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Context. While synthesis of organic molecules in molecular clouds or protoplanetary disks is complex, observations of interstellar grains, analyses of carbonaceous chondrites, and UV photochemistry experiments are rapidly developing and…

Earth and Planetary Astrophysics · Physics 2022-06-22 Hitoshi Takehara , Daigo Shoji , Shigeru Ida

The rapid evolution and global impact of coronaviruses, notably SARS-CoV-1 and SARS-CoV-2, underscore the importance of understanding their molecular mechanisms in detail. This study focuses on the receptor-binding motif (RBM) within the…

Biological Physics · Physics 2026-03-16 Rafael B. Frigori

In light of the continuing emergence of new SARS-CoV-2 variants and vaccines, we create a simulation framework for exploring possible infection trajectories under various scenarios. The situations of primary interest involve the interaction…

Populations and Evolution · Quantitative Biology 2022-01-10 Kory D. Johnson , Annemarie Grass , Daniel Toneian , Mathias Beiglböck , Jitka Polechová

Covid-19 infection, which spread to the whole world in December 2019 and is still active, caused more than 250 thousand deaths in the world today. Researches on this subject have been focused on analyzing the genetic structure of the virus,…

Machine Learning · Computer Science 2023-04-25 Selcuk Yazar

SARS-CoV-2 is a severe respiratory infection that infects humans. Its outburst entitled it as a pandemic emergence. To get a grip on this, outbreak specific preventive and therapeutic interventions are urgently needed. It must be said that,…

Quantitative Methods · Quantitative Biology 2020-05-07 Giulia Russo , Marzio Pennisi , Marco Viceconti , Francesco Pappalardo

The novel coronavirus SARS-CoV-2 has resulted in a global pandemic with worldwide 6-digital infection rates and thousands death tolls daily. Enormeous effords are undertaken to achieve high coverage of immunization in order to reach herd…

Cell Behavior · Quantitative Biology 2021-09-02 Ralf Kircheis

Vaccines are among the most powerful tools used to combat the COVID-19 pandemic. They are highly effective against infection and substantially reduce the risk of severe disease, hospitalization, ICU admission, and death. However, their…

Quantitative Methods · Quantitative Biology 2022-04-07 Marc Wiedermann , Annika H. Rose , Benjamin F. Maier , Jakob J. Kolb , David Hinrichs , Dirk Brockmann

Purpose: This work advances a Monte Carlo (MC) method to combine ionizing radiation physics with optical physics, in a manner which was implicitly designed for deployment with the most widely accessible parallelization and portability…

Medical Physics · Physics 2020-05-05 Ethan P. M. LaRochelle , Pedro Arce , Brian W. Pogue

At the KATRIN experiment, the electron antineutrino mass is inferred from the shape of the $\beta$-decay spectrum of tritium. Important systematic effects in the Windowless Gaseous Tritium Source (WGTS) of the experiment include the energy…

Instrumentation and Methods for Astrophysics · Physics 2022-10-05 Jonas Kellerer , Felix Spanier

Monte Carlo simulations with the CRISP code were conducted to study spallation and fission fragment distributions induced by intermediate- and high-energy protons and photons on actinide and pre-actinide nuclei. The model accounts for…

General Physics · Physics 2025-09-12 Sun Wenming

Soft X-ray emission from neutron stars affords powerful diagnostic tools for uncovering their surface and interior properties, as well as their geometric configurations. In the atmospheres of neutron stars, the presence of magnetic fields…

High Energy Astrophysical Phenomena · Physics 2025-10-29 Hoa Dinh Thi , Matthew G. Baring , Kun Hu , Alice K. Harding , Joseph A. Barchas

We examine a pair of graph generative models for the therapeutic design of novel drug candidates targeting SARS-CoV-2 viral proteins. Due to a sense of urgency, we chose well-validated models with unique strengths: an autoencoder that…

Biomolecules · Quantitative Biology 2021-05-24 Jenna Bilbrey , Logan Ward , Sutanay Choudhury , Neeraj Kumar , Ganesh Sivaraman

Generation of circularly-polarized (CP) and linearly-polarized (LP) $\gamma$-rays via the single-shot interaction of an ultraintense laser pulse with a spin-polarized counterpropagating ultrarelativistic electron beam has been investigated…

We highlight changes to cell signalling under virus invasion (SARS-CoV-2), involving disturbance of membranes and of nanodomains, modulated by the cytoskeleton. Virus alters the mechanical properties of the membranes, impairing mesophase…

Soft Condensed Matter · Physics 2021-07-16 Christiane Binot , Jean-Francois Sadoc , Claude-Henri Chouard

For radiation protection and environmental impact assessment purpose, the radioactivity induced by carbon ion of Heavy Ion Medical Machine (HIMM) was studied. Radionuclides in accelerator component, cooling water and air at target area…

Instrumentation and Detectors · Physics 2013-12-31 Xu Jun-Kui , Su You-Wu , Li Wu-Yuan , Mao Wang , Xia Jia-Wen , Chen Xi-Meng , Yan Wei-Wei , Xu Chong

The coronavirus disease (COVID-19) pandemic, caused by the coronavirus SARS-CoV-2, has caused 60 millions of infections and 1.38 millions of fatalities. Genomic analysis of SARS-CoV-2 can provide insights on drug design and vaccine…

Other Quantitative Biology · Quantitative Biology 2020-11-26 Changchuan Yin , Stephen S. -T. Yau

The integration of machine learning methods into bioinformatics provides particular benefits in identifying how therapeutics effective in one context might have utility in an unknown clinical context or against a novel pathology. We aim to…

Machine Learning · Computer Science 2020-06-29 Semih Cantürk , Aman Singh , Patrick St-Amant , Jason Behrmann

Particle-in-cell/Monte Carlo technique is used to simulate low pressure electro-negative and electro-positive plasmas at a frequency of 10 MHz. The potential, electric field, electron and ion density, and currents flowing across the plasma…

Plasma Physics · Physics 2007-05-23 M. Ardehali

The accurate prediction of B-cell epitopes is critical for guiding vaccine development against infectious diseases, including SARS and COVID-19. This study explores the use of a deep neural network (DNN) model to predict B-cell epitopes for…

Machine Learning · Computer Science 2024-12-03 Xinyu Shi , Yixin Tao , Shih-Chi Lin

The 200-MeV electron linac of the National Synchrotron Radiation Laboratory (NSRL) located in Hefei is one of the earliest high-energy electron linear accelerators in China. The electrons are accelerated to 200 MeV by five acceleration…

Accelerator Physics · Physics 2014-09-08 Lijuan He , Yuxiong Li , Weimin Li , Zhi Chen , Yukai Chen , Guangyi Ren