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The movement of molecules inside living cells is a fundamental feature of biological processes. The ability to both observe and analyse the details of molecular diffusion in vivo at the single molecule and single cell level can add…

Quantitative Methods · Quantitative Biology 2012-11-21 Alex Robson , Kevin Burrage , Mark Leake

We study the interface dynamics of a binary particle mixture in a rotating cylinder numerically. By considering only the particle motion in axial direction, it is shown that the initial dynamics can be well described by a one-dimensional…

Soft Condensed Matter · Physics 2007-05-23 Christian M. Dury , Gerald H. Ristow

Living organisms survive and multiply even though they have uncertain and incomplete information about their environment and imperfect models to predict the consequences of their actions. Bayesian models have been proposed to face this…

Emerging Technologies · Computer Science 2015-11-13 Jacques Droulez , David Colliaux , Audrey Houillon , Pierre Bessière

Establishing sharp and correctly positioned boundaries in spatial gene expression patterns is a central task, both in developmental and synthetic biology. We consider situations where a global morphogen gradient provides positional…

Biological Physics · Physics 2022-06-09 Mareike Bojer , Stephan Kremser , Ulrich Gerland

Sensor noise sources cause differences in the signal recorded across pixels in a single image and across multiple images. This paper presents a Bayesian approach to decomposing and characterizing the sensor noise sources involved in imaging…

Distributed optimization enables networked agents to cooperatively solve a global optimization problem even with each participating agent only having access to a local partial view of the objective function. Despite making significant…

Optimization and Control · Mathematics 2022-10-04 Yongqiang Wang , Tamer Başar

The position of a reaction front, propagating into a metastable state, fluctuates because of the shot noise of reactions and diffusion. A recent theory [B. Meerson, P.V. Sasorov, and Y. Kaplan, Phys. Rev. E 84, 011147 (2011)] gave a closed…

Statistical Mechanics · Physics 2015-06-04 Evgeniy Khain , Baruch Meerson

We consider refractive index sensing with optical bounds states in the continuum (BICs) in dielectric gratings. Applying a perturbative approach we derived the differential sensitivity and the figure of merit of a sensor operating in the…

Second-order information -- such as curvature or data covariance -- is critical for optimisation, diagnostics, and robustness. However, in many modern settings, only the gradients are observable. We show that the gradients alone can reveal…

Machine Learning · Computer Science 2026-04-08 Arash Jamshidi , Katsiaryna Haitsiukevich , Kai Puolamäki

Bayesian experimental design (BED) is to answer the question that how to choose designs that maximize the information gathering. For implicit models, where the likelihood is intractable but sampling is possible, conventional BED methods…

Machine Learning · Computer Science 2021-03-16 Jiaxin Zhang , Sirui Bi , Guannan Zhang

For optimizing a non-convex function in finite dimension, a method is to add Brownian noise to a gradient descent, allowing for transitions between basins of attractions of different minimizers. To adapt this for optimization over a space…

Probability · Mathematics 2025-05-13 Pierre Germain , Pierre Monmarché

We address the estimation of the loss parameter of a bosonic channel probed by Gaussian signals. We derive the ultimate quantum bound on precision and show that no improvement may be obtained by having access to the environment degrees of…

Quantum Physics · Physics 2009-11-13 Alex Monras , Matteo G. A. Paris

We present a Bayesian nonparametric model for conditional distribution estimation using Bayesian additive regression trees (BART). The generative model we use is based on rejection sampling from a base model. Typical of BART models, our…

Methodology · Statistics 2022-02-02 Yinpu Li , Antonio R. Linero , Jared S. Murray

Living cells are known to generate non-Gaussian active fluctuations significantly larger than thermal fluctuations owing to various active processes. Understanding the effect of these active fluctuations on various physicochemical…

Soft Condensed Matter · Physics 2022-07-26 Govind Paneru , Jin Tae Park , Hyuk Kyu Pak

We develop a comprehensive quantum estimation framework to quantify how precisely gravitationally induced decoherence can be inferred in optomechanical systems, using single-mode Gaussian probe states. Our approach combines a microscopic…

Living cells sense noisy biochemical signals crucial for survival, yet models incorporating intracellular signaling are limited. This study examines how cells sense chemotactic concentrations through phosphorylation readouts in Ca2+…

Subcellular Processes · Quantitative Biology 2025-08-22 Swoyam Srirupa , Pradeep , Vaibhav Wasnik

Quantum sensors hold considerable promise for precision measurement, yet their capabilities are inherently constrained by environmental noise. A fundamental task in quantum sensing is determining the precision limit of noisy sensor devices.…

Quantum Physics · Physics 2026-04-14 Dayou Yang , Moulik Ketkar , Koenraad Audenaert , Susana F. Huelga , Martin B. Plenio

We study the field concentration phenomenon between two closely spaced perfect conductors with imperfect bonding interfaces of low conductivity type. The boundary condition on these interfaces is given by a Robin-type boundary condition. We…

Analysis of PDEs · Mathematics 2024-11-07 Hongjie Dong , Zhuolun Yang , Hanye Zhu

This paper studies distance estimation for diffusive molecular communication. The Cramer-Rao lower bound on the variance of the distance estimation error is derived. The lower bound is derived for a physically unbounded environment with…

Information Theory · Computer Science 2015-11-20 Adam Noel , Karen C. Cheung , Robert Schober

The fundamental biological processes of development of tissues and organs in multicellular organisms is governed by various signaling molecules, which are called morphogens. It is known that spatial and temporal variations in concentration…

Biological Physics · Physics 2015-04-07 Behnaz Bozorgui , Hamid Teimouri , Anatoly B. Kolomeisky