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The diffusion of active microscopic organisms in complex environments plays an important role in a wide range of biological phenomena from cell colony growth to single organism transport. Here, we investigate theoretically and…

Fluid Dynamics · Physics 2018-01-16 Juan L. Aragones , Shahrzad Yazdi , Alfredo Alexander-Katz

Stochastic process models for spatiotemporal data underlying random fields find substantial utility in a range of scientific disciplines. Subsequent to predictive inference on the values of the random field (or spatial surface indexed…

Methodology · Statistics 2024-07-26 Aritra Halder , Didong Li , Sudipto Banerjee

We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable. We derive analytical criteria for the appearance of…

Quantitative Methods · Quantitative Biology 2009-02-19 Pierre-Emmanuel Morant , Quentin Thommen , François Lemaire , Constant Vandermoëre , Benjamin Parent , Marc Lefranc

Training a diffusion model approximates a map from a data distribution $\rho$ to the optimal score function $s_t$ for that distribution. Can we differentiate this map? If we could, then we could predict how the score, and ultimately the…

Machine Learning · Computer Science 2025-09-30 Christopher Scarvelis , Justin Solomon

Diffusion models are a popular class of generative models trained to reverse a noising process starting from a target data distribution. Training a diffusion model consists of learning how to denoise noisy samples at different noise levels.…

Machine Learning · Computer Science 2025-10-07 Ameya Daigavane , YuQing Xie , Bodhi P. Vani , Saeed Saremi , Joseph Kleinhenz , Tess Smidt

In this work, to improve the spin readout efficiency of the nitrogen vacancy (NV) center, a real-time Bayesian estimation algorithm is proposed, which combines both the prior probability distribution and the fluorescence likelihood function…

Given a connected region in two-dimensional space where events of a certain kind occur according to a certain time-varying density, we consider the problem of setting up a network of autonomous mobile agents to detect the occurrence of…

Multiagent Systems · Computer Science 2016-07-05 Rodrigo R. Esch , Fábio Protti , Valmir C. Barbosa

Recent work has established a path-gradient estimator for simple variational Gaussian distributions and has argued that the path-gradient is particularly beneficial in the regime in which the variational distribution approaches the exact…

Machine Learning · Computer Science 2022-06-22 Lorenz Vaitl , Kim A. Nicoli , Shinichi Nakajima , Pan Kessel

Stochastic neurons and hard non-linearities can be useful for a number of reasons in deep learning models, but in many cases they pose a challenging problem: how to estimate the gradient of a loss function with respect to the input of such…

Machine Learning · Computer Science 2013-08-16 Yoshua Bengio , Nicholas Léonard , Aaron Courville

Randomized experiments are the gold standard for evaluating the effects of changes to real-world systems. Data in these tests may be difficult to collect and outcomes may have high variance, resulting in potentially large measurement error.…

Machine Learning · Statistics 2018-06-27 Benjamin Letham , Brian Karrer , Guilherme Ottoni , Eytan Bakshy

We introduce a new approach for estimating the invariant density of a multidimensional diffusion when dealing with high-frequency observations blurred by independent noises. We consider the intermediate regime, where observations occur at…

Statistics Theory · Mathematics 2024-04-19 Raphaël Maillet , Grégoire Szymanski

Stochastic reaction-diffusion models can be analytically studied on complex networks using the linear noise approximation. This is illustrated through the use of a specific stochastic model, which displays traveling waves in its…

Statistical Mechanics · Physics 2015-06-16 Malbor Asllani , Tommaso Biancalani , Duccio Fanelli , Alan J. McKane

Current quantum computers suffer from non-stationary noise channels with high error rates, which undermines their reliability and reproducibility. We propose a Bayesian inference-based adaptive algorithm that can learn and mitigate quantum…

Quantum Physics · Physics 2023-08-30 Samudra Dasgupta , Arshag Danageozian , Travis S. Humble

We consider a particle that is subject to a constant force and scatters inelastically on a vibrating periodically corrugated floor. At small friction and small radius of the circular scatterers the dynamics is dominated by resonances…

Chaotic Dynamics · Physics 2009-11-10 R. Klages , I. F. Barna , L. Matyas

Fluorescent and luminescent gene reporters allow us to dynamically quantify changes in molecular species concentration over time on the single cell level. The mathematical modeling of their interaction through multivariate dynamical models…

Quantitative Methods · Quantitative Biology 2009-07-07 Michal Komorowski , Barbel Finkenstadt , Claire V. Harper , David A. Rand

Eukaryotic cells respond to a chemoattractant gradient by forming intracellular gradients of signaling molecules that reflect the extracellular chemical gradient - an ability called directional sensing. Quantitative experiments have…

Cell Behavior · Quantitative Biology 2017-02-08 Keita Kamino , Yohei Kondo

We discuss the distribution of various estimators for extracting the diffusion constant of single Brownian trajectories obtained by fitting the squared displacement of the trajectory. The analysis of the problem can be framed in terms of…

Statistical Mechanics · Physics 2015-05-28 Denis Boyer , David S. Dean

In what has been described as the fourth age of Quantum Chemistry, variational nuclear motion programs are now routinely being used to obtain the vibration-rotation levels and corresponding wavefunctions of small molecules to the sort of…

Chemical Physics · Physics 2016-09-23 Jonathan Tennyson

Computer experiments are becoming increasingly important in scientific investigations. In the presence of uncertainty, analysts employ probabilistic sensitivity methods to identify the key-drivers of change in the quantities of interest.…

Methodology · Statistics 2024-07-02 Isadora Antoniano-Villalobos , Emanuele Borgonovo , Xuefei Lu

In this note, we observe the behavior of gradient flow and discrete and noisy gradient descent in some simple settings. It is commonly noted that addition of noise to gradient descent can affect the trajectory of gradient descent. Here, we…

Optimization and Control · Mathematics 2019-04-19 Y. Cooper
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