Related papers: Tau affects P53 function and cell fate during the …
Analytic formulae are given for order alpha_s perturbative QCD corrections to the double differential distribution of the tau lepton energy and the invariant mass of the tau + antineutrino system in semileptonic decays of the bottom quark.…
Throughout the process of aging, deterioration of bone macro- and micro-architecture, as well as material decomposition result in a loss of strength and therefore in an increased likelihood of fractures. To date, precise contributions of…
We present the mechanism of interaction of Wnt network module, which is responsible for periodic sometogenesis, with p53 regulatory network, which is one of the main regulators of various cellular functions, and switching of various…
Three major biomarkers: beta-amyloid (A), pathologic tau (T), and neurodegeneration (N), are recognized as valid proxies for neuropathologic changes of Alzheimer's disease. While there are extensive studies on cerebrospinal fluids…
Mutations in proto-oncogenes (ONGO) and the loss of regulatory function of tumor suppression genes (TSG) are the common underlying mechanism for uncontrolled tumor growth. While cancer is a heterogeneous complex of distinct diseases,…
Here we study how mutations which change physical properties of cell proteins (stability) impact population survival and growth. In our model the genotype is presented as a set of N numbers, folding free energies of cells N proteins.…
Mutations can arise from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that are not repaired correctly. We introduce a model that relates the source of mutations to their accumulation with cell…
In semi-leptonic $B$ decays with a tau lepton, features of the production process are imprinted on the tau helicity states. Since the tau momentum cannot be fully reconstructed experimentally, the available information on the tau properties…
The perturbative QCD corrections to the semileptonic decay width of the tau lepton are evaluated in the next-next-to-leading order from the contour integral representation in various renormalization schemes, using numerical solution of the…
Alzheimer's disease is the most common neurodegenerative disorder. Its pathological development is connected with the misfolding and accumulation of two toxic proteins: amyloid-beta and tau proteins. Mathematical models provide a valuable…
We study the longitudinal, transverse, and normal polarization components of the tau lepton in the decays $\bar{B}^0 \to D^{(\ast)} \tau^- \bar\nu_{\tau}$ and discuss their role in searching for new physics (NP) beyond the standard model…
We study the $\tau^- \to \nu_{\tau} \pi^{-}\pi^{0}\ell^{+}\ell^{-}$ ($\ell=e,\,\mu$) decays, which are $O(\alpha^2)$-suppressed with respect to the dominant di-pion tau decay channel. Both the inner-bremsstrahlung and the structure- (and…
We benefit from a recent lattice determination of the full set of vector, axial and tensor form factors for the $\Lambda_b\to \Lambda^*_c(2595)\tau\bar\nu_\tau$ and $\Lambda^*_c(2625)\tau\bar\nu_\tau$ semileptonic decays to study the…
Systemic properties of living cells are the result of molecular dynamics governed by so-called genetic regulatory networks (GRN). These networks capture all possible features of cells and are responsible for the immense levels of adaptation…
We propose a method that uses a two-species ordinary differential equation (ODE) model to characterize misfolded tau (or simply tau) protein spreading in Alzheimer's disease (AD) and calibrates it from clinical data. The unknown model…
Theoretical reasoning suggests that human cancer may result from knocking down the genetic constraints evolved for maintenance of the metazoan multicellularity, which, however, requires a critical test. Using xenograft-based experimental…
Protein aggregates in the brain play a central role in cognitive decline and structural damage associated with neurodegenerative diseases. For instance, in Alzheimer's disease the formation of Amyloid-beta plaques and tau proteins…
Metallic nanoparticles are more and more widely used in an increasing number of applications. Consequently, they are more and more present in the environment, and the risk that they may represent for human health must be evaluated. This…
We analyze the sensitivity of hadronic tau decays to non-standard interactions within the model-independent framework of the Standard Model Effective Field Theory (SMEFT). Both exclusive and inclusive decays are studied, using the latest…
Understanding non-genetic determinants of cell fate is critical for developing and improving cancer therapies, as genetically identical cells can exhibit divergent outcomes under the same treatment conditions. In this work, we present a…