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This study presents a proof-of-concept for a novel Bayesian inverse method in a one-dimensional setting, aimed at proton beam therapy treatment verification. Our methodology is predicated on a hypothetical scenario wherein strategically…

Applications · Statistics 2023-11-21 Alexander M. G. Cox , Laura Hattam , Andreas E. Kyprianou , Tristan Pryer

We are exploring low-dose proton radiography and computed tomography (pCT) as techniques to improve the accuracy of proton treatment planning and to provide artifact-free images for verification and adaptive therapy at the time of…

Proton imaging has become a key diagnostic for measuring electromagnetic fields in high-energy-density (HED) laboratory plasmas. Compared to other techniques for diagnosing fields, proton imaging is a non-perturbative measurement that can…

The two dominant radiotherapy methods are either simplified in terms of beam generation and handling, which compromises the energy deposition curve in tissues (photon therapy), or require extensive accelerator facilities and complex beam…

Accelerator Physics · Physics 2023-09-12 Marta Monikowska , Marcin Patecki

Stereotactic body radiation therapy (SBRT) and hypofractionation using pencil-beam scanning (PBS) proton therapy (PBSPT) is an attractive option for thoracic malignancies. Combining the advantages of target coverage conformity and critical…

Boron Neutron Capture Therapy (BNCT) is a neutron radiotherapy used to treat tumours cells previously doping with Boron-10. This therapy requires an epithermal neutron beam for the treatment of deep tumours and a thermal beam for shallow…

Instrumentation and Detectors · Physics 2021-06-02 M. Macías , B. Fernández , J. Praena

The question of whether or not neutron therapy works has been answered. It is a qualified yes, as is the case with all of radiation therapy. But, neutron therapy has not kept pace with the rest of radiation therapy in terms of beam delivery…

Medical Physics · Physics 2014-09-09 Thomas K. Kroc , James S. Welsh

Particle therapy is a growing cancer treatment modality worldwide. However, there still remains a number of unanswered questions considering differences in the biological response between particles and photons. These questions, and probing…

Purpose: To improve target coverage and reduce the dose in the surrounding organs-at-risks (OARs), we developed an image-guided treatment method based on a precomputed library of treatment plans controlled and delivered in real-time.…

Medical Physics · Physics 2022-11-02 Valentin Hamaide , Kevin Souris , Damien Dasnoy , Francois Glineur , Benoit Macq

Background: Intensity-modulated proton therapy (IMPT) using pencil beam technique scans tumor in a layer by layer, then spot by spot manner. It can provide highly conformal dose to tumor targets and spare nearby organs-at-risk (OAR). Fast…

Medical Physics · Physics 2024-11-28 Aoxiang Wang , Ya-Nan Zhu , Jufri Setianegara , Yuting Lin , Peng Xiao , Qingguo Xie , Hao Gao

Compact, stable, and versatile laser-driven ion sources hold great promise for applications ranging from medicine to materials science and fundamental physics. While single-shot sources have demonstrated favorable beam properties, including…

Experimental studies of microdosimetry in therapeutic ion beams have been performed using several detectors. The differences among them lie on the shapes, the site sizes, and the material. Coin-shaped solid-state detectors made of silicon…

Instrumentation and Detectors · Physics 2020-05-11 Giulio Magrin

Verification of patient specific proton stopping powers obtained in the patient treatment position can be used to reduce the distal margins needed in particle beam planning. Proton radiography can be used as a pre-treatment instrument to…

Proton radiography is a new scatheless diagnostic tool, and which provides a potential development direction for advanced hydrotesting. Recently a low energy proton radiography system has been developed at CAEP. This system has been…

Accelerator Physics · Physics 2013-10-22 Tao Wei , Guojun Yang , Jidong Long , Xiaozhong He , Yiding Li , Xiaoding Zhang , Chaofan Ma , Liangchao Zhao , Jinshui Shi

Hadron therapy, because of the dosimetric and radiobiological advantages, is more and more often used in tumour treatment. This treatment method leads also to the radioactive effects induced by energetic protons on nuclei. Nuclear reactions…

Medical Physics · Physics 2018-04-26 Przemysław Sękowski , Izabela Skwira-Chalot , Tomasz Matulewicz

Laser-driven ion acceleration is an attractive technique for compact high-energy ion sources. Currently, among various physical and technical issues to be solved, the boost of ion energy and the reduction of energy spread represent the key…

Plasma Physics · Physics 2022-07-19 Xing-Long Zhu , Wei-Yuan Liu , Min Chen , Su-Ming Weng , Paul McKenna , Zheng-Ming Sheng , Jie Zhang

A proton irradiation site for silicon detectors has been developed and commissioned at the Bonn Isochronous Cyclotron. The accelerator provides 14 MeV proton beams of up to 1 $\mu$A at beam widths of a few mm to the setup. Devices Under…

Instrumentation and Detectors · Physics 2024-05-07 Pascal Wolf , Dennis Sauerland , Reinhard Beck , Jochen Dingfelder

Beams of radioactive heavy ions allow researchers to study rare and unstable atomic nuclei, shedding light into the internal structure of exotic nuclei and on how chemical elements are formed in stars. However, the extraction and transport…

Accelerator Physics · Physics 2025-06-25 Sergio Lopez-Caceres , Daniel Santiago-Gonzalez

The plasma panel sensor is an ionizing photon and particle radiation detector derived from PDP technology with high gain and nanosecond response. Experimental results in detecting cosmic ray muons and beta particles from radioactive sources…

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