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Single-cell RNA sequencing (scRNA-seq) is widely used to reveal heterogeneity in cells, which has given us insights into cell-cell communication, cell differentiation, and differential gene expression. However, analyzing scRNA-seq data is a…

Machine Learning · Computer Science 2023-06-27 Yuta Hozumi , Gu-Wei Wei

Self-supervised learning (SSL) is a machine learning approach where the data itself provides supervision, eliminating the need for external labels. The model is forced to learn about the data structure or context by solving a pretext task.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-19 Markus Marks , Manuel Knott , Neehar Kondapaneni , Elijah Cole , Thijs Defraeye , Fernando Perez-Cruz , Pietro Perona

This paper studies semi-supervised learning of semantic segmentation, which assumes that only a small portion of training images are labeled and the others remain unlabeled. The unlabeled images are usually assigned pseudo labels to be used…

Computer Vision and Pattern Recognition · Computer Science 2022-06-02 Donghyeon Kwon , Suha Kwak

Single-cell RNA-Sequencing (scRNA-Seq) is a revolutionary technique for discovering and describing cell types in heterogeneous tissues, yet its measurement of expression often suffers from large systematic bias. A major source of this bias…

Quantitative Methods · Quantitative Biology 2016-05-17 Martin Barron , Jun Li

Recently, graph-based semi-supervised learning and pseudo-labeling have gained attention due to their effectiveness in reducing the need for extensive data annotations. Pseudo-labeling uses predictions from unlabeled data to improve model…

Computer Vision and Pattern Recognition · Computer Science 2025-10-30 Jingjun Bi , Fadi Dornaika

Semi-supervised learning is a challenging problem which aims to construct a model by learning from a limited number of labeled examples. Numerous methods have been proposed to tackle this problem, with most focusing on utilizing the…

Computer Vision and Pattern Recognition · Computer Science 2021-07-02 Peng Tu , Yawen Huang , Rongrong Ji , Feng Zheng , Ling Shao

The cell cycle is one of the most fundamental biological processes important for understanding normal physiology and various pathologies such as cancer. Single cell RNA sequencing technologies give an opportunity to analyse the cell cycle…

Quantitative Methods · Quantitative Biology 2022-08-11 Alexander Chervov , Andrei Zinovyev

Gene Regulatory Network (GRN) inference is essential for understanding complex cellular mechanisms, rendered tractable through single-cell transcriptomic data. With the emergence of single-cell Foundation Models (scFMs), enhanced…

Machine Learning · Computer Science 2026-05-12 Jiaxin Qi , Hang Li , Yan Cui , Yuhua Zheng , Jianqiang Huang

We propose a weakly-supervised cell tracking method that can train a convolutional neural network (CNN) by using only the annotation of "cell detection" (i.e., the coordinates of cell positions) without association information, in which…

Computer Vision and Pattern Recognition · Computer Science 2020-07-17 Hiroki Tokunaga , Brian Kenji Iwana , Yuki Teramoto , Akihiko Yoshizawa , Ryoma Bise

Deep neural networks currently deliver promising results for microscopy image cell segmentation, but they require large-scale labelled databases, which is a costly and time-consuming process. In this work, we relax the labelling requirement…

Computer Vision and Pattern Recognition · Computer Science 2022-08-04 Youssef Dawoud , Katharina Ernst , Gustavo Carneiro , Vasileios Belagiannis

In this paper, we propose another version of help-training approach by employing a Probabilistic Neural Network (PNN) that improves the performance of the main discriminative classifier in the semi-supervised strategy. We introduce the…

Machine Learning · Computer Science 2015-09-07 Hamidreza Farhidzadeh

Consistency learning plays a crucial role in semi-supervised medical image segmentation as it enables the effective utilization of limited annotated data while leveraging the abundance of unannotated data. The effectiveness and efficiency…

Computer Vision and Pattern Recognition · Computer Science 2023-05-26 Zhenxi Zhang , Ran Ran , Chunna Tian , Heng Zhou , Xin Li , Fan Yang , Zhicheng Jiao

Single-cell RNA sequencing (scRNA-seq) is powerful technology that allows researchers to understand gene expression patterns at the single-cell level. However, analysing scRNA-seq data is challenging due to issues and biases in data…

Genomics · Quantitative Biology 2023-12-14 Jinlu Liu , Sara Wade , Natalia Bochkina

Identification and quantification of condition-specific transcripts using RNA-Seq is vital in transcriptomics research. While initial efforts using mathematical or statistical modeling of read counts or per-base exonic signal have been…

Quantitative Methods · Quantitative Biology 2013-02-26 Tin Chi Nguyen , Nan Deng , Dongxiao Zhu

In this paper we present a new approach to solve semi-supervised classification tasks for biomedical applications, involving a supervised autoencoder network. We create a network architecture that encodes labels into the latent space of an…

Machine Learning · Computer Science 2022-08-24 Cyprien Gille , Frederic Guyard , Michel Barlaud

Semi-supervised learning (SSL) uses unlabeled data during training to learn better models. Previous studies on SSL for medical image segmentation focused mostly on improving model generalization to unseen data. In some applications,…

While neural networks for learning representation of multi-view data have been previously proposed as one of the state-of-the-art multi-view dimension reduction techniques, how to make the representation discriminative with only a small…

Machine Learning · Computer Science 2018-11-13 Vahid Noroozi , Sara Bahaadini , Lei Zheng , Sihong Xie , Weixiang Shao , Philip S. Yu

Training deep neural networks requires massive amounts of training data, but for many tasks only limited labeled data is available. This makes weak supervision attractive, using weak or noisy signals like the output of heuristic methods or…

Machine Learning · Computer Science 2017-12-08 Mostafa Dehghani , Aliaksei Severyn , Sascha Rothe , Jaap Kamps

One paradigm for learning from few labeled examples while making best use of a large amount of unlabeled data is unsupervised pretraining followed by supervised fine-tuning. Although this paradigm uses unlabeled data in a task-agnostic way,…

Machine Learning · Computer Science 2020-10-27 Ting Chen , Simon Kornblith , Kevin Swersky , Mohammad Norouzi , Geoffrey Hinton

Until recently, transcriptomics was limited to bulk RNA sequencing, obscuring the underlying expression patterns of individual cells in favor of a global average. Thanks to technological advances, we can now profile gene expression across…

Quantitative Methods · Quantitative Biology 2018-11-30 Miriam Shiffman , William T. Stephenson , Geoffrey Schiebinger , Jonathan Huggins , Trevor Campbell , Aviv Regev , Tamara Broderick