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Laser Doppler holography (LDH) is a full-field imaging technique that was recently used in the human eye to reveal blood flow contrasts in the retinal and choroidal vasculature non-invasively, and with high temporal resolution. We here…

Medical Physics · Physics 2020-04-01 L. Puyo , M. Paques , M. Fink , J-A Sahel , M. Atlan

Laser Doppler holography (LDH) is a full-field blood flow imaging technique able to reveal human retinal and choroidal blood flow with high temporal resolution. We here report on using LDH in the anterior segment of the eye without making…

Laser Doppler holography (LDH) is an interferometric blood flow imaging technique based on full-field measurements of the Doppler spectrum. LDH has so far been demonstrated in the retina with ultrafast cameras, typically at 75 kHz. We show…

Image and Video Processing · Electrical Eng. & Systems 2020-08-26 Leo Puyo , Michel Paques , Michael Atlan

Full-field swept-source optical coherence tomography (FF-SS-OCT) and laser Doppler holography (LDH) are two holographic imaging techniques presenting unique capabilities for ophthalmology. We report on interlaced FF-SS-OCT and LDH imaging…

Medical Physics · Physics 2022-03-01 Léo Puyo , Hendrik Spahr , Clara Pfäffle , Gereon Hüttmann , Dierck Hillmann

Laser Doppler holography was introduced as a full-field imaging technique to measure blood flow in the retina and choroid with an as yet unrivaled temporal resolution. We here investigate separating the different contributions to the power…

Medical Physics · Physics 2021-06-02 Léo Puyo , Michel Paques , Mathias Fink , José-Alain Sahel , Michael Atlan

We report on local superficial blood flow monitoring in biological tissue from laser Doppler holographic imaging. In time averaging recording conditions, holography acts as a narrowband bandpass filter, which, combined with a frequency…

Doppler holography is an emerging retinal imaging technique that captures the dynamic behavior of blood flow with high temporal resolution, enabling quantitative assessment of retinal hemodynamics. This requires accurate segmentation of…

Computer Vision and Pattern Recognition · Computer Science 2026-02-20 Marius Dubosc , Yann Fischer , Zacharie Auray , Nicolas Boutry , Edwin Carlinet , Michael Atlan , Thierry Geraud

A comprehensive assessment of retinal health demands reliable and precise methods to measure localized blood perfusion. Despite considerable advancements in imaging techniques, such as indocyanine green and fluorescein angiography, along…

Medical Physics · Physics 2024-03-15 Michael Atlan

Laser Doppler holography is a planar blood flow imaging technique recently introduced in ophthalmology to image human retinal and choroidal blood flow non-invasively. Here we present a digital method based on the Doppler spectrum asymmetry…

Medical Physics · Physics 2021-08-10 Léo Puyo , Michel Paques , Michael Atlan

This study presents a novel quantitative estimation method for total retinal arterial blood flow utilizing real-time Doppler holography at an unprecedented frame rate of 33,000 frames per second. This technique, leveraging high-speed…

Image and Video Processing · Electrical Eng. & Systems 2024-09-27 Yann Fischer , Zacharie Auray , Olivier Martinache , Marius Dubosc , Noé Topéza , Chloé Magnier , Maxime Boy-Arnould , Michael Atlan

High-speed digital holography reveals local blood flow contrasts in the eye fundus through deterministic signal analysis, leveraging a forward scattering model of dynamically diffused light. This approach enables the estimation of absolute…

Instrumentation and Detectors · Physics 2025-05-14 Zacharie Auray , Yann Fischer , Olivier Martinache , Michael Atlan

Effective clutter filtering is crucial in suppressing tissue clutter and extracting blood flow signal in Doppler ultrasound. Recent advances in eigen-based clutter filtering techniques have enabled ultrasound imaging of microvasculature…

Medical Physics · Physics 2024-05-21 Chengwu Huang , U-Wai Lok , Jingke Zhang , Hui Liu , Shigao Chen

Photoacoustic (PA) imaging is an emerging hybrid imaging modality that combines rich optical spectroscopic contrast and high ultrasonic resolution and thus holds tremendous promise for a wide range of pre-clinical and clinical applications.…

Image and Video Processing · Electrical Eng. & Systems 2023-03-22 Mengjie Shi , Tom Vercauteren , Wenfeng Xia

We report a pilot study with a wide-field laser Doppler detection scheme used to perform laser Doppler anemometry and imaging of particle seeded microflow. The optical field carrying the local scatterers (particles) dynamic state, as a…

Optics · Physics 2013-12-24 Michel Gross , Michael Atlan , Jacques Leng

This paper addresses the problem of high-resolution Doppler blood flow estimation from an ultrafast sequence of ultrasound images. Formulating the separation of clutter and blood components as an inverse problem has been shown in the…

Image and Video Processing · Electrical Eng. & Systems 2020-07-13 Duong-Hung Pham , Adrian Basarab , Ilyess Zemmoura , Jean-Pierre Remenieras , Denis Kouame

The eye offers a unique opportunity for non-invasive exploration of cardiovascular diseases. Optical angiography in the retina requires sensitive measurements, which hinders conventional full-field laser Doppler imaging schemes. To overcome…

Medical Physics · Physics 2018-09-18 L. Puyo , M. Paques , M. Fink , J. -A. Sahel , M. Atlan

We performed non-invasive video imaging of retinal blood flow in a pigmented rat by holographic interferometry of near-infrared laser light backscattered by retinal tissue, beating against an off-axis reference beam sampled at a frame rate…

Instrumentation and Detectors · Physics 2016-07-27 Mathilde Pellizzari , Manuel Simonutti , Julie Degardin , Jose-Alain Sahel , Mathias Fink , Michel Paques , Michael Atlan

We report a demonstration of laser Doppler holography at a sustained acquisition rate of 250 Hz on a 1 Megapixel complementary metal-oxide-semiconductor (CMOS) sensor array and image display at 10 Hz frame rate. The holograms are optically…

Optics · Physics 2015-06-12 Benjamin Samson , Michael Atlan

A single-pixel digital holography system with phase-encoded illumination using a digital micromirror device (DMD) as a spatial light modulator (SLM) is presented. The enhanced switching rate of DMDs, far exceeding the stringent frame-rate…

The choroid is a highly vascularized tissues supplying the retinal pigment epithelium and photoreceptors. Its implication in retinal diseases is gaining increasing interest. However, investigating the anatomy and flow of the choroid remains…

Medical Physics · Physics 2021-06-02 Léo Puyo , Michel Paques , Mathias Fink , José-Alain Sahel , Michael Atlan
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