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Recent developments in high throughput profiling of individual neurons have spurred data driven exploration of the idea that there exist natural groupings of neurons referred to as cell types. The promise of this idea is that the immense…

Neurons and Cognition · Quantitative Biology 2019-11-14 Rohan Gala , Nathan Gouwens , Zizhen Yao , Agata Budzillo , Osnat Penn , Bosiljka Tasic , Gabe Murphy , Hongkui Zeng , Uygar Sümbül

Semisupervised learning is a learning standard which deals with the study of how computers and natural systems such as human beings acquire knowledge in the presence of both labeled and unlabeled data. Semisupervised learning based methods…

Machine Learning · Computer Science 2014-02-20 V. Jothi Prakash , Dr. L. M. Nithya

Single-cell RNA-seq foundation models achieve strong performance on downstream tasks but remain black boxes, limiting their utility for biological discovery. Recent work has shown that sparse dictionary learning can extract concepts from…

Genomics · Quantitative Biology 2025-10-31 Charlotte Claye , Pierre Marschall , Wassila Ouerdane , Céline Hudelot , Julien Duquesne

Semi-Supervised Learning (SSL) has been proved to be an effective way to leverage both labeled and unlabeled data at the same time. Recent semi-supervised approaches focus on deep neural networks and have achieved promising results on…

Computer Vision and Pattern Recognition · Computer Science 2018-12-14 Hong-Yu Zhou , Avital Oliver , Jianxin Wu , Yefeng Zheng

With ongoing developments and innovations in single-cell RNA sequencing methods, advancements in sequencing performance could empower significant discoveries as well as new emerging possibilities to address biological and medical…

Applications · Statistics 2019-12-19 Jiawei Long , Yu Xia

We present a weakly supervised deep learning method to perform instance segmentation of cells present in microscopy images. Annotation of biomedical images in the lab can be scarce, incomplete, and inaccurate. This is of concern when…

Computer Vision and Pattern Recognition · Computer Science 2019-08-28 Fidel A. Guerrero-Peña , Pedro D. Marrero Fernandez , Tsang Ing Ren , Alexandre Cunha

Despite the success of Graph Neural Networks (GNNs) on various applications, GNNs encounter significant performance degradation when the amount of supervision signals, i.e., number of labeled nodes, is limited, which is expected as GNNs are…

Machine Learning · Computer Science 2022-04-29 Junseok Lee , Yunhak Oh , Yeonjun In , Namkyeong Lee , Dongmin Hyun , Chanyoung Park

One of the major challenges arising from single-cell transcriptomics experiments is the question of how to annotate the associated single-cell transcriptomic profiles. Because of the large size and the high dimensionality of the data,…

Genomics · Quantitative Biology 2024-09-11 Malek Senoussi , Thierry Artières , Paul Villoutreix

Image recognition techniques heavily rely on abundant labeled data, particularly in medical contexts. Addressing the challenges associated with obtaining labeled data has led to the prominence of self-supervised learning and semi-supervised…

Computer Vision and Pattern Recognition · Computer Science 2024-04-17 Hao Feng , Yuanzhe Jia , Ruijia Xu , Mukesh Prasad , Ali Anaissi , Ali Braytee

Although bulk transcriptomic analyses have significantly contributed to an enhanced comprehension of multifaceted diseases, their exploration capacity is impeded by the heterogeneous compositions of biological samples. Indeed, by averaging…

Quantitative Methods · Quantitative Biology 2023-10-24 Bastien Chassagnol , Grégory Nuel , Etienne Becht

Training a neural network with a large labeled dataset is still a dominant paradigm in computational histopathology. However, obtaining such exhaustive manual annotations is often expensive, laborious, and prone to inter and Intra-observer…

Computer Vision and Pattern Recognition · Computer Science 2021-11-03 Chetan L. Srinidhi , Seung Wook Kim , Fu-Der Chen , Anne L. Martel

Cell clustering is crucial for uncovering cellular heterogeneity in single-cell RNA sequencing (scRNA-seq) data by identifying cell types and marker genes. Despite its importance, benchmarks for scRNA-seq clustering methods remain…

Genomics · Quantitative Biology 2025-12-03 Ping Xu , Zaitian Wang , Zhirui Wang , Pengjiang Li , Jiajia Wang , Ran Zhang , Pengfei Wang , Yuanchun Zhou

Effective convolutional neural networks are trained on large sets of labeled data. However, creating large labeled datasets is a very costly and time-consuming task. Semi-supervised learning uses unlabeled data to train a model with higher…

Computer Vision and Pattern Recognition · Computer Science 2016-06-16 Mehdi Sajjadi , Mehran Javanmardi , Tolga Tasdizen

Single-cell multi-omics (scMulti-omics) refers to the paired multimodal data, such as Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq), where the regulation of each cell was measured from different modalities, i.e.…

Machine Learning · Computer Science 2024-10-18 Dian Meng , Bohao Xing , Xinlei Huang , Yanran Liu , Yijun Zhou , Yongjun xiao , Zitong Yu , Xubin Zheng

Learning sentence embeddings often requires a large amount of labeled data. However, for most tasks and domains, labeled data is seldom available and creating it is expensive. In this work, we present a new state-of-the-art unsupervised…

Computation and Language · Computer Science 2021-09-13 Kexin Wang , Nils Reimers , Iryna Gurevych

Single-cell RNA sequencing (scRNA-seq) has revolutionized biological discovery, providing an unbiased picture of cellular heterogeneity in tissues. While scRNA-seq has been used extensively to provide insight into both healthy systems and…

Genomics · Quantitative Biology 2020-03-16 Neal G. Ravindra , Arijit Sehanobish , Jenna L. Pappalardo , David A. Hafler , David van Dijk

In semi-supervised learning for classification, it is assumed that every ground truth class of data is present in the small labelled dataset. Many real-world sparsely-labelled datasets are plausibly not of this type. It could easily be the…

Machine Learning · Statistics 2021-01-11 Matthew Willetts , Stephen J Roberts , Christopher C Holmes

In this paper, we present a novel cross-consistency based semi-supervised approach for semantic segmentation. Consistency training has proven to be a powerful semi-supervised learning framework for leveraging unlabeled data under the…

Computer Vision and Pattern Recognition · Computer Science 2020-06-11 Yassine Ouali , Céline Hudelot , Myriam Tami

Deep learning has achieved unprecedented success in various object detection tasks with huge amounts of labeled data. However, obtaining large-scale annotations for medical images is extremely challenging due to the high demand of labour…

Image and Video Processing · Electrical Eng. & Systems 2022-03-21 Zhizhong Chai , Luyang Luo , Huangjing Lin , Hao Chen , Anjia Han , Pheng-Ann Heng

Recent advances in semi-supervised learning have shown tremendous potential in overcoming a major barrier to the success of modern machine learning algorithms: access to vast amounts of human-labeled training data. Previous algorithms based…

Machine Learning · Computer Science 2019-11-22 Phi Vu Tran