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We employ a typical genetic circuit model to explore how noise can influence the dynamic structure. With the increase of a key interactive parameter, the model will deterministically go through two bifurcations and three dynamic structure…

Biological Physics · Physics 2026-03-25 Yuxuan Wu , Yuxing Jiao , Yanzhen Zhao , Haojun Jia , Liufang Xu

The human brain is one of the most complex and intriguing scientific topics. The most established theory on neuronal communication is a pure electrical model based on the propagation of intracell cationic charges along the neurons. Here we…

Neurons and Cognition · Quantitative Biology 2024-03-26 Francisco Meseguer , Fernando Ramiro-Manzano

Interspike intervals describe the output of neurons. Signal transmission in a neuronal network implies that the output of some neurons becomes the input of others. The output should reproduce the main features of the input to avoid a…

Probability · Mathematics 2022-09-29 Petr Lansky , Federico Polito , Laura Sacerdote

The steady-state firing rate and firing-rate response of the leaky and exponential integrate-and-fire models receiving synaptic shot noise with excitatory and inhibitory reversal potentials is examined. For the particular case where the…

Neurons and Cognition · Quantitative Biology 2024-03-13 Magnus J E Richardson

Neurons and networks in the cerebral cortex must operate reliably despite multiple sources of noise. To evaluate the impact of both input and output noise, we determine the robustness of single-neuron stimulus selective responses, as well…

Neurons and Cognition · Quantitative Biology 2018-01-24 Ran Rubin , L. F. Abbott , Haim Sompolinsky

Noise, through its interaction with the nonlinearity of the living systems, can give rise to counter-intuitive phenomena such as stochastic resonance, noise-delayed extinction, temporal oscillations, and spatial patterns. In this paper we…

Populations and Evolution · Quantitative Biology 2007-05-23 B. Spagnolo , D. Valenti , A. Fiasconaro

We present a novel mathematical approach to model noise in dynamical systems. We do so by considering dynamics of a chain of diffusively coupled Nagumo cells affected by noise. We show that the noise in transmembrane current can be…

Dynamical Systems · Mathematics 2011-05-13 A. A. Samoletov , B. N. Vasiev

Local networks of neurons are nonlinear systems driven by synaptic currents elicited by its own spiking activity and the input received from other brain areas. Synaptic currents are well approximated by correlated Gaussian noise. Besides,…

Neurons and Cognition · Quantitative Biology 2024-04-09 Gianni Valerio Vinci , Maurizio Mattia

Neurons in the intact brain receive a continuous and irregular synaptic bombardment from excitatory and inhibitory pre-synaptic neurons, which determines the firing activity of the stimulated neuron. In order to investigate the influence of…

Neurons and Cognition · Quantitative Biology 2017-05-23 Simona Olmi , David Angulo-Garcia , Alberto Imparato , Alessandro Torcini

We consider noise-assisted spike propagation in myelinated axons within a multi-compartment stochastic Hodgkin-Huxley model. The noise originates from a finite number of ion channels in each node of Ranvier. For the subthreshold internodal…

Neurons and Cognition · Quantitative Biology 2009-11-13 Anna Ochab-Marcinek , Gerhard Schmid , Igor Goychuk , Peter Hänggi

One of the most important challenges in mathematical neuroscience is to properly illustrate the stochastic nature of neurons. Among different approaches, the noisy leaky integrate-and-fire and the escape rate models are probably the most…

Analysis of PDEs · Mathematics 2017-02-07 Grégory Dumont , Jacques Henry , Carmen Oana Tarniceriu

Bursting oscillations are commonly seen as a mechanism for information coding in neuroscience and have also been observed in many physical, biochemical, and chemical systems. This study focuses on the computational investigation of…

Dynamical Systems · Mathematics 2021-10-15 Na Yu , Xuan Xia , Juan Liyau

Here we study a noise induced transition when the system is driven by a noise source taken as colored and non-Gaussian. We show--using both, a theoretical approximation and numerical simulations-- that there is a shift of the transition as…

Statistical Mechanics · Physics 2009-11-10 Horacio S. Wio , Raul Toral

In a generic neuron model, we present the linear response theory for the firing rate in response to both time dependent input currents and noise amplitudes. In both cases the signal transmission is strongly attenuated for frequencies above…

Biological Physics · Physics 2007-05-23 Bjoern Naundorf , Theo Geisel , Fred Wolf

Neural-network models of high-level brain functions such as memory recall and reasoning often rely on the presence of stochasticity. The majority of these models assumes that each neuron in the functional network is equipped with its own…

Neurons and Cognition · Quantitative Biology 2022-05-17 Jakob Jordan , Mihai A. Petrovici , Oliver Breitwieser , Johannes Schemmel , Karlheinz Meier , Markus Diesmann , Tom Tetzlaff

Noise induced excitability is studied in type I and II Morris-Lecar neurons subject to constant sub threshold input, where fluctuations arise from sodium and potassium ion channels. Ion channels open and close randomly, creating current…

Cell Behavior · Quantitative Biology 2014-09-08 Jay Newby

NF-{\kappa}B, one of key regulators of inflammation, apoptosis, and differentiation, was found to have noisy oscillatory shuttling between the nucleus and the cytoplasm in single cells when cells are stimulated by cytokine TNF{\alpha}. We…

Molecular Networks · Quantitative Biology 2010-10-11 Jaewook Joo

In this paper, we examine the effects of correlated Gaussian noise on a two-dimensional neuronal network that is locally modeled by the Rulkov map. More precisely, we study the effects of the noise correlation on the variations of the mean…

Disordered Systems and Neural Networks · Physics 2010-09-23 Xiaojuan Sun , Matjaz Perc , Qishao Lu , Jürgen Kurths

It has been proposed that neural noise in the cortex arises from chaotic dynamics in the balanced state: in this model of cortical dynamics, the excitatory and inhibitory inputs to each neuron approximately cancel, and activity is driven by…

Disordered Systems and Neural Networks · Physics 2017-04-28 Nimrod Shaham , Yoram Burak

An increasing body of evidence suggests that the trial-to-trial variability of spiking activity in the brain is not mere noise, but rather the reflection of a sampling-based encoding scheme for probabilistic computing. Since the precise…

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