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Single-cell RNA sequencing (scRNA-seq) technology has profiled hundreds of millions of human cells across organs, diseases, development and perturbations to date. However, the high-dimensional sparsity, batch effect noise, category…

Machine Learning · Computer Science 2025-03-07 Zhen Yu , Jianan Han , Yang Liu , Qingchao Chen

Many approaches to transform classification problems from non-linear to linear by feature transformation have been recently presented in the literature. These notably include sparse coding methods and deep neural networks. However, many of…

Machine Learning · Computer Science 2015-07-08 Alessandro Montalto , Giovanni Tessitore , Roberto Prevete

In many modern machine learning applications, the outcome is expensive or time-consuming to collect while the predictor information is easy to obtain. Semi-supervised learning (SSL) aims at utilizing large amounts of `unlabeled' data along…

Methodology · Statistics 2017-11-16 Jessica Gronsbell , Tianxi Cai

Single-cell RNA-seq data are challenging because of the sparseness of the read counts, the tiny expression of many relevant genes, and the variability in the efficiency of RNA extraction for different cells. We consider a simple…

Methodology · Statistics 2020-02-10 Silvia Giulia Galfre' , Francesco Morandin

Single-cell RNA sequencing provides tremendous insights to understand biological systems. However, the noise from dropout can corrupt the downstream biological analysis. Hence, it is desirable to impute the dropouts accurately. In this…

Quantitative Methods · Quantitative Biology 2020-08-11 Kexin Huang

In this paper, we present a deep neural network (DNN) training approach called the "DeepMimic" training method. Enormous amounts of data are available nowadays for training usage. Yet, only a tiny portion of these data is manually labeled,…

Machine Learning · Computer Science 2019-12-03 Itay Mosafi , Eli David , Nathan S. Netanyahu

Semi-supervised multi-organ medical image segmentation aids physicians in improving disease diagnosis and treatment planning and reduces the time and effort required for organ annotation.Existing state-of-the-art methods train the labeled…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Haochen Zhao , Hui Meng , Deqian Yang , Xiaozheng Xie , Xiaoze Wu , Qingfeng Li , Jianwei Niu

The popular methods for semi-supervised semantic segmentation mostly adopt a unitary network model using convolutional neural networks (CNNs) and enforce consistency of the model's predictions over perturbations applied to the inputs or…

Computer Vision and Pattern Recognition · Computer Science 2023-12-19 Xu Zheng , Yunhao Luo , Chong Fu , Kangcheng Liu , Lin Wang

Semi-Supervised Learning (SSL) is a framework that utilizes both labeled and unlabeled data to enhance model performance. Conventional SSL methods operate under the assumption that labeled and unlabeled data share the same label space.…

Computer Vision and Pattern Recognition · Computer Science 2023-11-16 Noam Fluss , Guy Hacohen , Daphna Weinshall

Semi-supervised learning (SSL) aims to train a machine learning model using both labelled and unlabelled data. While the unlabelled data have been used in various ways to improve the prediction accuracy, the reason why unlabelled data could…

Machine Learning · Statistics 2025-10-28 Archer Moore , Heejung Shim , Jingge Zhu , Mingming Gong

Recent studies have shown that the benefits provided by self-supervised pre-training and self-training (pseudo-labeling) are complementary. Semi-supervised fine-tuning strategies under the pre-training framework, however, remain…

Sound · Computer Science 2022-06-28 Bowen Zhang , Songjun Cao , Xiaoming Zhang , Yike Zhang , Long Ma , Takahiro Shinozaki

We have gained access to vast amounts of multi-omics data thanks to Next Generation Sequencing. However, it is challenging to analyse this data due to its high dimensionality and much of it not being annotated. Lack of annotated data is a…

Machine Learning · Computer Science 2022-10-04 Sayed Hashim , Karthik Nandakumar , Mohammad Yaqub

Classes, as fundamental elements of Computer Vision, have been extensively studied within incremental learning frameworks. In contrast, tokens, which play essential roles in many research fields, exhibit similar characteristics of growth,…

Machine Learning · Computer Science 2025-11-19 Jiaxin Qi , Yan Cui , Jianqiang Huang , Gaogang Xie

Long non-coding RNAs (lncRNAs) are important regulators to modulate gene expression and cell proliferation in the developing human brain. Previous methods mainly use bulk lncRNA and mRNA expression data to study lncRNA regulation. However,…

Molecular Networks · Quantitative Biology 2022-12-01 Meng Huang , Jiangtao Ma , Changzhou Long , Junpeng Zhang , Xiucai Ye , Tetsuya Sakurai

Prediction of survival for cancer patients is an open area of research. However, many of these studies focus on datasets with a large number of patients. We present a novel method that is specifically designed to address the challenge of…

Machine Learning · Computer Science 2015-09-30 Hamid Reza Hassanzadeh , John H. Phan , May D. Wang

Deep learning based image segmentation has achieved the state-of-the-art performance in many medical applications such as lesion quantification, organ detection, etc. However, most of the methods rely on supervised learning, which require a…

Computer Vision and Pattern Recognition · Computer Science 2020-04-20 Ruizhe Li , Dorothee Auer , Christian Wagner , Xin Chen

Semi-supervised 3D medical image segmentation aims to achieve accurate segmentation using few labelled data and numerous unlabelled data. The main challenge in the design of semi-supervised learning methods consists in the effective use of…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Yanyan Wang , Kechen Song , Yuyuan Liu , Shuai Ma , Yunhui Yan , Gustavo Carneiro

In this paper, we propose a semi-supervised deep learning method for detecting the specific types of reads that impede the de novo genome assembly process. Instead of dealing directly with sequenced reads, we analyze their coverage graphs…

Machine Learning · Computer Science 2019-04-24 Tomislav Šebrek , Jan Tomljanović , Josip Krapac , Mile Šikić

Single-cell RNA sequencing technologies have revolutionized our understanding of cellular heterogeneity, yet computational methods often struggle to balance performance with biological interpretability. Embedded topic models have been…

Machine Learning · Computer Science 2025-12-08 Hegang Chen , Yuyin Lu , Yifan Zhao , Zhiming Dai , Fu Lee Wang , Qing Li , Yanghui Rao , Yue Li

This paper studies semi-supervised graph classification, a crucial task with a wide range of applications in social network analysis and bioinformatics. Recent works typically adopt graph neural networks to learn graph-level representations…

Machine Learning · Computer Science 2023-04-25 Wei Ju , Xiao Luo , Meng Qu , Yifan Wang , Chong Chen , Minghua Deng , Xian-Sheng Hua , Ming Zhang