal of work dealing with the macroscopic topological properties of the…

Social and Information Networks · Computer Science 2023-01-02 Debayan Chakraborty , Anurag Singh , Hocine Cherifi

Effective strategies of vaccine prioritization are essential to mitigate the impacts of severe infectious diseases. We investigate the role of infection fatality ratio (IFR) and social contact matrices on vaccination prioritization using a…

Populations and Evolution · Quantitative Biology 2023-10-04 Arthur Schulenburg , Wesley Cota , Guilherme S. Costa , Silvio C. Ferreira

The review article aims to provide an overview of the challenges and strategies for enhancing interoperability among health information systems in low- and middle- income countries (LMICs). Achieving interoperability in LMICs presents…

Computers and Society · Computer Science 2023-09-25 Prabath Jayathissa , Roshan Hewapathirana

Background: Despite the consensus that vaccines play an important role in combating the global spread of infectious diseases, vaccine inequity is still rampant with deep-seated mentality of self-priority. This study aims to evaluate the…

Populations and Evolution · Quantitative Biology 2023-10-16 Zhenyu Han , Qianyue Hao , Qiwei He , Katherine Budeski , Depeng Jin , Fengli Xu , Kun Tang

A persistent public health challenge is finding immunization schemes that are effective in combating highly mutable pathogens such as HIV and influenza viruses. To address this, we analyze a simplified model of affinity maturation, the…

Populations and Evolution · Quantitative Biology 2024-04-25 Saeed Mahdisoltani , Pranav Murugan , Arup K Chakraborty , Mehran Kardar

Vaccination is essential for the management of infectious diseases, many of which continue to pose devastating public health and economic challenges across the world. However, many vaccines are imperfect having only a partial protective…

Populations and Evolution · Quantitative Biology 2022-08-04 Hetsron L. Nyandjo-Bamen , Jean Marie Ntaganda , Aurelien Tellier , Olivier Menoukeu-Pamen

Massive vaccination against pandemics such as Coronavirus SARS-CoV-2 presents several complexities. The criteria to assess public health policies are fundamental to distribute vaccines in an effective way in order to avoid as many…

Optimization and Control · Mathematics 2023-12-01 José Luis Sainz-Pardo , José Valero

We propose a mathematical framework, based on conic geometric programming, to control a susceptible-infected-susceptible viral spreading process taking place in a directed contact network with unknown contact rates. We assume that we have…

Optimization and Control · Mathematics 2014-12-09 Shuo Han , Victor M. Preciado , Cameron Nowzari , George J. Pappas

While conducting probabilistic surveys is the gold standard for assessing vaccine coverage, implementing these surveys poses challenges for global health. There is a need for more convenient option that is more affordable and practical.…

Applications · Statistics 2026-03-30 Nathaniel Dyrkton , Shomoita Alam , Susan Shepherd , Ibrahim Sana , Kevin Phelan , Jay JH Park

The resurgence of measles is largely attributed to the decline in vaccine adoption and the increase in mobility. Although the vaccine for measles is readily available and highly successful, its current adoption is not adequate to prevent…

Populations and Evolution · Quantitative Biology 2020-08-26 Sheryl L. Chang , Mahendra Piraveenan , Mikhail Prokopenko

This paper studies an optimal control problem for a class of SIR epidemic models, in scenarios in which the infected population is constrained to be lower than a critical threshold imposed by the ICU (intensive care unit) capacity. The…

Optimization and Control · Mathematics 2024-12-31 Matteo Della Rossa , Lorenzo Freddi , Dan Goreac

To mitigate the impact of the pandemic, several measures include lockdowns, rapid vaccination programs, school closures, and economic stimulus. These interventions can have positive or unintended negative consequences. Current research to…

Machine Learning · Computer Science 2025-08-11 Gaurav Deshkar , Jayanta Kshirsagar , Harshal Hayatnagarkar , Janani Venugopalan

We consider the problem of optimizing locations of distribution centers (DCs) and plans for distributing resources such as test kits and vaccines, under spatiotemporal uncertainties of disease spread and demand for the resources. We aim to…

Optimization and Control · Mathematics 2022-07-19 Beste Basciftci , Xian Yu , Siqian Shen

How to prevent the spread of human diseases is a great challenge for the scientific community and so far there are many studies in which immunization strategies have been developed. However, these kind of strategies usually do not consider…

Physics and Society · Physics 2018-08-22 M. A. Di Muro , L. G. Alvarez-Zuzek , S. Havlin , L. A. Braunstein

The limited availability of COVID-19 vaccines has prompted extensive research on optimal vaccination strategies. Previous studies have considered various non-pharmaceutical interventions, vaccine efficacy, and distribution strategies. In…

Populations and Evolution · Quantitative Biology 2025-02-27 Iker Atienza-Diez , Gabriel Rodriguez-Maroto , Saúl Ares , Susanna Manrubia

We propose a framework for the description of the effects of vaccinations on the spreading of an epidemic disease. Different vaccines can be dosed, each providing different immunization times and immunization levels. Differences due to…

Analysis of PDEs · Mathematics 2024-07-23 Rinaldo M. Colombo , Mauro Garavello

We consider online resource allocation under a typical non-profit setting, where limited or even scarce resources are administered by a not-for-profit organization like a government. We focus on the internal-equity by assuming that arriving…

Computer Science and Game Theory · Computer Science 2021-12-10 Pan Xu , Yifan Xu

Although community structure is ubiquitous in complex networks, few works exploit this topological property to control epidemics. In this work, devoted to networks with non-overlapping community structure (i.e, a node belongs to a single…

Social and Information Networks · Computer Science 2018-06-15 Zakariya Ghalmane , Mohammed El Hassouni , Hocine Cherifi