Related papers: Tau affects P53 function and cell fate during the …
How much information does a cell inherit from its ancestors beyond its genetic sequence? What are the epigenetic mechanisms that allow this? Despite the rise in available epigenetic data, how such information is inherited through the cell…
DNA shape readout is an important mechanism of target site recognition by transcription factors, in addition to the sequence readout. Several models of transcription factor-DNA binding which consider DNA shape have been developed in recent…
We propose a methodology for the identification of transcription factors involved in the deregulation of genes in tumoral cells. This strategy is based on the inference of a reference gene regulatory network that connects transcription…
We discuss a direct test of the relation of time and energy in the very long-lived decay of tritium (H3) (meanlife \tau ~ 18 yrs) with the width \Gamma ~ 10^{-24} eV [set by the time-energy uncertainty (TEU)], using the newfound possibility…
Some recent $\tau$-physics results are presented from the BaBar and Belle experiments at the SLAC and KEK B factories, which produce copious numbers of $\tau$-lepton pairs. Measurements of the tau mass and lifetime allow to test lepton…
Over the last years, huge resources of biological and medical data have become available for research. This data offers great chances for machine learning applications in health care, e.g. for precision medicine, but is also challenging to…
We study the role of cations on the stability of double stranded DNA (dsDNA) molecules.It is known that the two strands of double stranded DNA(dsDNA) have negative charge due to phosphate group. Cations in the form of salt in the solution,…
Understanding battery degradation in electric vehicles (EVs) under real-world conditions remains a critical yet under-explored area of research. Central to this investigation is the challenge of estimating the specific degradation modes in…
Since the $\nu_\tau(\bar\nu_\tau) A_Z \to \tau^\mp X$ reaction is notoriously difficult to be directly measured, the information on the dynamics of this nuclear process should be extracted from the analysis of the energy and angular…
The evolution of the determination of the strong coupling constant $\alpha_s$ from the leptonic branching ratios, the lifetime, and the invariant mass distributions of the hadronic final state of the $\tau$ lepton over the last two decades…
We derive precise standard model predictions for the dilepton invariant mass and the tau energy distributions in inclusive B -> Xc tau nu decay. We include Lambda_QCD^2/m_b^2 and alpha_s corrections using the 1S short-distance mass scheme,…
Aging remains a fundamental open problem in modern biology. Although there exist a number of theories on aging on the cellular scale, nearly nothing is known about how microscopic failures cascade to macroscopic failures of tissues, organs…
Evolving genomes increase a number of their genes by gene duplications. To escape degradation in a functionless pseudogene, any gene duplicate needs to be guarded by negative (purifying) selection from otherwise inevitable fixation of…
We propose that the evolutionary purpose of junk DNA is to protect the gene. Mutation agents, such as retro-viruses, hit ``decoy'' DNA most of the time. Although the argument is far from general, we propose that the percentage of junk DNA…
Energy and angular distributions of the tau decay products in the CERN-to-Gran Sasso $\nu_\tau$ appearance experiments are studied for the decay modes $\tau\to\pi\nu$ and $\tau\to l\bar\nu\nu$ (l=e or mu). We find that the decay particle…
Tumor recurrence, driven by the evolution of drug resistance is a major barrier to therapeutic success in cancer. Resistance is often caused by genetic alterations such as point mutation, which refers to the modification of a single genomic…
We calculated the differential cross sections of the processes in which one of the pair created tau particles at an e^+ e^- collider decays into lepton flavor violating final states e.g. tau -> mu gamma, tau -> 3 mu, tau -> mu ee. Using the…
Alzheimer's disease (AD) is a common form of dementia observed in the elderly due to neurodegenerative disorder and dysfunction. This arises from alterations in synaptic functioning of neurons leading to cognitive impairment and memory…
The double-helical structure of DNA results from canonical base pairing and stacking interactions. However, variations from steady-state conformations result from mechanical perturbations in cells. These different topologies have…
Proteins and nucleic acids form non-Newtonian liquids with complex rheological properties that contribute to their function in vivo. Here we investigate the rheology of the transcription factor NANOG, a key protein in sustaining embryonic…