Related papers: Tau affects P53 function and cell fate during the …
Background: The locus of the gene PTK2B encoding the tyrosine kinase Pyk2 has been associated with the risk of late-onset Alzheimer's disease, the predominant form of dementia. Pyk2 is primarily expressed in neurons where it is involved in…
The combined analysis of $\nu_\mu$ disappearance and $\nu_e$ appearance data of NO$\nu$A experiment leads to three nearly degenerate solutions. This degeneracy can be understood in terms of deviations in $\nu_e$ appearance signal, caused by…
The oxidative damage of DNA is a compelling issue in molecular biophysics as it plays a vital role in the epigenetic control of gene expression and is believed to be associated with mutagenesis, carcinogenesis, and ageing. To understand the…
Although there are various types of cancer treatments, none of these currently take into account the effect of ageing of the immune system and hence altered responses to cancer. Recent studies have shown that in vitro stimulation of T cells…
Beta decay is one of the key factors to understand the r process and evolution of massive stars. The Gamow Teller (GT) transitions drive the beta decay process. We employ the proton neutron quasiparticle random phase approximation (on QRPA)…
Amyloid beta peptides (A\b{eta}), implicated in Alzheimers disease (AD), interact with the cellular membrane and induce amyloid toxicity. The composition of cellular membranes changes in aging and AD. We designed multi component lipid…
We explore the effects of overdispersed DNA lesion distribution on the shapes of cell surviving curves of mammalian cells exposed to hadrons at various doses. To provide a theoretical framework in resolving discrepancies between…
Genetic alterations initiate tumors and enable the evolution of drug resistance. The pro-cancer view of mutations is however incomplete, and several studies show that mutational load can reduce tumor fitness. Given its negative effect,…
Neurodegenerative diseases are characterized as the progressive loss of neural cells, e.g. neurons, glial cells. Ageing, monogenic variations, viral infections, and many other factors are determined and speculated as causes for them. While…
Background:Gene regulations often change over time rather than being constant. But many of gene regulatory networks extracted from databases are static. The tumor suppressor gene $P53$ is involved in the pathogenesis of many tumors, and its…
The three kinds of parameter degeneracy in neutrino oscillation, the intrinsic, sign and octant degeneracy, form an eight-fold degeneracy. The nature of this eight-fold degeneracy can be visualized on the ($\sin^22\theta_{13}$,…
The theoretical study of deformability of special sequence of DNA double helix TATA-box is presentated. The paper elaborates on the mechanisms of abnormal deformation of DNA TATA-box double helix that cannot be explained using the standard…
This paper presents a numerical study of the dynamics of DNA double helix breakage under the influence of external forces using the Peyrard-Bishop-Dauxois (PBD) model. The PBD model represents DNA as a chain of nonlinearly coupled…
Degeneracy of the genetic code is a biological way to minimize effects of the undesirable mutation changes. Degeneration has a natural description on the 5-adic space of 64 codons $\mathcal{C}_5 (64) = \{n_0 + n_1 5 + n_2 5^2 : n_i = 1, 2,…
Alzheimer's disease (AD), as a progressive brain disease, affects cognition, memory, and behavior. Similarly, limbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently defined common neurodegenerative disease that mimics the…
The spreading of misfolded proteins is a known hallmark in some neurodegenerative diseases, known as proteinopathies. A significant example is the tau protein, associated with many pathologies, such as Alzheimer's. In this work, we discuss…
The QCD corrections to the moments of the invariant mass distribution in the semileptonic $\tau$ decays are considered. The effect of the renormalization scheme dependence on the fitted values of alpha_s(m^2_tau) and the condensates is…
We review the radiative corrections to the $\tau \to P (P) \nu_\tau [\gamma]$ decays and their implications for several SM tests: lepton universality, CKM unitarity and non-standard interactions.
An improved formalism of the two-neutrino double-beta decay ($2\nu\beta\beta$-decay) rate is presented, which takes into account the dependence of energy denominators on lepton energies via the Taylor expansion. Till now, only the leading…
Molecular biology explains function of molecules by their geometrical and electronical structures that are mainly determined by utilization of quantum effects in chemistry. However, further quantum effects are not thought to play any…