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We analyze an optimal control version of a simple SIR epidemiology model that includes a partially specified vaccination policy and takes into account fatigue from protracted application of social distancing measures. The model assumes…

Populations and Evolution · Quantitative Biology 2021-08-17 Evangelos F. Magirou

In many real-world complex systems, individuals have many kind of interactions among them, suggesting that it is necessary to consider a layered structure framework to model systems such as social interactions. This structure can be…

Physics and Society · Physics 2015-02-06 C. Buono , L. A. Braunstein

Multi-model prediction efforts in infectious disease modeling and climate modeling involve multiple teams independently producing projections under various scenarios. Often these scenarios are produced by the presence and absence of a…

Methodology · Statistics 2022-08-11 Yuanhao Lu , Ajitesh Srivastava

There are often multiple diseases with cross immunity competing for vaccination resources. Here we investigate the optimal vaccination program in a two-layer Susceptible-Infected-Removed (SIR) model, where two diseases with cross immunity…

Populations and Evolution · Quantitative Biology 2021-05-26 Yang Ye , Qingpeng Zhang , Zhidong Cao , Daniel Dajun Zeng

The global SARS-CoV-2 (COVID-19) pandemic highlighted the challenge of equitable vaccine distribution between high- and low-income countries. Many high-income countries were reluctant or slow to distribute extra doses of the vaccine to…

Populations and Evolution · Quantitative Biology 2024-08-21 Abraham Holleran , Susan E. Martonosi , Michael Veatch

Motivated by the increasing number of COVID-19 cases that have been observed in many countries after the vaccination and relaxation of non-pharmaceutical interventions, we propose a mathematical model on time-varying networks for the spread…

Dynamical Systems · Mathematics 2022-03-09 Kathinka Frieswijk , Lorenzo Zino , Ming Cao

How to strategically allocate the available vaccines is a crucial issue for pandemic control. In this work, we propose a mathematical framework for optimal stabilizing vaccine allocation, where our goal is to send the infections to zero as…

Optimization and Control · Mathematics 2021-09-13 Qianqian Ma , Yang-Yu Liu , Alex Olshevsky

We estimate patterns of covariation between COVID-19 vaccination rates and a set of widely used indicators of human, social, and economic capital across 146 countries in July 2021 and February 2022. About 70% of the variability in COVID-19…

Physics and Society · Physics 2022-03-02 Cosima Rughinis , Simona-Nicoleta Vulpe , Michael G. Flaherty , Sorina Vasile

In the era of a growing population, systemic changes to the world, and the rising risk of crises, humanity has been facing an unprecedented challenge of resource scarcity. Confronting and addressing the issues concerning the scarce…

Theoretical Economics · Economics 2022-11-23 Xiaowei Hu , Peng Li

The threat of avian influenza and the 2004-2005 influenza vaccine supply shortage in the United States has sparked a debate about optimal vaccination strategies to reduce the burden of morbidity and mortality caused by the influenza virus.…

Populations and Evolution · Quantitative Biology 2010-02-10 Shweta Bansal , Babak Pourbohloul , Lauren Ancel Meyers

Vaccine delivery in under-resourced locations with security risks is not just challenging but also life threatening. The current COVID pandemic and the need to vaccinate have added even more urgency to this issue. Motivated by this problem,…

Computer Science and Game Theory · Computer Science 2022-04-26 Tien Mai , Arunesh Sinha

Chance-constrained programming (CCP) is one of the most difficult classes of optimization problems that has attracted the attention of researchers since the 1950s. In this survey, we focus on cases when only a limited information on the…

Optimization and Control · Mathematics 2022-02-15 Simge Küçükyavuz , Ruiwei Jiang

In this paper, we introduce an algorithm designed to solve a Multilevel MOnoObjective Linear Programming Problem (ML(MO)OLPP). Our approach is a refined adaptation of Sinha and Sinha's linear programming method, incorporating the…

Optimization and Control · Mathematics 2025-03-17 Mustapha Kaci

Infectious diseases are still a major global burden for modern society causing 13 million deaths annually. One way to reduce the morbidity and mortality rates from infectious diseases is through preventative or targeted vaccinations.…

Social and Information Networks · Computer Science 2021-01-27 Md Shahzamal , Raja Jurdak , Bernard Mans , Frank de Hoog , Dean Paini

Simulations of infectious disease spread have long been used to understand how epidemics evolve and how to effectively treat them. However, comparatively little attention has been paid to understanding the fairness implications of different…

Social and Information Networks · Computer Science 2019-11-14 James Atwood , Hansa Srinivasan , Yoni Halpern , D Sculley

The waning of immunity after recovery or vaccination is a major factor accounting for the severity and prolonged duration of an array of epidemics, ranging from COVID-19 to diphtheria and pertussis. To study the effectiveness of different…

Dynamical Systems · Mathematics 2023-02-01 Shoshana Elgart

The impact of information dissemination on epidemic control is essentially subject to individual behaviors. Unlike information-driven behaviors, vaccination is determined by many cost-related factors, whose correlation with the information…

Physics and Society · Physics 2019-04-03 Xiao-Jie Li , Cong Li , Xiang Li

We study in a general mathematical framework the optimal allocation of vaccine in an heterogeneous population. We cast the problem of optimal vaccination as a bi-objective minimization problem min(C($\eta$),L($\eta$)), where C and L stand…

Optimization and Control · Mathematics 2025-03-21 Jean-François Delmas , Dylan Dronnier , Pierre-André Zitt

The outbreak of mutant strains and vaccination behaviors have been the focus of recent epidemiological research, but most existing epidemic models failed to simultaneously capture viral mutation and consider the complexity and behavioral…

Populations and Evolution · Quantitative Biology 2026-01-16 Wenjie Zhang , Yusheng Li , Qin Li , Guojun Huang , Minyu Feng

Information dissemination intricately intertwines with the dynamics of infectious diseases in the contemporary interconnected world. Recognizing the critical role of public awareness, individual vaccination choices appear to be an essential…

Physics and Society · Physics 2024-10-30 Viney Kumar , Chris T Bauch , Samit Bhattacharyya
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