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Sample pooling consists in combining samples from multiple individuals into a single pool that is then tested using a unique test-kit. A positive test means that at least one individual within the pool is infected. Here, we propose an…

Quantitative Methods · Quantitative Biology 2021-03-18 Vincent Brault , Bastien Mallein , Jean-Francois Rupprecht

CoVID-19 is currently one of the biggest threats to mankind. To date, it is the reason for infections of over 35 lakhs and the death of over 2 lakh human beings. We propose a procedure to detect CoVID-19 affected localities using a sewage…

Other Quantitative Biology · Quantitative Biology 2020-05-18 Ritam Guha , Anik Sengupta , Ankan Dutta

In comparison with individual testing, group testing (also known as pooled testing) is more efficient in reducing the number of tests and potentially leading to tremendous cost reduction. As indicated in the recent article posted on the US…

Populations and Evolution · Quantitative Biology 2021-06-16 Yi-Jheng Lin , Che-Hao Yu , Tzu-Hsuan Liu , Cheng-Shang Chang , Wen-Tsuen Chen

When testing for infections, the standard method is to test each subject individually. If testing methodology is such that samples from multiple subjects can be efficiently combined and tested at once, yielding a positive results if any one…

Methodology · Statistics 2020-04-01 Anže Slosar

Estimating the prevalence of a disease is necessary for evaluating and mitigating risks of its transmission within or between populations. Estimates that consider how prevalence changes with time provide more information about these risks…

Applications · Statistics 2021-11-12 Braden Scherting , Alison Peel , Raina Plowright , Andrew Hoegh

We consider a novel method to increase the reliability of COVID-19 virus or antibody tests by using specially designed pooled testings. Instead of testing nasal swab or blood samples from individual persons, we propose to test mixtures of…

Quantitative Methods · Quantitative Biology 2020-07-30 Jirong Yi , Myung Cho , Xiaodong Wu , Weiyu Xu , Raghu Mudumbai

Despite of the fast development of highly effective vaccines to control the current COVID$-$19 pandemic, the unequal distribution and availability of these vaccines worldwide and the number of people infected in the world lead to the…

Detection of defective members of large populations has been widely studied in the statistics community under the name "group testing", a problem which dates back to World War II when it was suggested for syphilis screening. There the main…

Information Theory · Computer Science 2009-09-28 Mahdi Cheraghchi , Ali Hormati , Amin Karbasi , Martin Vetterli

With the huge spike in the COVID-19 cases across the globe and reverse transcriptase-polymerase chain reaction (RT-PCR) test remains a key component for rapid and accurate detection of severe acute respiratory syndrome coronavirus 2…

Machine Learning · Computer Science 2021-10-20 Satvik Tripathi

Testing for infection with SARS-CoV-2 is an important intervention in reducing onwards transmission of COVID-19, particularly when combined with the isolation and contact-tracing of positive cases. Many countries with the capacity to do so…

Populations and Evolution · Quantitative Biology 2022-07-19 Miguel E. P. Silva , Martyn Fyles , Li Pi , Jasmina Panovska-Griffiths , Caroline Jay , Thomas House , Elizabeth Fearon

Group testing allows saving chemical reagents, analysis time, and costs, by testing pools of samples instead of individual samples. We introduce a class of group testing protocols with small dilution, suited to operate even at high…

Physics and Society · Physics 2022-03-09 Marco Chiani , Gianluigi Liva , Enrico Paolini

Detection of rare variants by resequencing is important for the identification of individuals carrying disease variants. Rapid sequencing by new technologies enables low-cost resequencing of target regions, although it is still prohibitive…

Genomics · Quantitative Biology 2009-09-03 Noam Shental , Amnon Amir , Or Zuk

During the SARS-CoV-2 pandemic, polymerase chain reaction (PCR) and lateral flow device (LFD) tests were frequently deployed to detect the presence of SARS-CoV-2. Many of these tests were singleplex, and only tested for the presence of a…

Applications · Statistics 2024-09-02 Martyn Fyles , Christopher E. Overton , Tom Ward , Emma Bennett , Tom Fowler , Ian Hall

Summary: Polymerase chain reaction-based assays are the current gold standard for detecting and diagnosing SARS-CoV-2. However, as SARS-CoV-2 mutates, we need to constantly assess whether existing PCR-based assays will continue to detect…

The motivation for this paper comes from the ongoing SARS-CoV-2 Pandemic. Its goal is to present a previously neglected approach to non-adaptive group testing and describes it in terms of residuated pairs on partially ordered sets. Our…

Other Statistics · Statistics 2022-02-15 Marcus Greferath , Cornelia Roessing

We propose two-stage adaptive pooling schemes, 2-STAP and 2-STAMP, for detecting COVID-19 using real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) test kits. Similar to the Tapestry scheme of Ghosh et al., the…

Information Theory · Computer Science 2020-07-07 Anoosheh Heidarzadeh , Krishna R. Narayanan

An important component of every country's COVID-19 response is fast and efficient testing - to identify and isolate cases, as well as for early detection of local hotspots. For many countries, producing a sufficient number of tests has been…

Methodology · Statistics 2020-10-27 J. Batson , N. Bottman , Y. Cooper , F. Janda

Rapid antigen tests detect proteins at the surface of virus particles, identifying the disease during its infectious phase. In contrast, PCR tests detect viral genomes; they can thus diagnose COVID-19 before the infectious phase but also…

Populations and Evolution · Quantitative Biology 2022-01-21 Jitka Polechová , Kory D. Johnson , Pavel Payne , Alex Crozier , Mathias Beiglböck , Pavel Plevka , Eva Schernhammer

Repeat asymptomatic testing in order to identify and quarantine infectious individuals has become a widely-used intervention to control SARS-CoV-2 transmission. In some workplaces, and in particular health and social care settings with…

Populations and Evolution · Quantitative Biology 2022-10-18 Carl A Whitfield , University of Manchester COVID-19 Modelling Group , Ian Hall

When testing for a disease such as COVID-19, the standard method is individual testing: we take a sample from each individual and test these samples separately. An alternative is pooled testing (or "group testing"), where samples are mixed…

Applications · Statistics 2021-12-14 Matthew Aldridge , David Ellis