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In online multiple testing, an a priori unknown number of hypotheses are tested sequentially, i.e. at each time point a test decision for the current hypothesis has to be made using only the data available so far. Although many powerful…

Methodology · Statistics 2025-03-11 Vincent Jankovic , Lasse Fischer , Werner Brannath

We consider a susceptible, infected, removed (SIR) system where the transmission rate may be temporarily reduced for a fixed amount of time. We show that in order to minimize the total number of fatalities, the transmission rate should be…

Dynamical Systems · Mathematics 2021-07-20 Yuanyuan Feng , Gautam Iyer , Lei Li

Testing is a crucial control mechanism for an epidemic outbreak because it enables the health authority to detect and isolate the infected cases, thereby limiting the disease transmission to susceptible people, when no effective treatment…

This document aims to estimate and describe the effects of the social distancing measures implemented in several countries with the expectancy of controlling the spread of COVID-19. The procedure relies on the classic…

Populations and Evolution · Quantitative Biology 2021-06-28 Gerardo L. Febres

This paper is concerned with SIR (susceptible $\to$ infected $\to$ removed) household epidemic models in which the infection response may be either mild or severe, with the type of response also affecting the infectiousness of an…

Probability · Mathematics 2010-05-26 Frank Ball , Tom Britton , David Sirl

We study the effectiveness of tracking and testing in mitigating or suppressing epidemic outbreaks, in combination with or as an alternative to quarantines and global lockdowns. We study these intervention methods on a network-based SEIR…

Populations and Evolution · Quantitative Biology 2020-07-15 Yoav Kolumbus , Noam Nisan

We study the impact of parameter estimation and state measurement errors on a control framework for optimally mitigating the spread of epidemics. We capture the epidemic spreading process using a susceptible-infected-removed (SIR) epidemic…

Systems and Control · Electrical Eng. & Systems 2024-08-08 Baike She , Lei Xin , Shreyas Sundaram , Philip E. Paré

Suppressing SARS-CoV-2 will likely require the rapid identification and isolation of infected individuals, on an ongoing basis. RT-PCR (reverse transcription polymerase chain reaction) tests are accurate but costly, making regular testing…

In this study, we propose a time-dependent Susceptible-Exposed-Infected-Recovered (SEIR) model for the analysis of the SARS-CoV-2 epidemic outbreak in three different countries, the United States of America, Italy and Iceland using public…

Populations and Evolution · Quantitative Biology 2021-11-08 P. Girardi , C. Gaetan

In this work we analyze mathematically the consequences and effectiveness of strategies to control an epidemic in the framework of classical SEIR models with multiple parallel infectious stages. We define the mathematical concept of a…

Dynamical Systems · Mathematics 2023-08-17 Annibal Figueiredo , Tarcısio Marciano da Rocha Filho

The Susceptible-Infected-Recovered (SIR) model has successfully mimicked the propagation of such airborne diseases as influenza A (H1N1). Although the SIR model has recently been studied in a multilayer networks configuration, in almost all…

Physics and Society · Physics 2015-07-16 L. G. Alvarez Zuzek , H. E. Stanley , L. A. Braunstein

During the SARS-CoV-2 pandemic, polymerase chain reaction (PCR) and lateral flow device (LFD) tests were frequently deployed to detect the presence of SARS-CoV-2. Many of these tests were singleplex, and only tested for the presence of a…

Applications · Statistics 2024-09-02 Martyn Fyles , Christopher E. Overton , Tom Ward , Emma Bennett , Tom Fowler , Ian Hall

According to the current perception, symptomatic, presymptomatic, and asymptomatic infectious persons can infect the healthy population susceptible to the SARS-Cov-2. More importantly, various reports indicate that the number of…

Populations and Evolution · Quantitative Biology 2020-11-24 Saptarshi Chatterjee , Apurba Sarkar , Mintu Karmakar , Swarnajit Chatterjee , Raja Paul

The existence of immune or cured individuals in a population and whether there is sufficient followup in a sample of censored observations on their lifetimes to be confident of their presence are questions of major importance in medical…

Statistics Theory · Mathematics 2022-06-22 Ross Maller , Sidney Resnick , Soudabeh Shemehsavar

Until a vaccine or therapy is found against the SARS-CoV-2 coronavirus, reaching herd immunity appears to be the only mid-term option. However, if the number of infected individuals decreases and eventually fades only beyond this threshold,…

Optimization and Control · Mathematics 2020-06-11 Pierre-Alexandre Bliman , Michel Duprez , Yannick Privat , Nicolas Vauchelet

The COVID-19 pandemic has been a great catastrophe that upended human lives and caused millions of deaths all over the world. The rapid spread of the virus, with its early-stage exponential growth and subsequent 'waves', caught many medical…

Populations and Evolution · Quantitative Biology 2022-05-31 Anne V. Ginzburg , Valeriy V. Ginzburg , Julia O. Ginzburg , Ana Garcia Arias , Leela Rakesh

We measure the effect of different public health regulations to the spread of COVID-19, based on a SEIRA model -- a SEIR model including asymptomatic transmissions. The cumulative confirmed cases and death show nonlinear positive…

Populations and Evolution · Quantitative Biology 2020-04-15 Weijie Pang

We propose two SIR models which incorporate sociological behavior of groups of individuals. It is these differences in behaviors which impose different infection rates on the individual susceptible populations, rather than biological…

Dynamical Systems · Mathematics 2022-07-26 Robert F. Allen , Katherine Heller , Matthew A. Pons

The rapidly spreading Covid-19 that affected almost all countries, was first reported at the end of 2019. As a consequence of its highly infectious nature, countries all over the world have imposed extremely strict measures to control its…

Populations and Evolution · Quantitative Biology 2020-07-13 Semra Ahmetolan , Ayse Humeyra Bilge , Ali Demirci , Ayse Peker-Dobie , Onder Ergonul

The importance of a strict quarantine has been widely debated during the COVID-19 epidemic even from the purely epidemiological point of view. One argument against strict lockdown measures is that once the strict quarantine is lifted, the…

Physics and Society · Physics 2021-02-03 Varun Nimmagadda , Oleg Kogan , Evgeniy Khain